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Structural Modifications of Gangliosides in Synaptic Membranes

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Structure and Function of Gangliosides

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 125))

Abstract

It has been hypothesized that neuronal gangliosides are involved in receptors for biogenic amines (1–3) and certain neuro-toxins (4,5), and it is generally, although not universally (6), believed that, in the central nervous system, gangliosides are to be found concentrated in synaptic membranes. For further information, we have prepared purified intact and hypoosmotically ruptured synaptosomes from beef brain in order to probe the structural disposition of gangliosides in these preparations by surface labelling techniques for sialosyl and galactosyl components, and we have made preliminary observations on the modifying influence of calcium ions.

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References

  1. E.G. Lapetina, E.F. Soto, and E. DeRobertis, Biochim. Biophys. Acta 135: 33–43 (1967).

    CAS  Google Scholar 

  2. D.W. Wooley, and B.W. Gommi, Nature 202: 1074 (1964).

    Article  Google Scholar 

  3. G.A. Dette, and W. Wesemann Hoppe-Seyler’s Z. Physiol. Chem. 359: 399–406 (1978).

    CAS  Google Scholar 

  4. T.B. Helting, O. Zwister, and H. Wiegandt, J. Biol. Chem. 252: 194–8 (1977).

    CAS  Google Scholar 

  5. R.W. Ledeen, and J. Mellanby, in “Perspectives in Toxicology”, ( A.W. Bernheimer, ed.) New York: Wiley (1977).

    Google Scholar 

  6. R.W. Ledeen, J. Supramol. Struct. 8: 1–17 (1978).

    Article  CAS  Google Scholar 

  7. K.C. Leskawa, H.C. Yohe, M. Matsumoto, and A. Rosenberg, Trans. Am. Soc. Neurochem. 10: 141 (1979).

    Google Scholar 

  8. K.C. Leskawa, H.C. Yohe, M. Matsumoto, and A. Rosenberg, Neurochem. Res., in press (1979).

    Google Scholar 

  9. V.P. Whittaker, and L.A. Barker, Meth. Neurochem. 2: 1–52 (1972).

    Google Scholar 

  10. G.W. Jourdian, L. Dean, and S. Roseman, J. Biol. Chem. 246: 430–5 (1971).

    CAS  Google Scholar 

  11. K. Suzuki, J. Neurochem. 12: 629–38 (1965).

    Article  CAS  Google Scholar 

  12. M.T. Vanier, M. Holm, J.E. Mansson, and L. Svennerholm, J. Neurochem. 21: 1375–84 (1973).

    Article  CAS  Google Scholar 

  13. N.F. Avrova, E.Y. Chenykaeva, and E.L. Obukhova, J. Neurochem. 20: 997–1004 (1973).

    Article  CAS  Google Scholar 

  14. J.P. Zanetta, F. Vitiello, and J. Robert, J. Chromatog. 137: 481–4 (1977).

    Article  CAS  Google Scholar 

  15. L. Svennerholm, Biochim. Biophys. Acta 24: 604–11 (1957).

    Article  PubMed  CAS  Google Scholar 

  16. J.C. Touchstone, S.S. Levin, and T. Murawec, Analyt. Chem. 43: 858–63 (1971).

    Google Scholar 

  17. C.G. Gahmberg, and L.C. Anderson, J. Biol. Chem. 252: 5888–94 (1977).

    CAS  Google Scholar 

  18. L. Svennerholm, J. Neurochem. 10: 613–23 (1963).

    Article  CAS  Google Scholar 

  19. C.G. Gahmberg, and S.-I. Hakomori, Biomembranes 8: 131–65 (1977).

    Google Scholar 

  20. C.G. Gahmberg, K. Itaya, and S.-I. Hakomori, Meth. Memb. Biol. 7: 179–210 (1976).

    CAS  Google Scholar 

  21. J. Van der Bosch, and H.M. McConnell, Proc. Natl. Acad. Sci., U.S.A. 72: 4409–13 (1975).

    Article  PubMed  Google Scholar 

  22. K. Suzuki, in “Basic Neurochemistry” ( G.J. Siegel, R.W. Albers, R. Katzman, B.W. Agranoff, eds.) Boston: Little, Brown & Co. (1976).

    Google Scholar 

  23. C.-L. Schengrund, and A. Rosenberg, J. Biol. Chem. 245: 1196–2000 (1970).

    Google Scholar 

  24. G. Tettamanti, I.G. Morgan, G. Gombos, G. Vincendon, and P. Mandel, Brain Res. 47: 515–8 (1972).

    Article  PubMed  CAS  Google Scholar 

  25. P.A. Roukema, D.H. Van den Eijnden, J. Heijlman, and G. Van der Berg, FEBS Lett. 9: 267–70 (1970).

    Article  PubMed  CAS  Google Scholar 

  26. C.-L. Schengrund, and A. Rosenberg, Biochem. 10: 2424–8 (1971).

    Article  CAS  Google Scholar 

  27. H.C. Yohe, and A. Rosenberg, Neurochem. Res. 3: 101–13 (1976).

    Article  Google Scholar 

  28. L. Warren, J. Biol. Chem. 234: 1971–5 (1959).

    CAS  Google Scholar 

  29. G. Tettamanti, F. Bonali, S. Marchesini, and V. Zambotti, Biochim. Biophys. Acta 296: 160–170 (1973).

    Article  PubMed  CAS  Google Scholar 

  30. H.C. Yohe, and A. Rosenberg, J. Biol. Chem. 252: 2412–8 (1977).

    CAS  Google Scholar 

  31. P.L. Harris, and E.R. Thornton, J. Am. Chem. Soc. 100: 6738–45 (1978).

    Article  CAS  Google Scholar 

  32. H. Hauser, A. Drake, and M.C. Phillips, Eur. J. Biochem. 62: 335–44 (1976).

    Article  PubMed  CAS  Google Scholar 

  33. S.G.A. McLaughlin, G. Szabo, and G. Eisenman, J. Gen. Physiol. 58: 667–89 (1971).

    CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biological Chemistry The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, 17033, USA

    K. C. Leskawa & A. Rosenberg

Authors
  1. K. C. Leskawa
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  2. A. Rosenberg
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Editor information

Editors and Affiliations

  1. Psychiatric Research Centre, Department of Neurochemistry, St. Jörgen Hospital, Göteborg, Sweden

    Lars Svennerholm

  2. C. N. R. S. Center for Neurochemistry, Strasbourg, France

    Paul Mandel , Henri Dreyfus  & Paul-Francis Urban ,  & 

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© 1980 Plenum Press, New York

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Leskawa, K.C., Rosenberg, A. (1980). Structural Modifications of Gangliosides in Synaptic Membranes. In: Svennerholm, L., Mandel, P., Dreyfus, H., Urban, PF. (eds) Structure and Function of Gangliosides. Advances in Experimental Medicine and Biology, vol 125. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7844-0_12

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  • DOI: https://doi.org/10.1007/978-1-4684-7844-0_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7846-4

  • Online ISBN: 978-1-4684-7844-0

  • eBook Packages: Springer Book Archive

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