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Nephrotoxicity pp 103–106Cite as

Prevention and Reversal of Mercuric Chloride-Induced Increases in Renal Vascular Resistance by Captopril

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Abstract

By inducing ischaemia, changes in renal vascular resistance (RVR) may contribute substantially to the extent of nephrotoxic injury. The in vitro perfused rat kidney (IPRK) allows changes in RVR to be monitored precisely following nephrotoxin exposure. Mercuric chloride causes dose-dependent increases in RVR in filtering perfused rat kidneys (1) . We have examined the prevention and/or reversibility of these alterations in RVR by hydralazine, verapamil and captopril.

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References

  1. Z .H. Endre, P .J. Ratcliffe, L.G. Nicholls, J.G.G. Ledingham, J.D. Tange and G.K. Radda, 31PNMR studies of mercuric chloride nephrotoxicity in the in vitro perfused rat kidney, (this Symposium).

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  2. P .J. Ratcliffe, Z .H. Endre, L.G. Nicholls, J.D. Tange and J.G.G. Ledingham, The isolated perfused rat kidney: filtering and non-filtering models in the assessment of altered renal vascular resistance in nephrotoxicity, (this Symposium).

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Authors and Affiliations

  1. Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK

    Z. H. Endre, L. G. Nicholls, P. J. Ratcliffe & J. G. G. Ledingham

Authors
  1. Z. H. Endre
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  2. L. G. Nicholls
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  3. P. J. Ratcliffe
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  4. J. G. G. Ledingham
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Editor information

Editors and Affiliations

  1. The Robens Institute of Industrial and Environmental Health and Safety, University of Surrey, Guildford, Surrey, UK

    P. H. Bach

  2. ICI Central Toxicology Laboratory, Macclesfield, Cheshire, UK

    E. A. Lock

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© 1989 Springer Science+Business Media New York

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Endre, Z.H., Nicholls, L.G., Ratcliffe, P.J., Ledingham, J.G.G. (1989). Prevention and Reversal of Mercuric Chloride-Induced Increases in Renal Vascular Resistance by Captopril. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_16

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  • DOI: https://doi.org/10.1007/978-1-4757-2040-2_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-2042-6

  • Online ISBN: 978-1-4757-2040-2

  • eBook Packages: Springer Book Archive

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