Abstract
Total-body exposure to > 1 Gy of ionizing radiation at dose rates > 1 cGy per minute suppresses hematopoiesis in humans. Severity of bone marrow inhibition, duration of decreased blood cell levels, and likelihood of spontaneous recovery are dose dependent in the range of 1–10 Gy. Although experimental and clinical data suggest that some hematopoietic stem cells survive doses of radiation ≥ 10 Gy, hematopoietic recovery is unlikely at higher doses because of toxicity to non hematopoietic organs or because supportive measures are unable to prolong survival long enough for recovery.1–3
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References
United Nations Scientific Committee on Atomic Radiation. Sources, Effects and Risks of Ionizing Radiation. 1988 Report to the General Assembly with Annexes. United Nations, NY, 1988.
Gale, R. P. Immediate medical consequences of nuclear accidents: Lessons from Chernobyl. JAMA 258: 625–628, 1987.
Barabanova, A. B., Baranov, A. E., Guskova, A. K., et al. Acute Radiation Effects in Man. National Committee on Radiation Protection, Moscow, 1986.
Winston, D. J., Ho, W. G., Gale, R. P., et al. Therapeutic granulocyte transfusions for documented infections: A controlled trial of ninety-five infectious granulocytopenic episodes. Ann Intern Med 97: 509–515, 1982.
Jammet, H., Mathe, G., Pendic, B., et al. Study of six cases of accidental acute total-body irradiation. Rev Fr Etud Clin Bio14: 210–225, 1959.
Gale, R. P., and Reisner, Y. The role of bone marrow transplants after nuclear accidents. Lancet 1: 923–925, 1988.
Baranov, A., Gale, R. P., Guskova, A. K., et al. Bone marrow transplantation after the Chernobyl nuclear accident. N Engl J Med 321: 205–212, 1989.
Dexter, M. Growth factors: From the laboratory to the clinic. Nature 321: 198, 1986.
Nienhuis, A. W. Hematopoietic growth factors. N Engl J Med 318: 916–918, 1988.
Butturini, A., De Souza, P. C., Gale, R. P., et al. Use of recombinant granulocyte-macrophage colony-stimulating factor in the Brazil radiation accident. Lancet 11: 471–475, 1988.
Brandt, S. J., Peters, W. P., Atwater, S. K., et al. Effect of recombinant human granulocyte-macrophage colony-stimulating factor on hematopoietic reconstitution after high dose chemotherapy and bone marrow transplantation. N Engl J Med 318: 869–876, 1988.
Gabrilove, J. L., Jakubowski, A., Scher, H., et al. Effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional-cell carcinoma of the urothelium. N Engl J Med 318: 1414–1422, 1988.
Vadhan-Raj, S., Keating, M., LeMaistre, A., et al. Effects of recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes. N Engl J Med 317: 1545–1552, 1987.
Bronchud, M. H., Scarffe, J. H., Thatcher, N., et al. Phase I/11 study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer. Br J Cancer 56: 809–813, 1987.
Morstyn, G., Campbell, L., Sousa, L. M., et al. Effect of granulocyte colony-stimulating factor on neutropenia induced by cytotoxic chemotherapy. Lancet 1: 667–672, 1988.
Champlin, R. E., Nimer, S. D., Ireland, P., et al. Treatment of refractory aplastic anemia with recombinant granulocyte-macrophage colony-stimulating factor. Blood 73: 694–699, 1989.
Steward, W. P., Scarffe, J. H., Austin, K., et al. Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) given as a daily short infusion: A phase I dose-toxicity study. Br J Cancer 59: 142–145, 1989.
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Butturini, A., Gale, R.P. (1990). Role of Hematopoietic Growth Factors in Radiation Victims. In: Browne, D., Weiss, J.F., MacVittie, T.J., Pillai, M.V. (eds) Treatment of Radiation Injuries. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0864-3_14
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DOI: https://doi.org/10.1007/978-1-4899-0864-3_14
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