Abstract
There is experimental evidence from both.in vitro and in vivo studies for three main effects of hypophosphatemia and phosphate depletion on bone. These are — an increase in osteoclastic resorption,1,3 a decrease in the rate of collagen synthesis by osteoblasts, 3,4 and defective bone mineralization.3,5 Studies in the intact rat using tetracycline labeling were reviewed by Ivey and colleagues at a previous Phosphate Workshop.6 This paper summarizes the relationship between osteoblast function studied by double tetracycline labeling7 and plasma inorganic phosphate (P) in various human metabolic bone diseases associated with chronic hypophosphatemia.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
L. G. Raisz and I. Niemann, Effect of phosphate, calcium and magnesium on bone resorption and hormonal responses in tissue culture. Endocrinology 85:446 (1969).
P. Cuisineir-Gleizes, M. Thomassett, Sainteny-Debove, et al, Phosphorus deficiency, parathyroid hormone and bone resorption in the growing rat. Calcif Tiss Res 20:235 (1976).
D. Baylink, J. Wergedal, and M. Stauffer, Formation, mineralization, and resorption of bone in hypophosphatemic rats. J Clin Invest 50:2519 (1971).
L. G. Raisz, J. W. Dietrich, and D. Maina, Effects of phosphate on bone formation and resorption in tissue culture. in: “Phosphate Metabolism, Kidney and Bone,” L. Avioli, Ph. Bordier, H. Fleish, S. Massry, E. Slatopolsky, ed., Armour Montagu, Paris (1976).
L. R. I. Baker, P. Ackrill, W. R. Cattell, T. C. B. Stamp, and L. Watson, Iatrogenic osteomalacia and myopathy due to phosphate depletion, Br Med J 3:150 (1974).
J. L. Ivey, E. R. Morey, and D. J. Baylink, The effects of phosphate depletion on bone, Adv Exp Biol Med 103:373 (1978).
A. M. Parfitt, C. Mathews, D. Rao, B. Frame, M. Kleereloper, and A.R. Villanueva, Impaired osteoblast function in metabolic bone disease, in: “Osteoporosis: Recent Advances in Pathogenesis and Treatment.” H. F. DeLuca, H. Frost, W. Jee, C. Johnston, and A. M. Parfitt, ed., University Park Press, Baltimore (1981).
A. M. Parfitt, The physiologic and clinical significance of bone histomorphometric data, in: “Bone Histomorphometry. Techniques and Interpretations, R. Recker, ed., C. R. C. Press (in press).
A. R. Villanueva, Part II. Basic preparation and staining ofundecalcified bone, in: “Theory and Practice of Histotechnology,” 2nd Edition, D. C. Sheehan, B. B. Hrapchak, C. V. Mosby, St. Louis (1980).
F. Meisen and L. Mosekilde, Tetracycline double-labeling of iliac trabecular bone in 41 normal adults, Calcif Tiss Res 26:99 (1978).
M. C. de Vernejoul, L. Cancela, J. Gueris, J. L. Gardin, J. Bielakoff, D. Kuntz, A. Ryckewaert, and L. Miravet, Correlation between bone disease and 1,25-dihydroxy vitamin D in primary hyperparathyroidism, Min and Electrolyte Metab 6:270 (1981).
A. M. Parfitt and M. Kleerekoper, The divalent ion homeostatic system: Physiology and metabolism of calcium, phosphorus magnesium and bone, in: “Clinical Disorders of Fluid and Electrolyte Metabolism.” M. Maxwell, C. R. Kleeman, 3rd Edition (1980).
D. J. Baylink, E. R. Morey, J.L. Ivey, and M. E. Stauffer, Vitamin D and bone, in: “Molecular Biology and Clinical Nutrition, A. W. Norman, ed., Marcel Dekker, Inc., New York (1980).
M. Kleerekoper, R.S. Bernstein, C. Cruz, N.W. Levin and A. M. Parfitt, Parathyroid hormone resistance in renal allograft recipients, Min and Electrolyte Metab, 6:246 (1981).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Parfitt, A.M., Villanueva, A.R. (1982). Hypophosphatemia and Osteoblast Function in Human Bone Disease. In: Massry, S.G., Letteri, J.M., Ritz, E. (eds) Regulation of Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 151. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4259-5_27
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4259-5_27
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4261-8
Online ISBN: 978-1-4684-4259-5
eBook Packages: Springer Book Archive