Summary
The effect of bradykinin (BK) and some analogues of BK on the human blister base was studied. BK produced reproducible dose-related increases in pain responses. A characteristic delay, which was not dose-related occurred between application of BK and the resultant response. The rank order of potency of several kinin analogues on the pain resuonse was BK >>>Σ-cyclo-(Lys-Gly 6)-BK = Σ-cyclo-kallidin > des-Arg -BK. No increase in pain response was seen9With repeated application of the selective B1-receptor agonist des-Arg -BK to the same bl9ister8 base at 4h intervals. The B1 receptor antagonist des-Arg -Leu -BK was without effect against BK-induced responses. The B?-receptor antagonists, D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Phe-Thi-Arg-TFA and D-Pro-Phe-Arg-heptylamide produced significant antagonism of the bradykinin-induced pain responses at doses which had no effect against 5-hydroxytryptamine or potassium chloride. It is concluded that the kinin receptor mediating pain on the human blister base is of the B2 type.
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© 1989 Plenum Press, New York
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Whalley, E.T., Clegg, S., Stewart, J.M., Vavrek, R.J. (1989). Antagonism of the Algesic Action of Bradykinin on the Human Blister Base. In: Abe, K., Moriya, H., Fujii, S. (eds) Kinins V. Advances in Experimental Medicine and Biology, vol 247 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9543-4_38
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DOI: https://doi.org/10.1007/978-1-4615-9543-4_38
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