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Structure and Function of Gangliosides pp 487–503Cite as

Thyrotropin Receptors and Gangliosides

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 125))

Abstract

Recent studies (1, 2, 28–30, 33–35) have implicated ganglio-sides in the receptor recognition process for thyrotropin (TSH) and have led to the hypothesis (15–17, 19) that the TSH receptor is structurally and functionally related to receptors for other ligands which interact with gangliosides in vitro, i.e., cholera toxin, tetanus toxin, and interferon. This report summarizes the accumulated evidence which implicates both a glycoprotein (4, 38–40, 43) and a ganglioside in the structure and function of the TSH receptor. In the context of this symposium, particular attention will be addressed to the role of the ganglioside.

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Bibliography

  1. ALOJ S.M., KOHN L.D., LEE G. and MELDOLESI M.G. (1977): The binding of thyrotropin to liposomes containing ganglio-sides. Biochem. Biophys. Res. Commun. 74, 1053–1059.

    CAS  Google Scholar 

  2. ALOJ S.M., LEE G., CONSIGLIO E., FORMISANO S., MINTON A.P. and KOHN L.D. (1979): Dansylated thyrotropin as a probe of hormone receptor interactions. J. Biol. Chem. 254, in press.

    Google Scholar 

  3. ALOJ S.M., LEE G., GROLLMAN E.F., BEGUINOT F., CONSIGLIO E. and KOHN L.D. (1979): Role of phospholipids in the structure and function of the thyrotropin receptor. J. Biol. Chem. 254, in press.

    Google Scholar 

  4. AMIR S.M., CARRAWAY T.F. Jr., KOHN L.D. and WINAND R.J. (1972): Thyrotropin binding to thyroid plasma membranes. J. Biol. Chem. 248, 4092–4100.

    Google Scholar 

  5. BENNETT V. and CUATRECASAS P. (1977): Membrane gangliosides and activation of adenylate cyclase, in “The Specificity and Action of Animal, Bacterial, and Plant Toxins”, CUATRECASAS P. and GREAVES M.F., Eds., Chapman and Hall (London), pp. 3–66.

    Google Scholar 

  6. CHANG E.H., GROLLMAN E.F., JAY F.T., LEE G., KOHN L.D. and FRIEDMAN R.M. (1978): Membrane alterations following interferon treatment, in “Human Interferon”, STINEBRING W.R. and CHAPPLE P.J., Eds., Plenum (New York), pp. 85–99.

    Google Scholar 

  7. FORMISANO S., LEE G., JOHNSON M.L., and EDELHOCH H. (1979): Critical micelle concentrations of gangliosides. Biochemistry 18, in press.

    Google Scholar 

  8. FRIEDMAN R.M. and KOHN L.D. (1976): Cholera toxin inhibits interferon action. Biochem. Biophys. Res. Commun. 70, 1078–1084.

    CAS  Google Scholar 

  9. GROLLMAN E.F., LEE G., AMBESI-IMPIOMBATO F.D., MELDOLESI M.F., ALOJ S.M., COON H.G., KABACK H.R. and KOHN L.D. (1977): Effects of thyrotropin on the thyroid cell membrane: hyper-polarization induced by hormone-receptor interaction. Proc. Natl. Acad. Sci. U.S.A. 74, 2352–2356.

    Google Scholar 

  10. GROLLMAN E.F., LEE G., RAMOS S., LAZO P.S., KABACK H.R., FRIEDMAN R.M. and KOHN L.D. (1978): Relationships of the structure and function of the interferon receptor to hormone receptors and establishment of the antiviral state. Cancer Res. 38, 4172–4185.

    PubMed  CAS  Google Scholar 

  11. HABIG W.H., GROLLMAN E.F., LEDLEY F.D., MELDOLESI M.F., ALOJ S.M., HARDEGREE M.C. and KOHN L.D. (1978): Tetanus toxin interactions with the thyroid: decreased toxin binding to membranes from a thyroid tumor with a thyrotropin receptor defect and in Vivostimulation of thyroid function. Endocrinology 102, 844–851.

    Article  PubMed  CAS  Google Scholar 

  12. HABIG W.H., HARDEGREE M.C., GROLLMAN E.F., LEE G., RAMOS S. KOHN L.D. (1979): Interaction of tetanus toxin with thyroid membranes, in Proceedings of the 5th International Tetanus Conference, Stockholm, Sweden, June 18–23, 1978, in press.

    Google Scholar 

  13. HILL I.R., LEVIN I.W., LAZO P.S. KOHN L.D. (1979): Effect of ganglioside and ganglioside-cholera toxin interactions on the vibrational Raman spectra of the bilayer lipid in dipalmitoyl phosphatidylcholine liposomes. Biochemistry 18, in press.

    Google Scholar 

  14. JAQUES L.W., BROWN E.B., BARRETT J.M., BREY W.S. and WELLNER W. (1977): Sialic acid: a calcium binding carbohydrate. J. Biol. Chem. 252, 4533–4538.

    PubMed  CAS  Google Scholar 

  15. KOHN L.D. (1977): Characterization of the thyrotropin receptor and its involvement in Graves’ disease, in “Horizons in Biochemistry and Biophysics”, QUAGLIARIELLO E., Ed., Vol. 3, Addison-Wesley (Reading, Massachusetts ), pp. 123–163.

    Google Scholar 

  16. KOHN L.D. (1977): Relationships in the structure and function of cell surface receptors for glycoprotein hormones, bacterial toxins, and interferon, in “Annual Reports in Medicinal Chemistry”, CLARKE F.H., Ed., Vol. 12, Academic Press (New York), pp. 211–222.

    Google Scholar 

  17. KOHN L.D. (1978): Relationships in the structure and function of receptors for glycoprotein hormones, bacterial toxins, and interferon, in “Receptors and Recognition”, CUATRECASAS P. and GREAVES M.F., Eds., Series A, Vol. 5, Chapman and Hall (London), pp. 134–212.

    Google Scholar 

  18. KOHN L.D., FRIEDMAN R.M., HOLMES J.M. and LEE G. (1976): Use of thytrotopin and cholera toxin to probe the mechanism by which interferon initiates its antiviral activity. Proc. Natl. Acad. Sci. U.S.A. 73, 3695–3699.

    Article  PubMed  CAS  Google Scholar 

  19. KOHN L.D., LEE G., GROLLMAN E.F., LEDLEY F.D., MULLIN B.R., FRIEDMAN R.M., MELDOLESI M.F. and ALOJ S.M. (1978): Membrane glycolipids and their relationship to the structure and function of cell surface receptors for glycoprotein hormones, bacterial toxins, and interferon, in “Cell Surface Carbohydrate Chemistry”, HARMAN R.E. ( Ed. ), Academic Press (New York), pp. 103–133.

    Google Scholar 

  20. KUROSKY A., MARKEL D.E., PETERSON J.W. and FITCH W.M. (1977): Primary structure of cholera toxin 13-chain: a glycoprotein hormone analog? Science 195, 299–301.

    Article  PubMed  CAS  Google Scholar 

  21. LAZO P.S., GROLLMAN E.F., LEE G. and FRIEDMAN R.M. (1978): Structure:function studies of the interferon receptor. Fed. Proc. 37, 1822.

    Google Scholar 

  22. LEDLEY F.D., LEE G., KOHN L.D., HABIG W.H. and HARDEGREE M.C. (1977): Tetanus toxin interactions with thyroid plasma membranes: implications for structure and function of tetanus toxin receptors and potential pathophysiological significance. J. Biol. Chem. 252, 4049–4055.

    PubMed  CAS  Google Scholar 

  23. LEDLEY F.D., MULLIN B.R., LEE G., ALOJ S.M., FISHMAN P.H., HUNT L.T., DAYHOFF M.O. and KOHN L.D. (1976): Sequence similarity between cholera toxin and glycoprotein hormones: implications for structure activity relationship and mechanism of action. Biochem. Biophys. Res. Commun. 69, 852–859.

    CAS  Google Scholar 

  24. LEE G., ALOJ S.M., BRADY R.O. and KOHN L.D. (1976): The structure and function of glycoprotein hormone receptors: ganglioside interactions with human chorionic gonadotropin. Biochem. Biophys. Res. Commun. 73, 370–377.

    CAS  Google Scholar 

  25. LEE G., ALOJ S.M. and KOHN L.D. (1977): The structure and function of glycoprotein hormone receptors: ganglioside interactions with luteinizing hormone. Biochem. Biophys. Res. Commun. 77, 434–441.

    CAS  Google Scholar 

  26. LEE G., CONSIGLIO E., HABIG W.H., DYER S., HARDEGREE M.C. and KOHN L.D. (1978): Structure:function studies of receptors for thyrotropin and tetanus toxin: lipid modulation of effector binding to the glycoprotein receptor component. Biochem. Biophys. Res. Commun. 83, 313–320.

    CAS  Google Scholar 

  27. LEE G., CONSIGLIO E., HABIG W.H., DYER S., HARDEGREE M.C. and KOHN L.D. (1978): Structure:function studies of receptors for thyrotropin and tetanus toxin: lipid modulation of effector binding to the glycoprotein receptor component. Biochem. Biophys. Res. Commun. 83, 313–320.

    CAS  Google Scholar 

  28. LEE G., GROLLMAN E.F., ALOJ S.M., KOHN L.D. and WINAND R.J. (1977): Abnormal adenylate cyclase activity and altered gangliosides in thyroid cells from patients with Graves’ disease. Biochem. Biophys. Res. Commun. 77, 139–146.

    CAS  Google Scholar 

  29. MELDOLESI M.F., FISHMAN P.H., ALOJ S.M., KOHN L.D. and BRADY R.O. (1976): Relationship of gangliosides to the structure and function of thyrotropin receptors: their absence on plasma membranes of a thyroid tumor defective in thyrotropin activity. Proc. Natl. Acad. Sci. U.S.A. 73, 4060–4064.

    Article  CAS  Google Scholar 

  30. MELDOLESI M.F., FISHMAN P.H., ALOJ S.M., LEDLEY F.D., LEE G., BRADLEY R.M., BRADY R.O. and KOHN L.D. (1977): Separation of the glycoprotein and ganglioside components of thyrotropin receptor activity in plasma membranes. Biochem. Biophys. Res. Commun. 75, 581–587.

    CAS  Google Scholar 

  31. MOSS J., FISHMAN P.H., RICHARDS R.L., ALVING C.R., VAUGHAN M. and BRADY R.O. (1976): Choleragen-mediated release of trapped glucose from liposomes containing ganglioside GM1• Proc. Natl. Acad. Sci. U.S.A. 73, 3480–3483.

    Article  CAS  Google Scholar 

  32. MOSS J MANGANIELLO V.C. and VAUGHAN M. (1977): Hydrolysis of nicotinamide adenine dinucleotide by choleragen and its A protomer: possible role in the activation of adenylate cyclase. Proc. Natl. Acad. Sci. U.S.A. 73, 4424–4427.

    Google Scholar 

  33. MULLIN B.R., ALOJ S.M., FISHMAN P.H., LEE G., KOHN L.D. and BRADY R.O. (1976): Cholera toxin interactions with thyrotropin receptors on thyroid plasma membranes. Proc. Natl. Acad. Sci. U.S.A. 73, 1679–1683.

    Article  PubMed  CAS  Google Scholar 

  34. MULLIN B.R., FISHMAN P.H., LEE G., ALOJ S.M., LEDLEY F.D., WINAND R.J., KOHN L.D. and BRADY R.O. (1976): Thyrotropinganglioside interactions and their relationship to the structure and function of thyrotropin receptors. Proc. Natl. Acad. Sci. U.S.A. 73, 842–846.

    Article  PubMed  CAS  Google Scholar 

  35. MULLIN B.R., PACUSZKA T., LEE G., KOHN L.D., BRADY R.O. and FISHMAN P.H. (1978): Thyroid gangliosides with high affinity for thyrotropin: potential role in thyroid regulation. Science 199, 77–79.

    Article  PubMed  CAS  Google Scholar 

  36. POSS A., DELEERS M. and RUJSSCHERT J.M. (1978): Evidence for a specific interaction between GT1 ganglioside incorporated into bilayer membranes and thyrotropin binding. FEBS Letts. 86, 160–162.

    Article  CAS  Google Scholar 

  37. POSS A., DELEERS M. and RUJSSCHERT J.M. (1978): Evidence for a specific interaction between GT1 ganglioside incorporated into bilayer membranes and thyrotropin binding. FEBS Letts. 86, 160–162.

    Article  CAS  Google Scholar 

  38. TATE R.L., HOLMES J.M., KOHN L.D. and WINAND R.J. (1975): Characteristics of a solubilized thyrotropin receptor from bovine thyroid plasma membranes. J. Biol. Chem. 250, 6527–6533.

    Google Scholar 

  39. TATE R.L., SCHWARTZ H.I., HOLMES J.M., KOHN L.D. and WINAND R.J. (1975): Thyrotropin receptors in thyroid plasma membranes. J. Biol. Chem. 250, 6509–6515.

    PubMed  CAS  Google Scholar 

  40. TATE R.L., WINAND R.J. and KOHN L.D. (1976): Solubilization and partial purification of the thyrotropin receptor, in “Thyroid Research”, ROBBINS J. and BRAVERMAN L., Eds., International Congress Series No. 378, Excerpta Medica (Amsterdam), pp. 57–60.

    Google Scholar 

  41. TOSTESON M.T. and TOSTESON D.C. (1978): Bilayers containing gangliosides develop channels when exposed to cholera toxin. Nature 275, 142–144.

    Article  PubMed  CAS  Google Scholar 

  42. WADELEUX P.A., ETIENNE-DECERF J., WINAND R.J. and KOHN L.D. (1978): Effects of thyrotropin on iodine metabolism of dog thyroid cells in tissue culture. Endocrinology 102, 889–902.

    Google Scholar 

  43. WINAND R.J. and KOHN L.D. (1975): Thyrotropin effects on thyroid cells in culture: effects of trypsin on the thyrotropin-medicated cyclic 3’:5’-AMP changes. J. Biol. Chem. 250, 6534–6540.

    PubMed  CAS  Google Scholar 

  44. YOHE H.C., ROARK D.E. and ROSENBERG A. (1976): C20-Sphingosine as a determining factor in aggregation of gangliosides. J. Biol. Chem. 251, 7083–7087.

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Section on Biochemistry of Cell Regulation, Laboratory of Biochemical Pharmacology, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland, 20014, USA

    Leonard D. Kohn, Eduardo Consiglio, Marc J. S. Dewolf, Evelyn F. Grollman, Fred D. Ledley, George Lee & Nicholas P. Morris

  2. Centro di Endocrinologia ed Oncologia Sperimentale del C.N.R., Naples, Italy

    Eduardo Consiglio

  3. RUCA-Laboratory for Human Biochemistry, University of Antwerp, B2020, Antwerp, Belgium

    Marc J. S. Dewolf

Authors
  1. Leonard D. Kohn
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  2. Eduardo Consiglio
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  4. Evelyn F. Grollman
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  5. Fred D. Ledley
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  6. George Lee
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Editor information

Editors and Affiliations

  1. Psychiatric Research Centre, Department of Neurochemistry, St. Jörgen Hospital, Göteborg, Sweden

    Lars Svennerholm

  2. C. N. R. S. Center for Neurochemistry, Strasbourg, France

    Paul Mandel , Henri Dreyfus  & Paul-Francis Urban ,  & 

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© 1980 Plenum Press, New York

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Kohn, L.D. et al. (1980). Thyrotropin Receptors and Gangliosides. In: Svennerholm, L., Mandel, P., Dreyfus, H., Urban, PF. (eds) Structure and Function of Gangliosides. Advances in Experimental Medicine and Biology, vol 125. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7844-0_43

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  • DOI: https://doi.org/10.1007/978-1-4684-7844-0_43

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7846-4

  • Online ISBN: 978-1-4684-7844-0

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