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Estimation of Urinary Kininogenase Activity Using Bovine Serum Low Molecular Weight Kininogen

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Kinins—II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 120))

Abstract

Estimation of urinary kininogenase activity by radioimmunoassay of generated kinin was studied. Bovine serum low molecular weight kininogen was proved not to cross-react with kallidin antibody and also bradykinin antibody. This kininogen was used as substrate measuring urinary kininogenase activity. Separation of released kinin from the kininogen was not required in the present method. Urinary kallikrein activity was found to be significantly decreased in essential hypertension, in chronic glomerulonephritis and in patients who had received renal transplantation. On the contrary, an increase in urinary kallikrein was found in primary aldosteronism and in Bartter’s syndrome. The present method was very useful for measuring kininogenase activity.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Tohoku University School of Medicine, 1-1, Seiryocho, Sendai 980, Japan

    Keishi Abe, Yataka Sakurai, Toru Itoh, Keitaro Saito, Toshiaki Haruyama, Yoichi Otsuka & Kaoru Yoshinaga

  2. Protein Research Institute, Osaka University, 1-1, Seiryocho, Sendai 980, Japan

    Hisao Kato

Authors
  1. Keishi Abe
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  2. Hisao Kato
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  3. Yataka Sakurai
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  4. Toru Itoh
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  5. Keitaro Saito
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  6. Toshiaki Haruyama
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  7. Yoichi Otsuka
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  8. Kaoru Yoshinaga
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Editor information

Editors and Affiliations

  1. Institute for Protein Research, Osaka University, Osaka, Japan

    Setsuro Fujii

  2. Science University of Tokyo, Tokyo, Japan

    Hiroshi Moriya

  3. Meiji College of Pharmacy, Tokyo, Japan

    Tomoji Suzuki

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© 1979 Springer Science+Business Media New York

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Abe, K. et al. (1979). Estimation of Urinary Kininogenase Activity Using Bovine Serum Low Molecular Weight Kininogen. In: Fujii, S., Moriya, H., Suzuki, T. (eds) Kinins—II. Advances in Experimental Medicine and Biology, vol 120. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-0926-1_11

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  • DOI: https://doi.org/10.1007/978-1-4757-0926-1_11

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-0928-5

  • Online ISBN: 978-1-4757-0926-1

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