Coronaviruses

1. Front Matter

   Pages i-xii

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2. Coronaviruses: A Historical Perspective

   1. Coronaviruses: A Historical Perspective

      • Leslie P. Weiner

      Pages 1-5

3. Molecular Biology of Coronaviruses

   1. Molecular Biology of Coronavirus 1986

      • Michael M. C. Lai

      Pages 7-13

   2. The Complete Nucleotide Sequence of Avian Infectious Bronchitis Virus: Analysis of the Polymerase-Coding Region

      • M. E. G. Boursnell, T. D. K. Brown, I. J. Foulds, P. F. Green, F. M. Tomley, M. M. Binns

      Pages 15-29

   3. Sequence and Structure of the Coronavirus Peplomer Protein

      • R. J. de Groot, J. A. Lenstra, W. Luytjes, H. G. M. Niesters, M. C. Horzinek, B. A. M. van der Zeijst et al.

      Pages 31-38

   4. Identification of the Coronavirus MHV-JHM mRNA 4 Gene Product Using Fusion Protein Antisera

      • Dora Ebner, Stuart Siddell

      Pages 39-45

   5. Identification of a New Gene Product Encoded by mRNA D of Infectious Bronchitis Virus

      • A. R. Smith, M. E. G. Boursnell, M. M. Binns, T. D. K. Brown, S. C. Inglis

      Pages 47-54

   6. Expression of Porcine Transmissible Gastroenteritis Virus Genes in E. Coli as β-Galactosidase Chimaeric Proteins

      • Paul Britton, David J. Garwes, Kevin Page, Jean Walmsley

      Pages 55-64

   7. Sequences Involved in the Replication of Coronaviruses

      • P. J. Bredenbeek, J. Charite, J. F. A. Noten, W. Luytjes, M. C. Horzinek, B. A. M. van der Zeijst et al.

      Pages 65-72

   8. Murine Coronavirus 5′-End Genomic RNA Sequence Reveals Mechanism of Leader-Primed Transcription

      • Lisa H. Soe, Chien-Kou Shieh, Shinji Makino, Ming-Fu Chang, Stephen A. Stohlman, Michael M. C. Lai

      Pages 73-81

   9. Expression of the E1 Gene of Mouse Hepatitis Virus (MHV A59) In Vivo and In Vitro

      • Heiner Niemann, Thomas Mayer, Manfred Wirth, Teruko Tamura

      Pages 83-97

   10. RNA Recombination of Coronavirus

       • James G. Keck, Shinji Makino, Lisa H. Soe, John O. Fleming, Stephen A. Stohlman, Michael M. C. Lai

       Pages 99-107

   11. Surface Glycoproteins of Transmissible Gastroenteritis Virus: Functions and Gene Sequence

       • Denis Rasschaert, Bernard Delmas, Bernard Charley, Jeanne Grosclaude, Jacqueline Gelfi, Hubert Laude

       Pages 109-116

   12. Nucleotide Sequence of the Porcine Transmissible Gastroenteritis Coronavirus Matrix Protein Gene

       • Paul A. Kapke, Frank Y. C. Tung, David A. Brian, Roger D. Woods, Ronald Wesley

       Pages 117-122

   13. Deduced Amino Acid Sequence and Potential O-Glycosylation Sites for the Bovine Coronavirus Matrix Protein

       • William Lapps, Brenda G. Hogue, David A. Brian

       Pages 123-129

   14. Glycosylation of the Bovine Coronavirus Hemagglutinin Protein

       • Brenda G. Hogue, David A. Brian

       Pages 131-136

   15. Studies into the Mechanism of MHV Transcription

       • Ralph S. Baric, Chien Kou Shieh, Stephen A. Stohlman, Michael M. C. Lai

       Pages 137-149

   16. Expression of IBV Spike Protein by a Vaccinia Virus Recombinant

       • Fiona Tomley, Matthew Binns, Mike Boursnell, Adrian Mockett

       Pages 151-153

   17. Translation and Processing of MHV-A59 Virion RNA in Reticulocyte Lysates and Infected Cells

       • Mark Denison, Stanley Perlman

       Pages 155-156

   18. Temporal Regulation of RNA Synthesis of Bovine Coronavirus

       • James G. Keck, Brenda G. Hogue, David A. Brian, Michael M. C. Lai

       Pages 157-158

Coronaviruses have emerged during the past ten years from being a group of viruses causing a variety of minor veterinary and human diseases to a major virus group of both clinical significance and molecular biological interest. Against this background, two international coronavirus symposia were held in 1980 and 1983. In recent years, the pace of coronavirus research has been quickened even more by infusion of recombinant DNA technology and establishment of various animal model systems to study the pathogenesis and immunology of coronavirus infections. We therefore organized the Third International Coronavirus Symposium held at Asilomar, California in September 1986, which was attended by more than 120 participants representing a cross­ section of both academia and industry. This symposium provided an exciting and stimulating forum for assessing the progress made since the last triennial symposium in Netherlands and to suggest the directions for future efforts. This volume collects the scientific papers presented in this symposium. Three loosely defined areas, Molecular biology, Virus-Cell Interaction and Viral Pathogenesis, are separated. These papers very nicely summarize the current status of coronavirus research. They contain a large amount of sequence data, including the complete sequence of a 27 Kb coronavirus genome, a novel mechanism of mRNA synthesis that is unique to coronviruses, and many exciting aspects of coronavirus pathogenesis and immunology. Reflecting the growing interest in the preparation of vaccines, several papers also address the issues related to coronavirus vaccines, which is an area new to this symposium. Dr.

• immunology
• infection
• molecular biology
• pathogenesis
• vaccine
• virus

• University of Southern California School of Medicine, Los Angeles, USA

  Michael M. C. Lai, Stephen A. Stohlman

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