Skip to main content

β-casomorphins: Do They Have Physiological Significance?

  • Chapter

Abstract

Milk represents an essential food for the newborn mammal. In addition to nutrients milk contains a variety of important materials, e.g. substances with immunological relevance1 and a considerable number of hormones whose physiological significance is not yet clearly understood.2

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. L.A. Hanson, The mammary gland as an immunological organ, Immunol. Today 3: 168 (1982).

    Article  Google Scholar 

  2. O. Koldovsky, Hormones in milk, Life Sei. 26: 1833 (1980).

    Article  CAS  Google Scholar 

  3. V. Brantl and H. Teschemacher, Opioids in milk, Trends Pharmacol. Sei 4: 193 (1983).

    Google Scholar 

  4. V. Brantl and K. Neubert, Opioid peptides derived from food proteins, Trends Pharmacol. Sci. 7: 6 (1986).

    Article  CAS  Google Scholar 

  5. C. Zioudrou and W.A. Klee, Possible roles of peptides derived from food proteins in brain functions, in: “Nutrition and the Brain”, R.J. Wurtman and J.J. Wurtman, eds., Raven Press, New York (1979).

    Google Scholar 

  6. S. Loukas, D. Varoucha, C. Zioudrou, R.A. Streaty and W.A. Klee, Opioid activities and structures of α-caseinderived exorphins, Biochemistry 22:4567 (1983).

    Article  CAS  Google Scholar 

  7. V. Brantl, H. Teschemacher, A. Henschen and F. Lottspeich, Novel opioid peptides derived from casein (ß-casomorphins): I. Isolation from bovine casein peptone, Hoppe-Seyler’s Z. Physiol. Chem. 360:1211 (1979).

    Article  CAS  Google Scholar 

  8. V. Brantl, Novel opioid peptides derived from human ß-casein: human ß-casomorphins, Eur. J. Pharmacol. 106:213 (1984).

    Article  CAS  Google Scholar 

  9. I.S. Zagon, P.J. McLaughlin, D.J. Weaver and E. Zagon, Opiates, endorphins and the developing organism: A comprehensive bibliography, Neurosci. Biobehav. Rev. 6:439 (1982).

    Article  CAS  Google Scholar 

  10. B. Ribadeau-Dumas, G. Brignon, F. Grosclaude and J.-C. Mercier, Structure primaire de la caseine ß-bovine: Sequence complete, Eur. J. Biochem. 25:505 (1972).

    Article  CAS  Google Scholar 

  11. A. Henschen, F. Lottspeich, V. Brantl and H. Teschemacher, Novel opioid peptides derived from casein (ß-casomorphins). II. Structure of active components from bovine casein peptone, Hoppe-Seyler’s Z. Physiol. Chem. 360:1216 (1979).

    Google Scholar 

  12. F. Lottspeich, A. Henschen, V. Brantl and H. Teschemacher, Novel opioid peptides derived from casein (ß-casomorphins). III. Synthetic peptides corresponding to components from bovine casein peptone, Hoppe-Seyler’s Z. Physiol. Chem. 361:1835 (1980).

    Article  CAS  Google Scholar 

  13. V. Brantl, H. Teschemacher, J. Bläsig, A. Henschen and F. Lottspeich, Opioid activities of ß-casomorphins, Life Sci. 28:1903 (1981).

    Article  CAS  Google Scholar 

  14. K.-J. Chang, P. Cuatrecasas, E.T. Wei and J.-K. Chang, Analgesic activity of intracerebroventicular administration of morphiceptin and ß-casomorphins: Correlation with the morphine (μ) receptor binding affinity, Life Sci, 30:1547 (1982).

    Article  CAS  Google Scholar 

  15. B.C. Richardson and J.C. Mercier, The primary structure of the ovine ß-caseins, Eur. J. Biochem. 99:285 (1979).

    Article  CAS  Google Scholar 

  16. P. Petrilli, F. Addeo and L. Chianese, Primary structure of water buffalo ß-casein: Tryptic and CNBr peptides, Ital. J. Biochem. 32:336 (1983).

    CAS  Google Scholar 

  17. R. Greenberg, M.L. Groves and H.J. Dower, Human ß-casein. Amino acid sequence and identification of phosphorylation sites, J. Biol. Chem. 259:5132 (1984).

    CAS  Google Scholar 

  18. G. Koch, K. Wiedemann and H. Teschemacher, Opioid activities of human ß-casomorphins, Naunyn-Schmiedeberg’s Arch. Pharmacol. 331:351 (1985).

    Article  CAS  Google Scholar 

  19. M. Yoshikawa, T. Yoshimura and H. Chiba, Opioid peptides from human ß-casein, Agric. Biol. Chem. 48:3185 (1984).

    Article  CAS  Google Scholar 

  20. W. Kromer, W. Pretzlaff and R. Woinoff, Regional Distribution of an opioid mechanism in the guinea-pig isolated intestine, J. Pharm. Pharmacol. 33:98 (1981).

    Article  CAS  Google Scholar 

  21. G. Grecksch, C. Schweigert and H. Matthies, Evidence for analgesic activity of ß-casomorphin in rats, Neurosci. Lett. 27:325 (1981).

    Article  CAS  Google Scholar 

  22. K.G. Reymann, A.N. Chepkova, K. Schulzeck and T. Ott, Effects of ß-casomorphin on dentate hippocampal field potentials in freely moving rats, Biomed. Biochim. Acta 44:749 (1985).

    CAS  Google Scholar 

  23. V. Schusdziarra, A. Holland, R. Schick, A. de la Fuente, M. Klier, V. Maier, V. Brantl and E.F. Pfeiffer, Modulation of post-prandial insulin release by ingested opiate-like substances in dogs, Diabetologia 24:113 (1983).

    Article  CAS  Google Scholar 

  24. V. Schusdziarra, R. Schick, A. de la Fuente, A. Holland, V. Brantl and E.F. Pfeiffer, Effect of ß-casomorphins on somatostatin release in dogs, Endocrinologyy 112:1948 (1983).

    Article  CAS  Google Scholar 

  25. V. Schusdziarra, R. Schick, A. Holland, A. de la Fuente, J. Specht, V. Maier, V. Brantl and E.F. Pfeiffer, Effect of opiate-active substances on pancreatic polypeptide levels in dogs, Peptides 4:205 (1983).

    Article  CAS  Google Scholar 

  26. T. Mitsuma, T. Nogimori and M. Chaya, ß-Casomorphin inhibits thyrotropin secretion in rats, Exp. Clin. Endocrinol. 84:324 (1984).

    Article  CAS  Google Scholar 

  27. J. Nedvidkova, E. Kasafirek, A. Dlabac and V. Felt, Effect of beta-casomorphin and its analogue on serum prolactin in the rat, Exp. Clin. Endocrinol. 85:249 (1985).

    Article  CAS  Google Scholar 

  28. J.E. Zadina and A.J. Kastin, Interactions between the antiopiate Tyr-MIF-1 and the Mu opiate morphiceptin at their respective binding sites in brain, Peptides 6:965 (1985).

    Article  CAS  Google Scholar 

  29. F. Parker, D. Migliore-Samour, F. Floch, A. Zerial, G.H. Werner, J. Jolies, M. Casaretto, H. Zahn and P. Jolies, Immunostimulating hexapeptide from human casein: amino acid sequence, synthesis and biological properties, Eur. J. Biochem. 145:677 (1984).

    Article  CAS  Google Scholar 

  30. P. Petrilli, D. Picone, C. Caporale, F. Addeo, S. Auricchio and G. Marino, Does casomorphin have a functional role? FEBS Lett. 169:53 (1984).

    Article  CAS  Google Scholar 

  31. J. Svedberg, J. de Haas, G. Leimenstoll, F. Paul and H. Teschemacher, Demonstration of ß-casomorphin immunoreactive materials in in vitro digests of bovine milk and in small intestine contents after bovine milk ingestion in adult humans, Peptides 6:825 (1985).

    Article  CAS  Google Scholar 

  32. K.-J. Chang, Y.F. Su, D.A. Brent and J.-K. Chang, Isolation of a specific u-opiate receptor peptide, morphiceptin, from an enzymatic digest of milk proteins, J. Biol. Chem. 260:9706 (1985).

    CAS  Google Scholar 

  33. B. Hartrodt, K. Neubert, G. Fischer, U. Demuth, T. Yoshimoto and A. Barth, Degradation of ß-casomorphin-5 by proline-specific endopeptidase (PSE) and post-proline cleaving enzyme (PPCE), Pharmazie 37:72 (1982).

    CAS  Google Scholar 

  34. B. Hartrodt, K. Neubert, G. Fischer, H. Schulz and A. Barth, Synthese und enzymatischer Abbau von ß-Casomorphin-5, Pharmazie 37:165 (1982).

    CAS  Google Scholar 

  35. G. Kreil, M. Umbach, V. Brantl and H. Teschemacher, Studies on the enzymatic degradation of ß-casomorphins, Life Sci. 33, Suppl. 1:137 (1983).

    Article  Google Scholar 

  36. M. Umbach, H. Teschemacher, K. Praetorius, R. Hirschhäuser and H, Bostedt, Demonstration of a ß-casomorphin immurioreactive material in the plasma of newborn calves after milk intake, Reg. Peptides 12:223 (1985).

    Article  CAS  Google Scholar 

  37. G. Koch, K. Wiedemann and W. Zimmermann, Human β-Casomorphin-8 Immunoreactive materials in the plasma of nursing mothers, Naunyn-Schmiedeberg’s Arch. Pharmacol. 332:R 85 (1986).

    Google Scholar 

  38. H. Stark, B. Lössner and H. Matthies, Degradation of ß-casomorphin in the rat brain in vivo, Biomed. Biochim. Acta 45:557 (1986).

    CAS  Google Scholar 

  39. H. Meisel, Chemical characterization and opioid activity of an exorphin isolated from in vivo digests of casein, FEBS Lett. 196:223 (1986).

    Article  CAS  Google Scholar 

  40. J.E. Morley, Food peptides: A new class of hormones? J. Am. Med. Assoc. 247:2379 (1982).

    Article  CAS  Google Scholar 

  41. H. Teschemacher, M. Umbach, U. Hamel, K. Praetorius, G. Ahnert-Hilger, V. Brantl, F. Lottspeich and A. Henschen, No evidence for the presence of ß-casomor-phins in human plasma after ingestion of cows’ milk or milk products, J. Dairy Res. 53:135 (1986).

    Article  CAS  Google Scholar 

  42. J. Panksepp, L. Normanseil, S. Siviy, J. Rossi III and A.J. Zolovick, Casomorphins reduce separation distress in chicks, Peptides 5:829 (1984).

    Article  CAS  Google Scholar 

  43. A. Ermisch, H.-J. Rühle, K. Neubert, B. Hartrodt and R. Landgraf, On the blood-brain barrier to peptides: H ß-casomorphin-5 uptake by eighteen brain regions in vivo, J. Neurochem. 41:1229 (1983).

    Article  CAS  Google Scholar 

  44. G. Püschel, R. Mentlein and E. Heymann, Isolation and characterization of dipeptidyl peptidase IV from human placenta, Eur. J. Biochem. 126:359 (1982).

    Article  Google Scholar 

  45. S.S.C. Yen, M.E. Quigley, R.L. Reid, J.F. Ropert and N.S. Cetel, Neuroendocrinology of opioid peptides and their role in the control of gonadotropin and prolactin secretion, Am. J. Obstet. Gynecol. 152:485 (1985).

    CAS  Google Scholar 

  46. C.A. Leadem and S.P. Kalra, Effects of endogenous opioid peptides and opiates on luteinizing hormone and prolactin secretion in ovariectomized rats, Neuroendocrinology 41:342 (1985).

    Article  CAS  Google Scholar 

  47. D.M. Wright, Evidence for a spinal site at which opioids may act to inhibit the milk-ejection reflex, J. Endocrinol. 106:401 (1985).

    Article  CAS  Google Scholar 

  48. L.H. Lindström, F. Nyberg, L. Terenius, K. Bauer, G. Besev, L.M. Gunne, S. Lyrenäs, G. Willdeck-Lund and B. Lindberg, CSF and plasma ß-casomorphin-like opioid peptides in post-partum psychosis, Am. J. Psychiatry 141:1059 (1984).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer Science+Business Media New York

About this chapter

Cite this chapter

Teschemacher, H. (1987). β-casomorphins: Do They Have Physiological Significance?. In: Goldman, A.S., Atkinson, S.A., Hanson, L.Å. (eds) Human Lactation 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0837-7_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-0837-7_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0839-1

  • Online ISBN: 978-1-4899-0837-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics