Summary
Three novel trisialogangliosides of fish brain, GT3, GT2 and GT1c, have been isolated in their intact forms and their structures characterized. The discovery of these ganglioside species provides essential links for a new possible biosynthetic pathway leading to the major tetrasialoganglioside, GQ1c, of the fish brain.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Bibliography
ANDO S. and YAMAKAWA T. (1971): Application of trifluoroacetyl derivatives to sugar and lipid chemistry. I. Gas chromatographic analysis of common constituents of glycolipids. J. Biochem. 70, 335–340.
ANDO S., and YU R.K. (1977a): Isolation and characterization of human and chicken brain tetrasialeganglioside. Proc. Int. Soc. Neurochem. 6, 535.
ANDO S. and YU R.K. (1977b): Isolation and characterization of a novel trisialoganglioside, Gila, from human brain. J. Biol. Chem. 252, 6247–6250.
ANDO S. and YU R.K. (1979): Isolation and characterization of two isomers of brain tetrasialogangliosides. J. Biol.Chem. (submitted)
ANDO S., CHANG N.-C. and YU R.K. (1978): High performance thin-layer chromatography and densitometric determination of brain ganglioside composition of several species. Anal. Biochem. 89, 437–450.
ANDO S., ISOBE M. and NAGAI Y. (1976): High-performance preparative column chromatography of lipids using a new porous silica, Iatrobeads. I. Separation of molecular species of sphingolipids. Biochim. Biophys. Acta 424, 98–105.
ARCE A., MACCIONI H.J. and CAPUTTO R. (1971): The Biosynthesis of gangliosides. Biochem. J. 121, 483–493.
AVROVA N.F. (1971): Brain ganglioside patterns of vertebrates. J. Neurochem. 18, 667–674.
CUMAR F.A., FISHMAN P.H. and BRADY R.O. (1971): Analogous reactions for the biosynthesis of monosialo-and disialo-gangliosides in brain. J. Biol. Chem. 246, 5075–5084.
DICESARE J.L. and DAIN J.A. (1970): The enzymic synthesis of ganglioside. IV. UDP-N-acetylgalactosamine: (N-acetylneuraminyl)-galactosylglucosyl ceramide N-acetylgalactosaminyltransferase in rat brain. Biochim. Biophys. Acta 231, 385–393.
FISHMAN P.H. and BRADY R.O. (1976): Biosynthesis and function of gangliosides. Science, 194, 906–915.
ISHIZUKA I. and WIEGANDT H. (1972): An isomer of trisialoganglioside and the structure of tetra-and pentasialogangliosides from fish brain. Biochem. Biophys. Acta 260, 279–289.
ISHIZUKA I., KLOPPENBURG M. and WIEGANDT H. (1970): Characterization of gangliosides from fish brain. Biochim. Biophys. Acta 210, 299–305.
KAUFMAN B., BASU S. and ROSEMAN S (1968): Enzymatic synthesis of disialogangliosides from monosialogangliosides by sialyltransferases from embryonic chicken brain. J. Biol. Chem. 243, 5804–5807.
LEDEEN R.W., YU R.K. and ENG L.F. (1973): Gangliosides of human myelin: Sialosylgalactosylceramide (G7) as a major component. J. Neurochem. 21, 829–839.
MCCLUER R.H. and AGRANOFF B.W. (1972): Studies on gangliosides of goldfish brain. J. Neurochem. 19, 2307–2315.
MESTRALLET M.G., CUMAR F.A. and CAPUTTO R. (1977): Trisialoganglioside synthesis by a chicken brain sialyltransferase. Comparative study with a similar reaction for the synthesis of disialoganglioside. Molec. Cell. Biochem. 16, 63–70.
MOMOI T., ANDO S. and NAGAI Y. (1976): High resolution preparative column chromatographic system for gangliosides using DEAE-Sephadex and a new porous silica, Iatrobeads. Biochim. Biophys. Acta 441, 488–497.
RAHMANN H. (1978): Gangliosides and thermal adaptation in vertebrates. Japan. J. Exp. Med. 48, 85–96.
ROSEMAN S. (1970): The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. Chem. Phys. Lipids 5, 270–297.
SVENNERHOLM L. (1963): Chromatographic separation of human brain gangliosides. J. Neurochem. 10, 613–623.
SVENNERHOLM L. (1970): Gangliosides, in “Handbook of Neurochemistry”, LAJTHA A, Eds., Vol. 3, Plenum Press (New York), pp. 425–452.
UENO K., ANDO S. and YU R.K. (1978): Gangliosides of human, cat and rabbit spinal cords and cord myelin. J. Lipid Res. 19, 863–871.
WIEGANDT H. (1972): Recent advances on the chemistry and localization of brain gangliosides and related glycosphingolipids. Adv. Exp. Med. Biol. 25, 127–140.
YIP M.C.M. and DAIN J.A. (1970): Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceramide galactosyltransferase. Biochem. J. 118, 247–252.
YOHE H.C. and YU R.K. (1979): Biosynthesis of the novel trisialoganglioside, Gila. Trans. Amer. Soc. Neurochem. 10, 93.
YU R.K. and ANDO S. (1978): Novel gangliosides of fish brain. Trans. Amer. Soc. Neurochem. 9, 135.
YU R.K. and LEE S.H. (1976): In vitro biosynthesis of sialosylgalactosylceramide (G7) by mouse brain microsomes. J. Biol. Chem. 251, 198–203.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Plenum Press, New York
About this chapter
Cite this chapter
Yu, R.K., Ando, S. (1980). Structures of Some New Complex Gangliosides of Fish Brain. In: Svennerholm, L., Mandel, P., Dreyfus, H., Urban, PF. (eds) Structure and Function of Gangliosides. Advances in Experimental Medicine and Biology, vol 125. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7844-0_5
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7844-0_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7846-4
Online ISBN: 978-1-4684-7844-0
eBook Packages: Springer Book Archive