Skip to main content

Neurotransmission and Neuromodulation Involved in the Control of Respiration

  • Chapter
  • 123 Accesses

Abstract

In classical textbooks of physiology the network generating respiratory rhythm was described as an “oscillator”, and it used to be modelled “cybernetically” by analogy to electronic oscillators. Such an interpretation resulted from the then-actual concept of synaptic transmission as a mere continuation of nerve conduction.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Agnati, L. F., Fuxe, K., Zoli, M., Merlo Pich, E., Benfenati, F., Zini, I., and Goldstein, M., 1986, Aspects of the information handling by the central nervous system: focus on cotransmission in the aged rat brain, Progr. Brain Res. 68: 291.

    Article  CAS  Google Scholar 

  • Akil, H. S., Watson, S. J., Young, E., Lewis, M.E., Khachaturian, H. and Walker, J. M., 1984, Endogenous opioids: biology and function, Ann. Rev. Neurosci. 7: 223.

    Article  PubMed  CAS  Google Scholar 

  • Aoki, M., Mori, S., Kawahara, K., Watanabe, H., and Ebata. N., 1980, Generation of spontaneous respiratory rhythm in spinal cats, Brain Res. 202: 51.

    PubMed  CAS  Google Scholar 

  • Berridge, M. J., 1984, Inositol triphosphate and diacylglycerol as second messengers, Biochem. J. 220: 345.

    PubMed  CAS  Google Scholar 

  • Borison, H. L., 1981, Central nervous respiratory depressants — anesthetics, hypnotics, sedatives and other respiratory depressants, in: “Respiratory Pharmacology”, J. G. Widdicombe, ed., Pergamon Press, Oxford.

    Google Scholar 

  • Brown, D. A., 1986, Synaptic mechanisms, Trends Neurosci. 9: 468.

    Article  CAS  Google Scholar 

  • BudziAska, K., Grieb, P., and Romaniuk, J.R., 1985, Morphine selectively facilitates the inspiratory-inhibitory reflex in rabbits, Experientia 41: 458.

    Article  Google Scholar 

  • Champagnat, J., Richter, D. W., Jacquin, T. and Denavit-Saubié, M., 1985, Voltage-dependent conductances in neurones of the ventrolateral NTS in rat brainstem slices, in: “Nobel Conference 1985 on Neurobiology of the Control of Breathing”, Karolinska Institutet, Stockholm, no. 32.

    Google Scholar 

  • Cloix, J. F., Grichois, M. L., Borrits, D., Sylvestre, D., Boudet, J., Guicheney, P. and Meyer, P., 1987, Comparison of biochemical properties of semi-purified Endogenous Digitalis-Like Compounds (EDLC) from human urine and hemofiltrat, Neurosci. 22: S392.

    Google Scholar 

  • Dekin, M. S. and Getting, P. A., 1984, Firing pattern of neurons in the nucleus tractus solitarius: modulation by membrane hyperpolarization, Brain Res. 324: 180.

    Article  PubMed  CAS  Google Scholar 

  • Dekin, M. S. and Getting, P. A., 1985, Pattern formation at the neuronal level: role of intrinsic membrane currents, in: “Nobel Conference 1985 on Neurobiology of the Control of Breathing”, Karolinska Institutet, Stockholm, no. 31.

    Google Scholar 

  • Denavit-Saubié, M., Champagnat, J., and Morin-Surun. M.P., 1985, Chemical transmission and central respiratory mechanismis, in: “Neurogenesis of Central Respiratory Rhythm”, A. L. Bianchi, M. Denavit-Saubié, eds., MTP Press Ltd., Lancaster.

    Google Scholar 

  • Dussardier, M., 1985, An overview of backgrounds and themes for research in neurogenesis of respiratory rhythm, in: “Neurogenesis of Central Respiratory Rhythm”, A. L. Bianchi, M. Denavit-Saubie, eds., MTP Press Ltd., Lancaster.

    Google Scholar 

  • Eccles, J. C., 1986, Chemical transmission and Dale’s principle, Progr. Brain Res. 68: 3.

    Article  CAS  Google Scholar 

  • Euler, C., von, 1986, Brain stem mechanisms for generation and control of breathing pattern, Handbook of Physiology, The Respiratory System I I, American Physiological Scociety, Washington, DC

    Google Scholar 

  • Feldman, J. L., McCrimmon, D. R., Speck, D. F., Smith, J. C., and Ellenberger, H. H., 1985, Generation of respiratory pattern in mammals, in: “Nobel Conference 1985 on Neurobiology of the Control of Breathing”, Karolinska Institutet, Stockholm, no. 29.

    Google Scholar 

  • Foutz, A. S., Boudinot, E., Morin-Surun, M.P., Champagnat, J., Gonsalves, S. F., Denavit-Saubié, M., 1987, Excitability of “silent” respiratory neurons during sleep-walking states: an iontophoretic study in undrugged chronic cats, Brain Res. 404: 10.

    Article  PubMed  CAS  Google Scholar 

  • Fuxe, K., Agnati, L. F., Härfstrand, A., Mutt, V., Anderson, K., Hökfelt, T., Vale, W., Brown, M., and River, J., 1982, Cardiovascular and respiratory actions of somatostatin peptides following intracisternal injection into the a-chloralose anesthetized rat, Neurosci. Lett., Suppl. 10: 189.

    Google Scholar 

  • Gauthier, P., Monteau, R., and Dussardier, M., 1983, Inspiratory onswitch evoked by stimulation of mesencephalic structures: a patterned response, Exp. Brain Res. 51: 261.

    Article  PubMed  CAS  Google Scholar 

  • Grunstein, M. M., Hazinski, T. A. and Schlueter, M. A., 1981, Respiratory control during hypoxia in newborn rabbits: implied action of endorphins, J. Appl. Physiol. 51: 122.

    PubMed  CAS  Google Scholar 

  • Harris-Warrick, R. M., and Flamm, R. E., 1986, Chemical modulation of a small central pattern generator circuit, Trends Neurosci. 9: 432.

    Article  CAS  Google Scholar 

  • Hedner, J., 1983, Neuropharmacological aspects of central respiratory regulation, Acta Physiol. Scand., Suppl. 524.

    Google Scholar 

  • Hökfelt, T., Johansson, 0., and Goldstein, M., 1984, Chemical anatomy of the brain, Science 225: 1326.

    Google Scholar 

  • Holaday, J. W., and Faden, A. I., 1980, Naloxone acts at central opiate receptors to reverse hypotension, hypothermia, and hypoventilation in spinal shock, Brain Res. 189: 295.

    Article  PubMed  CAS  Google Scholar 

  • Hukuhara, T., Jr., 1973, Neuronal organization of the central respiratory mechanisms in the brain stem of the cat, Acta Neurobiol. Exp. 33: 219.

    Google Scholar 

  • Iversen, L. L., 1986, Chemical signalling in the nervous system, Progr. Brain Res. 68: 15.

    Article  CAS  Google Scholar 

  • Jack, J. J. B., Redman, S.J., and Wong, K., 1981, The components of synaptic potentials evoked in cat spinal motoneurones by impulses in single group Ia afferents, J. Physiol. 321: 65.

    PubMed  CAS  Google Scholar 

  • Janczewski, W. A. and Grieb, P., 1986, Naloxone enhances respiratory output in rabbits with various brainstem sections, Bull. Europ. Physiopath. Resp. 22, Suppl.: 8.

    Google Scholar 

  • Jean, A., 1984, Brainstem organization of the swallowing network, Brain Behavior Evol. 25: 109.

    Article  CAS  Google Scholar 

  • Karczewski, W. A. and Gromysz, H., 1980, The “Split Respiratory Centre”. Lessons from brainstem transections, Adv. Physiol. Sci., vol. 10 “Respiration”, p. 587.

    Google Scholar 

  • Kessler, J. P., and Jean, A., 1986, Inhibitory influence of monoamines and brainstem monoaminergic regions in the medullary swallowing reflex, Neurosci. Letters 65: 41.

    Article  CAS  Google Scholar 

  • Kuhar, M. J., 1985, The mismatch problem in receptor mapping studies, Trends Neurosci. 27: 190.

    Article  Google Scholar 

  • Kumazawa, T., Tadaki, E. and Kim, K., 1980, A possible participation of endogenous opiates in respiratory reflexes induced by thin-fiber muscular aferents, Brain Res. 199: 244.

    Article  PubMed  CAS  Google Scholar 

  • Kurihara, M., Saavedra, J. M. and Shigematzu, K., 1987, Localization and characterization of atrial natriuretic peptide binding sites in discrete area of rat brain and pituitary gland by quantitative autoradiography, Brain Res. 408: 31.

    Article  PubMed  CAS  Google Scholar 

  • Laguzzi, R., Reiss, D. J., and Talman, W. T., 1984, Modulation of cardiovascular and electrocortical activity through serotoninergic mechanisms in the nucleus tractus solitarius of the rat, Brain Res. 304: 321.

    Article  PubMed  CAS  Google Scholar 

  • Legendre, P., McKenzie, J. S., Dupouy, B. and Vincent, J. D., 1985, Evidence for bursting pacemaker neurones in cultured spinal cord cells, Neurosci. 16: 753.

    Article  CAS  Google Scholar 

  • LlinAs, R. and Yarom, Y., 1980, Electrophysiological properties of mammalian inferior olivary cells in vitro, in: “The Inferior Olivary Nucleus: Physiology and Anatomy”, J. Courville et al., eds., Raven Press, New York.

    Google Scholar 

  • Long, S., Duff in, J., 1986, The neuronal determinants of respiratory rhythm, Progr.Neurobiol. 27: 101.

    Google Scholar 

  • Lundberg, J. M., and Hökfelt, T., 1983, Coexistence of peptides and classical neurotransmitters, Trends Neurosci. 6: 325.

    Article  CAS  Google Scholar 

  • McCrimmon, D. R., Feldman, J. L., Speck, D. F., Ellenberger, H. H., Smith, J. C. and Weese-Meyer, D., 1985, Functional heterogeneity of dorsal, ventral and pontine respiratory groups revealed by micropharmacological techniques, in: “Nobel Conference 1985 on Neurobiology of the Control of Breathing”, Karolinska Institutet, Stockholm, no. 25.

    Google Scholar 

  • McGeer, P. L., Eccles, J. C., and McGeer, E. G., 1978, “Molecular Neurobiology of Mammalian Brain”, Plenum Press, New York.

    Book  Google Scholar 

  • McQueen, D., S., 1983, Opioid peptide interactions with respiratory and circulatory systems, Br. Med. Bull. 39: 77.

    Google Scholar 

  • Millhorn, D. E., Hökfelt, T., Seroogy, K., Oertel, W., and Verhofstad, A. A. J., 1987, Immunohistochemical evidence for colocalization of gamma-aminobutyric acid and serotonin in neurons of the ventral medulla oblongata projecting to the spinal cord, Brain Res. 410: 179.

    Article  PubMed  CAS  Google Scholar 

  • Moss, I. R. and Scarpelli, E. M., 1984, CO2 and naloxone modify sleep/wake state and activate breathing in the acute fetal lamb preparation, Respir. Physiol. 55: 325.

    Article  PubMed  CAS  Google Scholar 

  • Mueller, R. A., Lundberg, D. B. A., Breese, G. R., Hedner, J., Hedner, T., and Jonason, J., 1982, The neuropharmacology of respiratory control, Pharmacol. Revs. 34: 255.

    CAS  Google Scholar 

  • Pokorski, M., Grieb, P. and Wideman, J., 1981, Opiate system influences central respiratory chemoreceptors, Brain Res. 211: 221.

    Article  PubMed  CAS  Google Scholar 

  • Quattrochi, J. J., Rho, J. H., 1985, Three-dimensional tissue reconstruction reveals integrative structural features among neurons within central respiratory centers of the brainstem, in: “Neurogenesis of Central Respiratory Rhythm”, A. L. Bianchi, M. Denavit-Saubie, eds., MTP Press Ltd., Lancaster.

    Google Scholar 

  • Robertson, H. A., Leslie, R. A., and McDonald, T. J., 1986, PYY receptors in the medulla — autoradiographic studies, in: “Neurobiology of the Nucleus of the Solitary Tract, Int. Satellite Symposium of X Annual Meeting of ENA”, Marseillie.

    Google Scholar 

  • Santiago, T. V. and Edelman, N. H., 1985, Opioids and breathing, J. Appl. Physiol. 59: 1675.

    PubMed  CAS  Google Scholar 

  • Sneddon, P., and Westfall, D. P., 1984, Pharmacological evidence that adenosine triphosphate and noradrenaline are co-transmitters in the guinea-pig vas deferens, J. Physiol. 347: 561.

    PubMed  CAS  Google Scholar 

  • Snyder, S., 1977, Opiate receptors and internal opiates, Sci. Am. 236: 44.

    Article  PubMed  CAS  Google Scholar 

  • Viala, D. and Freton, E., 1983, Evidence for respiratory and locomotor pattern generators in the rabbit cervico-thoracic cord and for their interactions, Exp. Brain Res. 49: 247.

    Article  PubMed  CAS  Google Scholar 

  • Viveros, 0. H., Diliberto, E. J., and Daniels, A. J., 1983, Biochemical

    Google Scholar 

  • and functional evidence for the cosecretion of multiple messengers from single and multiple compartments, Fed. Proc. 42: 2923.

    Google Scholar 

  • Vizi, E.S., 1984, “Non-Synaptic Interactions betwen Neurons: Modulation of Chemical Transmission”, John Wiley, New York.

    Google Scholar 

  • Wamsley, J. K., 1983, Opioid receptors: autoradiography, Pharmacol. Rev., 35: 69.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer Science+Business Media New York

About this chapter

Cite this chapter

Grieb, P. (1988). Neurotransmission and Neuromodulation Involved in the Control of Respiration. In: Karczewski, W.A., Grieb, P., Kulesza, J., Bonsignore, G. (eds) Control of Breathing During Sleep and Anesthesia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9850-0_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9850-0_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9852-4

  • Online ISBN: 978-1-4757-9850-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics