Abstract
Studies from several countries over the last two centuries have shown that the chances of a fertile couple producing viable offspring in any one menstrual cycle is about 25% (Vessey et al., 1976; Short, 1979). Unfortunately little data is available on what percentage of the failure is due to ovulatory, fertilization, implantation, or developmental dysfunction. In farm animals there is a high incidence of early embryonic loss; in the case of the pig as large as 30–40%. This also appears to be the situation in the human where it has been estimated that such losses may be as high as 50% of presumed conceptions (Leridon, 1977; Short, 1979). The majority of these spontaneously aborted embryos are either genetically or morphologically abnormal. Laboratory and domestic species exhibit a behavioral period (estrus) during their reproductive cycles when females will accept males and copulate. Although the human reproductive cycle has a similar hormonal basis, acceptance of the male is not restricted to an exclusive period of behavior. It is of interest therefore that in comparison with domestic species, fecundity in humans is low. To date, the success rates achieved by IVF-ET protocols are, at 15–20%, only marginally below the accepted norm.
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References
Aitken, R. J., 1977, Changes in the protein content of mouse uterine flushings during normal pregnancy and delayed implantation, and after ovariectomy and oestradiol administration, J. Reprod. Fertil., 50:29.
Armstrong, D.T., 1968, Hormonal control of uterine lumen fluid retention in the rat, Am. J. Physiol., 214:764.
Atger, M., Mornon, J.P., Savouret, J.P., Loosfelt, H., Fridlansky, F. and Milgrom, E., 1980, Uteroglobin: A model for the study of the mechanism of action of steroid hormones, in: “Steroid Induced uterine Proteins,” M. Beato, ed., Elsevier North-Holland, Amsterdam.
Atienza-Samols, S.B., Pine, P.R. and Sherman, M.I., 1980, Effects of tunicamycin upon glycoprotein synthesis and development of early mouse embryos, Dev. Biol., 79:19.
Beier, H.M. and Beier-Hellwig, K., 1973, Specific secretory proteins of the female genital tract, Acta Endcrinol. Suppl., 180:404.
Beier, H.M., 1980, The role of uterine proteins in the establishment of receptivity of the uterus, Prog. Reprod. Biol., 7:158.
Bell, S.C., 1979, Protein synthesis during deciduoma morphogenesis in the rat, Biol. Reprod., 20:811.
Brownell, A.G., 1977, Cell surface carbohydrates of pre implantation embryos as assessed by lectin binding, J. Supramol. Struct., 7:223.
Bryce, T.H. and Teacher, J.H., 1908, Contributions to the study of early development and imbedding of the human ovum, MacLehose Glasgow.
Bullock, D.W., Kao, L.W.L. and Young, C.E., 1981, Mechanisms of induction of uterine protein synthesis: Hormonal regulation of uteroglobin, in: “Cellular and Molecular Aspects of Implantation,” S.R. Glasser and D. W. Bullock, eds., Plenum Press, New York.
Buster, J.E., Bustillo, M., Thorneycroft, I.H., Simon, J.A., Boyers, S.P., Marshall, J.R., Louw, J.A., Seed, R.W., and Seed, R.G., 1983, Non-surgical transfer of in vivo fertilized donated ova to five infertile women: Report of two pregnancies, Lancet, 2:223.
Casslen, B. and Ohlsson, K., 1981, Alpha1-antitrypsin-complexation and inactivation in the uterine fluid of IUD-users, Acta. Obstet. Gynecol. Scand., 60:103.
Catt, K.J., Dufau, M.L. and Vaitukaitis, J.L., 1975, Appearance of hOG in pregnancy plasma following the initiation of implantation of the blastocyst, J. Clin. Endocrinol. Metab., 40:537.
Clemetson, C.A.B., Kim, J.D., De Jesus, T.P.S., Mallikarjuneswara, V.R. and Wilds, J.H., 1973, Human uterine fluid potassium and the menstrual cycle, J. Ob. Gyn. Brit. Comm., 80:553.
Croxatto, H.B., Ortiz, M.E., Diaz, S., Hess, R., Balmaceda, J., and Croxatto, H.D., 1978, Studies on the duration of egg transport by the human oviduct. II. Ovum location at various intervals following luteinizing hormone peak, Am. J. Obstet. Gynecol., 132:629.
Daly, D.C., Maslar, I.A. and Riddick, D.H., 1983a, Prolactin production during in vitro decidualization of proliferative endometrium, Am. J. Obs. Gyn., 145:672.
Daly, D.C., Maslar, I.A. and Riddick, D.H., 1983b, Term decidua response to estradiol and progesterone, Am. J. Obstet. Gynecol., 145:679.
Denker, H.W., 1980, Role of proteinases in implantation, Prog. Reprod. Biol., 7:28.
Dickmann, Z., Dey, S.K. and Sen Gupta, J., 1976, A new concept: Control of early pregnancy by steroid hormones originating in the preimplantation embryo, Vitam. Horm., 34:215.
Douglass, C.P., Garrow, J.S. and Pugh, E.W., 1970, Investigations into the sugar content of endometrial secretions, J. Ob. Gyn. Brit. Comm., 77:891.
Edwards, R.G., Steptoe, P.C. and Purdy, J.M., 1980, Establishing full-term human pregnancies using cleaving embryos grown in vitro, Br. J. Obstet. Gyn., 87:737.
Enders, A.C. and Hendrickx, A.G., 1980, Morphological basis of implantation in the rhesus monkey, Prog. Reprod. Biol., 7:270.
Falk-Larson, J., 1980, Human implantation and clinical aspects, Prog. Reprod. Biol., 7:284.
Finn, C.A. and Hinchcliffe, J.R., 1965, Histological and histochemical analysis of implantation chambers in the mouse uterus, J. Reprod. Fert., 9:301.
Finn, C.A. and Martin, L., 1967, Patterns of cell division in the mouse uterus during pregnancy, J. Endocrinol., 39:593.
Fishel, S.B., 1979, Analysis of mouse uterine proteins at pro-oestrus during early pregnancy and after administration of exogenous steroids, J. Reprod. Fert., 55:91.
Flint, A.P.F., Burton, R.D., Gadsby, J.E., Saunders, P.T.K. and Heap, R.B., 1979, Blastocyst oestrogen synthesis and the maternal recognition of pregnancy, in: “Maternal Recognition of Pregnancy,” R.B. Heap and J. Whelan, eds., Ciba Foundation Symposium 64 (new series) Excerpta Medica, Amsterdam.
Glass, R.H., Spindle, A. and Pedersen, R.A., 1979, Mouse embryo attachment to substratum and interaction of trophoblast with cultured cells, J. Exp. Zool., 208:327.
Glass, R.H., Aggeler, J., Spindle, A., Pedersen, R.A. and Werb, Z., 1983, Degradation of extracellular matrix by mouse trophoblast outgrowths: A model for implantation, J. Cell Biol., 96:1108.
Glasser, S.R., 1972, The uterine environment in decidualization and implantation, in “Reproductive Biology,” H. Balen and S.R. Glasser, eds., Excerpta Medica, Amsterdam.
Glasser, S.R. and Clark, J.H., 1975, A determinant role for progesterone in the development of uterine sensitivity to decidualization and ovoimplantation, in: “The Developmental Biology of Reproduction,” C. Markert and J. Papaconstantinou, eds., Academic Press, New York.
Glasser, S.R., 1975, A molecular bioassay for progesterone and related compounds, in: “Methods in Enzymology,” Vol. 36, B. W. O’Malley and J. Hardman, eds., Academic Press, New York.
Glasser, S.R. and McCormack, S.A., 1979a, Estrogen modulated uterine gene transcription and relation to decidualization, Endocrinology, 104:1112.
Glasser, S.R. and McCormack, S.A., 1979b, Functional development of rat trophoblast and decidual cells during establishment of the hemochoreal placenta, Adv. Biosciences, 25:165.
Glasser, S.R. and McCormack, S.A., 1980, Role of stromal cell diversity in altering endometrial cell responses, in: “Blastocyst-Endometrium Relationships,” F. Leroy, C.A. Finn, A Psychoyos, P.O. Hubinont, eds., Vol. 7, Karger, Basel.
Glasser, S.R. and McCormack, S.A., 1981, Separated cell types as analytical tools in the study of decidualization and implantation, in: “Cellular and Molecular Aspects of Implantation,” S.R. Glasser and D.W. Bullock, eds., Plenum Press, New York.
Heap, R.B., Flint, A.P.F. and Gadsby, J.E., 1979, Role of embryonic signals in the establishment of pregnancy, Br. Med. Bull., 35:129.
Heap, R.B., Flint, A.P.F. and Gadsby, J.E., 1981, Embryonic signals and maternal recognition, in: “Cellular and Molecular Aspects of Implantation,” S.R. Glasser and D.W. Bullock, eds., Plenum Press, New York.
Hertig, A.T. and Rock, J., 1945, Two human ova of the pre-villous stage having a developmental age of about seven and nine days respectively, Contrib. Embryol., 31:65.
Hertig, A.T., Rock, J., Adams, E.C. and Mulligan, W.J., 1954, On the pre implant at ion stages of the human ovum, Contrlb. Embryol., 35:199.
Hertig, A.T., Rock, J. and Adams, E.C., 1956, A description of thirty-four human ova within the first seventeen days of development, Am. J. Anat., 98:435.
Heuser, C.H. and Streeter, G.L., 1941, Development of the macaque embryo, Contrib. Embryol., 29:15.
Hirsh, P.J., Fergusson, I.L.C. and King, R.J.B., 1977, Protein composition of human endometrium and its secretion at different states of the menstrual cycle, Ann. N.Y. Acad. Sci., 286:233.
Jackson, B.W., Grund, C., Schmid, E., Burki, K., Franke, W.W. and Illmensee, K., 1980, Formation of cytoskeletal elements during mouse embryogenesis, Differentiation, 17:161.
Leridon, H., 1977, “Human Fertility: The Basic Components,” University of Chicago Press, Chicago.
Lopata, A., 1983, Concepts in human in vitro fertilization and embryo transfer, Fertil. Steril., 40:289.
Maathuis, J.B. and Aitken, R.J., 1978, Cyclic variation in concentrations of protein and hexose in human uterine flushings collected by an improved technique, J. Reprod. Fert., 52:289.
MacLaughlin, D.T. and Richardson, G.S., 1983, Analysis of human uterine luminal fluid proteins following radiolabeling by reductive methylation: Comparison of proliferative and secretory phase samples, Biol. Reprod., 29:733
Markaverich, B.M., Upchurch, S., McCormack, S.A., Glasser, S.R. and Clark, J.H., 1981, Differential stimulation of uterine cells by nafoxidine and clomiphene: Relationship between nuclear estrogen receptors and type II estrogen binding sites and cellular growth, Biol. Reprod., 24:171.
Marston, J.H., Penn, R. and Sivelle, P.C., 1977, Successful autotransfer of tubal eggs in the rhesus monkey (Macaca mulatta), J. Reprod. Fert., 49:175.
Martel, D. and Psychoyos, A., 1980, Behavior of uterine steroid receptors at implantation, Prog. Reprod. Biol., 7:216–233.
Martin, L., Das, R.M. and Finn, C.A., 1973, The inhibition by progesterone of uterine cell proliferation in the mouse, J. Endocrinol., 57:549.
Martin, L., Pollard, J.W. and Fagg, B., 1976, Oestriol, Oestradrol-17 β and the proliferation and death of uterine cells, J. Endocrinol., 69:103.
Mayer, G., 1963, Delayed nidation in rats: A method of exploring the mechanisms of ovo-implantation, in: “Delayed Implantation,” A.C. Enders, ed., University of Chicago Press, Chicago.
McCormack, S.A. and Glasser, S.R., 1980, Differential response of individual uterine cell types from immature rats treated with estradiol, Endocrinology, 106:1634.
Nilsson, O., 1970, Some ultrastructural aspects of ovo-implantation, in: “Ovo-implantation, Human Gondotrophins and Prolactin,” P.O. Hubinont, F. Leroy, C. Robyn and Leleux E, eds., Karger, Basel.
Nilsson, O., 1972, Ultrastructure of the process of secretion in the rat uterine epithelium at pre implantation, J. Ultrastruct. Res., 40:572.
Noyes, R.W., Dickmann, Z., Doyle, L.L. and Gates, A.H., 1963, Ovum transfers, synchronous and asynchronous, in the study of implantation, in: “Delayed Implantation,” A.C. Enders, ed., University of Chicago Press, Chicago.
O’Grady, J.E. and Bell, S.C., 1977, The role of the endometrium in blastocyst implantation, in: “Development in Mammals,” M.H. Johnson, ed., Vol. 1, North-Holland, Amsterdam.
Parr, M.B., 1980, Endocytosis in the uterine epithelium during early pregnancy, Prog. Reprod. Biol., 7:81.
Pinsker, M.C., Sacco, A.G. and Mintz, B., 1974, Implantation-associated proteinase in mouse uterine fluids, Dev. Biol., 38:285.
Potts, M., 1966, The ultrastructure of egg implantation, Am. J. Obstet. Gynec, 96:1122.
Pratt, H.P.M., 1977, Uterine proteins and the activation of embryos from mice during delayed implantation, J. Reprod. Fert., 50:1.
Psychoyos, A., 1973, Hormonal control of ovo-implantation, Vitam. Horm., 31:201.
Psychoyos, A. and Casimiri, V., 1980, Uterine blastotoxic factors, in: “Cellular and Molecular Aspects of Implantation,” S.R. Glasser and D.W. Bullock, eds., Plenum Press, New York.
Riddick, D.H. and Daly, D.C., 1982, Decidual prolactin production in human gestation, Seminars in Preinatology, 6:229.
Roberts, G.P., Parker, J.M., and Henderson, J.R., 1976, Proteins in human uterine fluid, J. Reprod. Fertil., 48:153–157.
Sartor, P., 1980, Cell proliferation and decidual morphogenesis, Prog. Reprod. Biol., 7:115.
Saxena, B.B., Hasan, S.H., Haour, F. and Schmidt-Golloitzer, M., 1974, Radioreceptor assay of hCG: Detection of early pregnancy, Science, 184:793.
Shaman, G.B., 1963, Delayed implantation in marsupeals, in: “Delayed Implantation,” A.C. Enders, ed., University of Chicago Press, Chicago.
Sherman, M.I. and Salomon, D.S., 1975, The relationships between the early mouse embryo and its environment, in: “The Developmental Biology of Reproduction,” C.L. Markert and J. Papaconstantinou, eds., Academic Press, New York.
Sherman, M.E. and Wudl, L.R., 1976, The implanting blastocyst, in: “Cell Surface Interactions in Embryo Genesis,” G. Poste and G.A. Nicholson, eds., North-Holland, Amsterdam.
Sherman, M.I., Shalgi, R., Rizzino, A., Sellens, M.H., Gay, S., and Gary, R., 1979, Changes in the surface of the mouse blastocyst at implantation, in: “Maternal Recognition of Pregnancy,” Ciba Foundation Symposium 64 (new series) Excerpta Medica, Amsterdam.
Sherman, M.I. and Matthai, A 1980, Factors Involved in implantation-related events in vitro, Prog. Reprod. Biol., 7:43.
Short, R.V., 1979, When conception fails to become a pregnancy, in: “Maternal Recognition of Pregnancy,” Ciba Foundation Symposium 64 (new series) Excerpta Medica, Amsterdam.
Strickland, S., Reich, E. and Sherman, M.I., 1976, Plasminogen activator in early embryo genesis: Enzyme production by trophoblast and parietal endoderm, Cell, 9:231.
Surani, M.A.H., 1975, Hormonal regulation of proteins in the uterine secretion of ovarectomized rats and the implications of implantation and embryonic diapause, J. Reprod. Fert., 43:411.
Surani, M.A.H., 1979, Glycoprotein synthesis and inhibition of protein glycosylation by tunicamycin in pre implantation mouse embryos: compaction and trophoblast adhesion, Cell, 18:217.
Sylvan, P.E., MacLaughlin, D.T., Richardson, G.S., Scully, R.E. and Nikrui, N., 1981, Human uterine fluid proteins associated with secretory phase endometrium: Progesterone-induced proteins? Biol. Reprod., 24:423.
Tachi, C., Tachi, S. and Lindner, H.R., 1972, Modification by progestrone of oestradrol-induced cell proliferation, RNA synthesis and estradol synthesis in the rat uterus, J. Reprod. Fertil., 31:59.
Tickle, C., Crawley, A. and Goodman, M., 1978, Mechanism of invasiveness of epithelial tumors, J. Cell Sci., 33:133.
Vessey, M., Doll, R., Peto, R., Johnson, B. and Wiggins, P., 1976, A long term follow up study of women using different methods of contraception-an interim report, J. Biosocs. Sci., 8:373.
Weichert, C.K., 1942, The experimental control of prolonged pregnancy in the lactating rat by means of oestrogen, Anat. Rec. 83:1.
Wimsatt, W.A., 1975, Some comparative aspects of implantation, Biol. Reprod., 12:1.
Wolf, D.P. and Mastroianni, S., 1975, Protein composition of human uterine fluid, Fertil. Steril., 26:240.
Zetter, B.R., Martin, G.R., Birdwell, C.R. and Gospodarowicz, D., 1978, Role of the high molecular weight glycoprotein, Ann. New York Acad. Sci., 312:299.
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© 1984 Plenum Press, New York
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Webb, P.D., Glasser, S.R. (1984). Implantation. In: Wolf, D.P., Quigley, M.M. (eds) Human in Vitro Fertilization and Embryo Transfer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4712-5_16
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DOI: https://doi.org/10.1007/978-1-4684-4712-5_16
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