Bradykininogen Synthesis by Liver

Bryan, F. T.; Ryan, J. W.; Niemeyer, R. S.

doi:10.1007/978-1-4684-7439-8_5

Bradykininogen Synthesis by Liver

F. T. Bryan³,
J. W. Ryan³ &
R. S. Niemeyer³

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 21))

Abstract

Kininogen disappears from peripheral blood after hepatectomy or intoxication with carbon tetrachloride (1), a point that suggests that kininogen is synthesized by the liver. In the present study we have tested this possibility by perfusing the isolated liver with Krebs-Henseleit solution containing ¹⁴C-arginine and ¹⁴C-proline. The radioactive protein formed by the isolated liver reacts with a specific kininogenase (2) to produce a radioactive peptide indistinguishable from bradykinin. We interpret our data to mean that kininogen is synthesized by the liver.

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References

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Authors and Affiliations

Departments of Medicine and Surgery, University of Miami School of Medicine and the Howard Hughes Medical Institute, Miami, Florida, 33152, USA
F. T. Bryan, J. W. Ryan & R. S. Niemeyer

Authors

F. T. Bryan
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J. W. Ryan
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R. S. Niemeyer
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Editors and Affiliations

Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, New York, USA
Nathan Back
Department of Clinical Pharmacology, University of Florence, Florence, Italy
F. Sicuteri

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Bryan, F.T., Ryan, J.W., Niemeyer, R.S. (1972). Bradykininogen Synthesis by Liver. In: Back, N., Sicuteri, F. (eds) Vasopeptides. Advances in Experimental Medicine and Biology, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7439-8_5

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DOI: https://doi.org/10.1007/978-1-4684-7439-8_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7441-1
Online ISBN: 978-1-4684-7439-8
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