Abstract
Taurine is a widely distributed amino acid which has been associated with a broad range of physiological actions, particularly in excitable tissues. These include, for example, a role in heart function (17), retinal function (24,27,31,32), and neural development (9,38,39). In addition, neurophysiological and biochemical evidence has suggested that taurine acts as an inhibitory neurotransmitter or neuromodulator in the central nervous system (21,26,29,30). In no case, however, has the specific function of taurine been elucidated, and progress towards deciphering its role in these various systems has been considerably retarded by the lack of selective agonists and antagonists. A major factor which has hampered development of such probes has been the absence of a receptor model that is specifically sensitive to taurine.
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Gleeson, R.A., Trapido-Rosenthal, H.G., Carr, W.E.S. (1987). A Taurine Receptor Model: Taurine-Sensitive Olfactory Cells in the Lobster. In: Huxtable, R.J., Franconi, F., Giotti, A. (eds) The Biology of Taurine. Advances in Experimental Medicine and Biology, vol 217. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0405-8_27
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DOI: https://doi.org/10.1007/978-1-4899-0405-8_27
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