Abstract
Colorectal cancer is the third most common cancer in North America today (1). Whereas surgery is the mainstay of primary therapy for this disease, it cures on average only 50% of all patients who develop this disease(2). The impact of surgery is greatest at the early stages of this cancer. When the tumour has penetrated to serosa or metastasized to local or distant sites the probability of cure with surgery alone is decreased markedly. In attempts to improve the prognosis for patients in this latter category, new therapies are constantly tested in the metastatic setting(3) and some are investigated in the adjuvant setting(4). We have performed a randomized trial comparing FUra to FUra and FA in patients with previously untreated metastatic colorectal cancer(5). I will describe this study and an ongoing trial of this combination in the adjuvant treatment of patients who have undergone curative resection of the colon.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Silverberg, E., Lubera, J.A., 1968, Cancer Statistics 1988, Ca- A Cancer Journal for Clinicians, 38: 5.
Surgarbaker, P., Gunderson, L.L., Wittes, R.E., 1985, Colorectal Cancer, in: Cancer Principles and Practices of Oncology, DeVita, V.T., Helleman, S., Rosenberg, S.A. ed. Lippincott Co., Toronto, 795–884.
Buroker, T.R., Moertel, C.G., Fleming, T.R. et al, 1985, A Controlled Evaluation of Recent Approaches to Biochemical Modulation or Enhancement of 5-fluorouracil therapy in Colorectal Carcinoma, J. Clin. Oncol. 3: 1624.
Wolmark, N., Fisher, B., Rockette, H. et al, 1988, Post-operative adjuvant chemotherapy or BCG for colon cancer: results of NSABP protocol C-01, J. Natl. Cancer Inst., 80: 30.
Erlichman, C., Fine, S., Wong, A., Elhakim, T., 1988, A Randomized Trial of Fluorouracil and Folinic Acid in Patients with Metastatic Colorectal Cancer, J. Clin. Oncol., 6: 469.
Kroener, J.F., Saleh, F., Howell, S.B., 1982, 5-FU and Allopurinol: Toxicity Modulation and Phase II Results in Colon Cancer, Cancer Treat. Rep., 66: 1133.
Clark, P.I., Slevin, M.L., 1985, Allopurinol mouthwashes and 5-fluorouracil induced oral toxicity, Europ. J. Surg. Oncol., 11: 267.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this chapter
Cite this chapter
Erlichman, C. (1988). 5-Fluorouracil (FUra) and Folinic Acid (FA) Therapy in Patients with Colorectal Cancer. In: Rustum, Y., McGuire, J.J. (eds) The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy. Advances in Experimental Medicine and Biology, vol 244. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-5607-3_19
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5607-3_19
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4684-5609-7
Online ISBN: 978-1-4684-5607-3
eBook Packages: Springer Book Archive