Abstract
As a constituent of thyroid hormones, iodine—the heaviest element metabolized in biological materials—plays a unique and essential role in mammalian biochemistry, and, accordingly, the vast majority of research dealing with inorganic iodide (I−) has been related to this role. The biochemistry of thyroid hormones is reviewed in Chapter 6, which includes an overview of the process by which I− is incorporated into thyroid hormones through bioiodination. In this chapter, the more general aspects of the biochemistry of I− will be considered, including occurrence, uptake, biodistribution, and metabolism of I−. Transport mechanisms, in particular, the mechanisms by which the thyroid gland concentrates I−, will be reviewed as will the interaction of I− with enzymes.
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© 1991 Plenum Press, New York
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Kirk, K.L. (1991). Biochemistry of Inorganic Iodide. In: Biochemistry of the Elemental Halogens and Inorganic Halides. Biochemistry of the Elements, vol 9A+B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5817-6_5
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DOI: https://doi.org/10.1007/978-1-4684-5817-6_5
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