Skip to main content

Effects of Hypophosphatemia on Pulmonary Muscle Performance

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 151))

Abstract

Hypophosphatemia is a disorder often characterized by muscle weakness (1). In studies of cardiac performance in hypophos-phatemic patients, O’Connor (2) found that muscle contractility could be increased by phosphate repletion. Similar results were obtained by Fuller (3) in dogs fed a phosphorus deficient diet. Studies in adult patients (4,5,6) have shown that pulmonary muscle weakness may also be associated with hypophosphatemia, although the decrease in muscle force has not been measured. We therefore investigated the effects of a dietary — induced phosphorus depletion on pulmonary muscle force in dogs.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. J. P. Knochel, The Pathophysiology and Clinical Characteristics of Severe Hypophosphatemia, Arch. Intern. Med., 137:203–220 (1977).

    Article  PubMed  CAS  Google Scholar 

  2. L. R. O’Connor, W. S. Wheeler, and J. E. Bethune, Effect of Hypophosphatemia on Myocardial Performance in Man, N. Engl. J. Med., 297:901–903 (1977).

    Article  PubMed  Google Scholar 

  3. T. J. Fuller, W. W. Nichols, B. J. Brenner and J. C. Peterson, Reversible Depression in Myocardial Performance in Dogs with Experimental Phosphorus Deficiency, J. Clin. Invest., 62:1194–1200 (1978)

    Article  PubMed  CAS  Google Scholar 

  4. J. H. Newman, T. A. Neff, and P. Ziporin, Acute Respiratory Failure Associated with Hypophosphatemia, N. Engl. J. Med., 296:1101–1103 (1973).

    Article  Google Scholar 

  5. A. J. Furlan, M. Hanson, and A. Cooperman, Acute Areflexic Paralysis, Arch. Neurol. 32:706–707 (1975).

    Article  PubMed  CAS  Google Scholar 

  6. J. R. Darsee, and D. O. Nutter, Reversible Severe Congestive Cardiomyopathy in Three Cases of Hypophosphatemia, Ann. Intern. Med., 89:867–870 (1978).

    PubMed  CAS  Google Scholar 

  7. J. W. Coburn, and S. G. Massry, Changes in Serum and Urinary Calcium During Phosphate Depletion: Studies on Mechanisms, J. Clin. Invest., 49:1073–1087 (1970).

    Article  PubMed  CAS  Google Scholar 

  8. J. Milic-Emili, J. Mead, J. M. Turner, and E. M. Glauser, Improved Technique for Estimating Pleural Pressure from Esophageal Balloons, J. Appl. Physiol., 19:207–211 (1964).

    PubMed  CAS  Google Scholar 

  9. E. Agostoni, and Rahn, Abdominal and Thoracic Pressures at Different Lung Volumes, J. Appl. Physiol., 15:1087–1092 (1960).

    PubMed  CAS  Google Scholar 

  10. M. Aubier, G. Farkas, A. DeTroyer, R. Mozes, and C. Roussos, Detection of Diaphragmatic Fatigue in Man by Phrenic Stimulation, J. Appl. Physiol., 50:538–544 (1981).

    PubMed  CAS  Google Scholar 

  11. J. Moxham, A. J. R. Morris, S. G. Spiro, R. H. T. Edwards, and M. Green, Contractile Properties and Fatigue of the Diaphragm in Man, Thorax 36:164–168 (1981).

    Article  PubMed  CAS  Google Scholar 

  12. W. H. Horl, W. Kreusser, A. Heidland, and E. Ritz, Abnormalities of Glycogen Metabolism in Cardiomyopathy of Phosphorus Depletion, in : S. G. Massry, E. Ritz, and H. Jahn, eds., New York: Plenum Press, 128:343–350 (1980).

    Google Scholar 

  13. R. H. T. Edwards, D. K. Hill, D. A. Jones, and P. A. Marton, Fatigue of Long Duration in Human Skeletal Muscle After Exercise, J. Physiol., (Lond), 272:769–778 (1977).

    CAS  Google Scholar 

  14. D. R. Rochester, N. S. Arora, S. K. Goldberg, J. McCormak, and D. Moore, Diaphragm Energy Metabolism in Acute Respiratory Failure (abstract), Physiologist, 22:107 (1979).

    Google Scholar 

  15. B. Bigland-Ritchie, D. A. Jones, and J. J. Woods, Excitation Frequency and Muscle Fatigue: Electrical Responses During Human Voluntary and Stimulated Contractions, Exper. Neur., 64:414–427 (1979)

    Article  CAS  Google Scholar 

  16. D. A. Jones, B. Bigland-Ritchie, and R. T. Edwards, Excitation Frequency and Muscle Fatigue: Mechanical Responses During Voluntary and Stimulated Contractions, Exper. Neur., 64:401–413 (1979).

    Article  CAS  Google Scholar 

  17. T. J. Fuller, N. W. Carter, C. Barcenas, and J. P. Knochel, Reversible Changes in the Muscle Cell in Experimental Phosphorus Deficiency, J. Clin. Invest., 57:1019–1024 (1976)

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Planas, R.F., McBrayer, R.H., Koen, P.A. (1982). Effects of Hypophosphatemia on Pulmonary Muscle Performance. In: Massry, S.G., Letteri, J.M., Ritz, E. (eds) Regulation of Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 151. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4259-5_34

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4259-5_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4261-8

  • Online ISBN: 978-1-4684-4259-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics