Abstract
Aqueous extracts of mammalian gut wall were shown by Werle and his colleagues (1960) to contain a trypsin-activated hypo-:tensive activity. They called this activity a kallikrein although they presented no direct evidence that kinin release was involved. Ammdsen and Nustad (1965) noted that simple saline extracts from intestinal activity. They called this activity a kallikrein although they presented no direct evidence that kinin release was involved. Amundsen and mucosae of rats and rabbits released a smooth muscle stimulant from treated human plasma. However, they did not characterize either the smooth muscle stimulant or the nature of its release. In a recent review, Webster (1970) has suggested that the activities involved in these two studies were not, in fact, kallikreins, but other “endogenous proteases”.
This work was supported by an M.R.C. temporary research grant to Dr W. Sircus.
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References
Amundsen, E., Nustad, K. (1965) J. Physiol. 179, 479–488. Kinin-forming and destroying activities of cell homogenates.
Brown, M.E. (1960) J. Lab.Clin.Med. 55, 615–624. The colorimetric determination of arginine ester hydrolysis by human sera.
Erdós, E.G., Tague, L.L., Miwa, I. (1968) Biochem.Pharmacol. 17, 667–674. Kallikrein in granules of the submaxillary gland.
Erlanger, B.F., Kokowski, N., Cohen, W. (1961) Arch.Biochem. Biophys. 95, 271–278. The preparation and properties of two new chromogenic substrates of trypsin.
Mares-Guia, M., Silva, E., Diniz, C.R. (1970) in “Bradykinin and Related Kinins”, ed.: F. Sicuteri, M. Rocha e Silva, N. Back. New York: Plenum Press, pp. 65–75. Partial purification of rat urinary kininogenase and its reactions with active center reagents of trypsin.
Nustad, K. (1970) Br.J.Pharmac. 39, 73–86. The relationship between kidney and urinary kininogenase.
Schachter, M. (1969) Physiol.Revs. 49, 509–547. Kallikreins and kinins.
Vogel, R., Werle, E. (1970) in “Bradykinin, Kallidin and Kallikrein”, ed.: E.G. Erdos, Berlin: Springer, pp. 213–249. Kallikrein inhibitors.
Webster, M.E. (1970) in “Bradykinin, Kallidin and Kallikrein”, ed.: E.G. Erdos, Berlin: Springer, pp. 131–155. Kallikreins in glandular tissue.
Werle, E. (1960) in “Polypeptides which affect Smooth Muscle and Blood Vessels”, ed.: M. Schachter, London: Pergamon, pp. 199–209. Kallikrein, kallidin and related substances.
Zeitlin, I.J. (1970) in “Bradykinin and Related. Kinins”, ed.: F. Sicuteri, M. Rocha e Silva, N. Back, New York: Plenum Press, pp. 329–339. Kinin release associated with the gastro-intestinal tract.
Zeitlin, I.J. (1971) Br.J.Pharmac., 42, 648–649 P. Pharmacological characterisation of kinin-forming activity of the rat intestinal tract.
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© 1972 Plenum Press, New York
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Zeitlin, I.J. (1972). Rat Intestinal Kallikrein. In: Back, N., Sicuteri, F. (eds) Vasopeptides. Advances in Experimental Medicine and Biology, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7439-8_33
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DOI: https://doi.org/10.1007/978-1-4684-7439-8_33
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