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Metabolic Fate of Endotoxin in Rat

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Endotoxin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 256))

Abstract

Endotoxins (lipopolysaccharide, LPS) of gram-negative bacteria induce numerous biological activities which, depending on concentration of endotoxin and reactivity of the host may be either harmful or beneficial (for review see 12, 23). The pathophysiological effects of endotoxin drew much attention in the past and classical endotoxin activities like pyrogenicity, leucopenia or Shwartzman reaction were studied extensively. On the other hand, questions concerning the endotoxin itself, its pathway through the organism and its ultimate fate drew little attention and remained virtually unexplored. Thus for many years it was generally believed that the organism possesses mechanisms for detoxifying endotoxin (1, 3, 17–19, 22, 30–34, 36). Evidence for this, however, was never presented.

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Author information

Authors and Affiliations

  1. Max-Planck-Institut für Immunobiologie, Freiburg, Germany

    M. Freudenberg & C. Galanos

Authors
  1. M. Freudenberg
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  2. C. Galanos
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Editor information

Editors and Affiliations

  1. The University of South Florida, Tampa, Florida, USA

    Herman Friedman  & T. W. Klein  & 

  2. Jichi Medical School, Tochigi-Ken, Japan

    Masayasu Nakano

  3. University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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© 1990 Springer Science+Business Media New York

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Freudenberg, M., Galanos, C. (1990). Metabolic Fate of Endotoxin in Rat. In: Friedman, H., Klein, T.W., Nakano, M., Nowotny, A. (eds) Endotoxin. Advances in Experimental Medicine and Biology, vol 256. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5140-6_44

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  • DOI: https://doi.org/10.1007/978-1-4757-5140-6_44

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5142-0

  • Online ISBN: 978-1-4757-5140-6

  • eBook Packages: Springer Book Archive

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