Abstract
Upon exposure of DNA to alkylating agents a number of different lesions are produced, either directly or as a consequence of secondary modifications of the original alkylation. We have investigated the formation of one of these second lesions, single-strand DNA breaks (ssb), after treatment of cultured Chinese hamster ovary cells with four different ethylating agents: N-ethyl-N’-nitro-N-nitrosoguanidine (ENNG), N-ethyl-N-nitrosourea (ENU), ethylmethanesulfonate (EMS), and diethyl sulfate (DES).
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© 1983 Springer Science+Business Media New York
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Abbondandolo, A., Dogliotti, E., Lohman, P.H.M., Berends, F. (1983). An Attempt to Determine the Origin of DNA Single-Strand Breaks Observed after Treatment of Mammalian Cells with Alkylating Agents. In: Castellani, A. (eds) The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1117-2_44
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DOI: https://doi.org/10.1007/978-1-4757-1117-2_44
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