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Pharmacological Stimulation of Red Blood Cell Metabolism for High Altitude Preadaptation

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Oxygen Transport to Tissue

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 37B))

Abstract

A decrease in erythrocyte oxygen affinity is held to be an important component of high altitude adaptation. Ordinarily at 10–11,000 feet, a four to five day period or longer of exposure to high altitude is required to build-up the 2,3-diphosphoglyccrate (DPG) levels of red cells which brings about the decrease in oxygen affinity. It is during this early period of altitude exposure that symptoms (acute mountain sickness) related chiefly to the central nervous system are frequently experienced.

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References Cited

  • Brain, M.C. and Card, R.T. (1972). In “Hemoglobin and Red Cell Structure and Function” (G.J. Brewer, ed.), Advances in Experimental Medicine and Biology, Vol. 28, pp. 145–154. Plenum Press, New York.

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  • Rapoport, S. (1968). In “Essays in Biochemistry” (P.N. Campbell and G.D. Greville, eds.), Vol. 4, pp. 69–103. Academic Press, New York.

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Author information

Authors and Affiliations

  1. Departments of Anthropology, Human Genetics, and Human Performance Center, University of Michigan, Ann Arbor, Michigan, USA

    Lorna Grindlay Moore, George J. Brewer, Fred J. Oelshlegel Jr. & Andrew M. Rose

Authors
  1. Lorna Grindlay Moore
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  2. George J. Brewer
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  3. Fred J. Oelshlegel Jr.
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  4. Andrew M. Rose
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Editor information

Editors and Affiliations

  1. Clemson University, Clemson, South Carolina, USA

    Duane F. Bruley (Professor of Chemical Engineering) (Professor of Chemical Engineering)

  2. University of Arkansas Medical Center, Little Rock, Arkansas, USA

    Haim I. Bicher (Associate Professor of Pharmacology) (Associate Professor of Pharmacology)

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© 1973 Plenum Press, New York

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Moore, L.G., Brewer, G.J., Oelshlegel, F.J., Rose, A.M. (1973). Pharmacological Stimulation of Red Blood Cell Metabolism for High Altitude Preadaptation. In: Bruley, D.F., Bicher, H.I. (eds) Oxygen Transport to Tissue. Advances in Experimental Medicine and Biology, vol 37B. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-5089-7_8

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  • DOI: https://doi.org/10.1007/978-1-4684-5089-7_8

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-5091-0

  • Online ISBN: 978-1-4684-5089-7

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