Abstract
Structural, electrochemical and biochemical derangements of skeletal muscle are exceptionally common findings in patients with severe, chronic alcoholism. Collectively, these abnormalities represent alcoholic myopathy. Studies conducted in our laboratories during the past eight years on patients and experimental animals suggest that skeletal muscle is consistently damaged by chronic exposure to ethanol1–4. In brief, prominent findings include a substantial depression of muscle cell phosphorus and magnesium content, while calcium is markedly elevated. As occurs in any injured cell, contents of sodium and chloride are elevated, while potassium tends to be reduced. These changes in muscle cell composition may occur either with or without elevated serum levels of creatine Phosphokinase (CPK) activity.
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© 1982 Plenum Press, New York
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Ferguson, E.R., Blachley, J.D., Knochel, J.P. (1982). Experimental Alcoholism Induces Phosphorus and Magnesium Deficiency in Skeletal Muscle. In: Massry, S.G., Letteri, J.M., Ritz, E. (eds) Regulation of Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 151. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4259-5_35
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DOI: https://doi.org/10.1007/978-1-4684-4259-5_35
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