Abstract
Milk contains high concentrations of numerous growth factors including epidermal growth factor (EGF)1 and insulin-like growth factor-1 (IGF-1)2,3,4, observations that have led to the suggestion that milk growth factors may play an important role in infant growth and development.1,4 This would be possible only if growth factors survive digestion in the neonatal gastrointestinal tract. Moreover, direct actions on tissues other than the gut mucosa would further require that substantial amounts of milk growth factors are absorbed intact into the neonatal circulation.
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References
L.C. Read, F.M. Upton, G.L. Francis, J.C. Wallace, G.W. Dahlenburg, and F.J. Ballard, Changes in the growth-promoting activity of human milk during lactation, Pediatr. Res. 18: 133 (1984).
G.L. Francis, L.C. Read, F.J. Ballard, C.J. Bagley, F.M. Upton, P.M. Gravestock, and J.C. Wallace, Purification and partial sequence analysis of insulin-like growth factor 1 from bovine colostrum, Biochem. J. 233: 207 (1985).
R.C. Baxter, Z. Zaltsman, and J.R. Turtle, Immunoreactive somatomedin-C/insulin-like growth factor 1 and its binding protein in human milk, J. Clin. Endoc. Metab. 58: 955 (1984).
O. Koldovsky, A. Bedrick, P. Pollack, R.K. Rao, and W. Thornburg, Hormones in milk: their presence and possible physiological significance, in: Effects of Human Milk on the Recipient Infant; International Meeting on Human Lactation held in Konstanz, Germany, to be published by Plenum Press, New York.
W. Thornburg, L. Matrisian, B. Magun, and O. Koldovsky, Gastrointestinal absorption of epidermal growth factor in suckling rats, Amer. J. Physiol. 246: G80 (1984).
J.-F. Beaulieu, and R. Calvert, The effect of epidermal growth factor (EGF) on the differentiation of the rough endoplasmic reticulum in fetal mouse small intestine in organ culture, J. Histochem. Cvtochem. 29: 765 (1981).
H.W. Sundell, M.E. Gray, F.S. Serenius, M.B. Escobedo, and M.T. Stahlman, Effects of epidermal growth factor on lung maturation in fetal lambs, Amer. J. Pathol. 100: 707 (1980).
M.S. Urdea, J.P. Merryweather, G.T. Mullenbach, D. Coit, U. Heberlein, P. Valenzuela, and P.J. Barr, Chemical synthesis of a gene for human epidermal growth factor urogastrone and its expression in yeast, Proc. Natl. Acad. Sci., USA 80: 7461 (1983).
L.C. Read, L. Summer, S.M. Gale, C. George-Nascimento, F.J. Ballard, and J.C. Wallace, Immunological, receptor-binding and biological properties of synthetic-gene reconmbinant human epidermal growth factor: comparison with the natural growth factor from human urine and milk, J. Endoc. 109: 245 (1986).
G.F. Brown, D.G. Armstrong, and J.C. MacRae, The establishment in one operation of a cannula into the rumen and re-entrant cannulae into the duodenum and ileum of the sheep, Brit. Vet. J. 124: 78 (1968).
H.G. Windmueller, and A.E. Spaeth, Vascular perfusion of rat small intestine: metabolic studies with isolated and in situ preparations, Fed. Proc. 36: 177 (1977).
F.W.R. Brambell, The passive immunity of the young animal, Biol. Rev. 33: 120 (1958).
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Read, L.C., Gale, S.M., George-Nascimento, C. (1987). Intestinal Absorption of Epidermal Growth Factor in Newborn Lambs. In: Goldman, A.S., Atkinson, S.A., Hanson, L.Å. (eds) Human Lactation 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0837-7_22
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DOI: https://doi.org/10.1007/978-1-4899-0837-7_22
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