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The Immune Response to Viral Infections pp 109–114Cite as

Recognition of Influenza A Virus by Human Cytotoxic T Lymphocytes

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 257))

Abstract

Cytotoxic T lymphocytes (CTL) are an important component of the immune system carrying the CD8 surface glycoprotein and forming a significant part of the total lymphoid population. The role of CTL appears to be to kill cells of the body that differ from normal and this occurs during infection with intracellular parasites, particularly viruses. It is likely that CTL have evolved as a major defence mechanism against virus infections. CTL are detected in vitro by their ability to kill infected target cells that are labelled with chromium-51. There is evidence that CTL lyse infected cells in vivo (1) and they may also act by releasing lymphokines such as Interferon-Gamma (2). When infected cells are killed they can no longer replicate new virus particles, and if the cell is already doomed this is an effective way of controlling a virus infection. However the constraints on CTL antigen receptors preclude them from recognising and neutralising virus particules directly. The natural role of CTL therefore is likely to be quite distinct from that of the antibody response.

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Author information

Authors and Affiliations

  1. Institute of Molecular Medicine John Radcliffe Hospital, University of Oxford, Oxford, UK

    Andrew J. McMichael & Frances M. Gotch

Authors
  1. Andrew J. McMichael
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  2. Frances M. Gotch
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Editor information

Editors and Affiliations

  1. National Institute for Medical Research, London, UK

    B. A. Askonas

  2. National Institutes of Health, Bethesda, Maryland, USA

    B. Moss

  3. World Health Organization, Geneva, Switzerland

    G. Torrigiani

  4. Fondazione Internazionale Menarini, Florence, Italy

    S. Gorini

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© 1989 Plenum Press, New York

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McMichael, A.J., Gotch, F.M. (1989). Recognition of Influenza A Virus by Human Cytotoxic T Lymphocytes. In: Askonas, B.A., Moss, B., Torrigiani, G., Gorini, S. (eds) The Immune Response to Viral Infections. Advances in Experimental Medicine and Biology, vol 257. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5712-4_11

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  • DOI: https://doi.org/10.1007/978-1-4684-5712-4_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5714-8

  • Online ISBN: 978-1-4684-5712-4

  • eBook Packages: Springer Book Archive

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