Abstract
This presentation will focus on three apparently critical stages during the life-span of central dopaminergic neurons: (1) the vulnerable period of differentiation in pre- and early post- natal life; (2) the changes at puberty, induced by the sexual hor- mones; and (3) the decline of brain dopamine during adult life. Other monoaminergic neurons will also be discussed for the purpose of comparison.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adolfsson, R., Gottfries, C.G. and Winblad, В. (1976). Methodologi- cal aspects of postmortem investigations of human brain with special reference to monoamines and enzymes. Paper presented at Xth CINP meeting, Quebec, Canada.
Agrawal, H.C and Himwich, W.A. (1970). Aminoacids, proteins, and monoamines of developing brain. In: Developmental neurobiologys pp. 287–310. Ed. W.A. Himwich. Springfield: Ch. С. Thomas.
Ahlenius, S., Engel, J., Hard, E., Larsson, K., Lundborg, P. and Sinnerstedt, P. (1977). Open field behavior and gross motor development in offspring of nursing rat mothers given pen- fluridol. Pharmacology, Biochemistry and Behavior 6, 343–347.
Algeri, S., Ponzio, F., Bonati, M. and Brunello, N. (1976). Bio- chemical changes in monoaminergic nerves in the CNS of the senescent rat. Paper presented at Xth CINP meeting, Quebec, Canada.
Bertler, A. (1961). Occurrence and localization of catechol- amines in the human brain. Acta, physiol scand. 51, 97–107.
Bowen, D.M., Smith, C.B., White, P. and Davidson, A.N. (1976). Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. Brain 99, 459–496.
Brambilla, F., Guerrine, A., Rizzi, F. and Ricciardi, F. (1974). Psychoendocrine investigations in schizophrenia: Relation- ship between pituitary-gonadal function and behavior. Dis. Nerv. Syst. 2, 362–367.
Brody, H. (1973). Aging of the vertebrate brain. In: Development and aging in the nervous system, pp. 121–133. Eds. M. Rock- stein and M.L. Sussman. New York: Adac. Press.
Brody, K. (1977). Paper presented at Symposium on Aging, Institut de la Vie, Vichy, France.
Carlsson, A. (1977). Does dopamine play a role in schizophrenia? Psychological Medicine 7, 583–597.
Carlsson, A. and Lindqvist, M. (1978). Dependence of 5-HT and catecholamine synthesis on precursor aminoacid levels in rat brain, in preparation.
Carlsson, A., Lindqvist, M. and Kehr, W. (1974). Postmortal accu- mulation of 3-methoxytyramine in brain. Nauyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 284, 365–372.
Carlsson, A. and Winblad, B. (1976). Influence of age and time interval between death and autopsy on dopamine and 3-methoxy- tyramine levels in human basal ganglia. J. Neural Transm. 38, 271–276.
Connor, J.D. and Neff, N.H. (1970). Dopamine concentration in the caudate nucleus of the developing cat. Life Sci. 9, 1165–1168.
Davies, P. and Maloney, A.J.F. (1976). Selective loss of central cholinergic neurons in Alzheimer’s disease. Lancet ii, 1403.
Engel, J., Ahlenius, S., Almgren, O. and Carlsson, A. (1978). Effects of gonadectomy and hormone replacement on brain-mono- amine synthesis in male rats, in preparation.
Finch, C. (1976). The regulation of physiological changes during mammalian aging. Q. Rev. Biol. 51, 49–83.
Gottfries, C.G. (1978). Biochemical determinants of dementia. In: Handbook of biological psychiatry. Brain mechanisms and abnormal behavior, Vol. 2, Eds. H.H. van Praag, M.G. Lader, C.J. Rafaelsen and E.J. Sachar. New York: Marcel Dekker, Inc.
Gottfries, C.G., Gottfries, I. and Roos, B-E, (1969). The inves- tigation of homovanillic acid in the human brain and its correlation to senile dementia. Br. J. Psychiat. 225, 563–574.
Granerus, A.-K. (1977). L-Dopa treatment in Parkinson’s syndrome. Thesis. Kungälv. Sweden: Gotab.
Lehmann, J. (1966). Mental disturbances followed by stupor in a patient with carcinoidosis. Acta psychiat. scand. 42, 153 – 161.
Loizou L.A. (1972). The postnatal ontogeny of monoamine-contain- ing neurons in the central nervous system of the albino rat, Brain Res. 40, 395–418.
Lundborg, P. (1972). Abnormal ontogeny in young rabbits after chronic administration of haloperidol to the nursing mothers. Brain Res. 44,684–681.
Lundborg, P. and Engel, J. (1975). Learning deficits and selective biochemical brain changes in 4-week old offspring of nursing rat mothers treated with neuroleptics. In: Antipsychotic drugs: pharmacodynamics and pharmacokinetics, pp. 261–269. Eds. G. Sedvall, B. Uvnds and Y. Zotterman. Oxford: Per- gamon Press.
Lundborg, P. and Kellogg, C. (1973). Pharmacological approaches to monoamine receptors during brain development. In: Dy- namics of degeneration and growth in neurons, pp. 561–573. Eds. K. Fuxe, L. Olson and Y. Zotterman. Oxford: Pergamon Press.
Manshardt, J. and Wurtman, R.J. (1968). Daily rhythym in the nor- adrenaline content of rat hypothalamus. Nature 217, 574–575.
McGeer, P.L. and McGeer, E.G. (1976). Enzymes associated with the metabolism of catecholamines, acetylcholine, and gaba in human controls and Datients with Parkinson’s disease and Huntingtons chorea. J. Neurochem. 26, 65–76.
McKean, Ch. M. (1972). The effects of high phenylalanine concen- trations on serotonin and catecholamine metabolism in the human brain. Brain Res. 47, 469–476.
Perry, E.K., Perry, R.H., Blessed, G. and Tomlinson, B.E. (1977). Necropsy evidence of central cholinergic deficits in senile dementia. Lancet i, 189.
Reis, D.J., Weinbren, M. and Corvelli, A. (1968). A circadian rhythm of norepinephrine regionally in cat brain: its rels- tionship to environmental lighting and to regional diurnal variations in brain serotonin. J. Pharmac. exp. Ther. 164. 135–145.
Strombom, U., Svensson, R.J., Jackson, C.M. and Engstrom, G. (1977). Hyperthyroidism: Specifically increased response to central NA-(α-)receptor stimulation and generally increased monoamine turnover in brain. J. Neural Transm. 41, 73–92.
White, P., Goodhardt, M.J., Keet, J.P., Hiley, C.R., Carrasco, L.H. and Williams, I.E.I. (1977). Neurocortical cholinergic neurons in elderly people. Lancet i, 668.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Plenum Press, New York
About this chapter
Cite this chapter
Carlsson, A. (1978). Age-Dependent Changes in Central Dopaminergic and Other Monoaminergic Systems. In: Finch, C.E., Potter, D.E., Kenny, A.D. (eds) Parkinson’s Disease—II. Advances in Experimental Medicine and Biology, vol 113. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8893-7_1
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8893-7_1
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8895-1
Online ISBN: 978-1-4684-8893-7
eBook Packages: Springer Book Archive