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Effects of Mineralocorticoid on Kininase Activity Along the Distal Nephron Segments of the Rat

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Kinins V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 247 A))

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Abstract

The kallikrein-kinin system is known to have natriuretic action in the kidney. What is the rate limiting factor in the action of kinin? Is that the kallikrein activity, kininogen concentration, or kininase activity? There are discrepancies between urinary kallikrein activity and urinary kinin excretion in some reports. Kininogen may not be the rate limiting factor in usual condition because kininogen could be measured in the final urine. In this meaning, kininase can be considered as potential candidate as the rate limiting factor in the kallikrein-kinin system of the kidney.

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Author information

Authors and Affiliations

  1. 2nd Department of Internal Medicine, Tokyo Medical and Dental University, 5-45, Yushima 1-chome, Bunkyo-ku, Tokyo, Japan

    Kimio Tomita, Kazutomo Ujiie, Yoshitaka Maeda, Yasuhiko Iino & Naoki Yoshiyama

  2. Toride Kyodo Hospital, 5901-1, Oaza Terada, Toride-shi Ibaraki, Japan

    Tatsuo Shiigai

Authors
  1. Kimio Tomita
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  2. Kazutomo Ujiie
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  3. Yoshitaka Maeda
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  4. Yasuhiko Iino
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  5. Naoki Yoshiyama
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  6. Tatsuo Shiigai
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Editor information

Editors and Affiliations

  1. Tohoku University School of Medicine, Sendai, Miyagi, Japan

    Keishi Abe

  2. Science University of Tokyo, Tokyo, Japan

    Hiroshi Moriya

  3. The Osaka Foundation for Promotion of Fundamental Medical Research, Otsu, Shiga, Japan

    Setsuro Fujii

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© 1989 Plenum Press, New York

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Tomita, K., Ujiie, K., Maeda, Y., Iino, Y., Yoshiyama, N., Shiigai, T. (1989). Effects of Mineralocorticoid on Kininase Activity Along the Distal Nephron Segments of the Rat. In: Abe, K., Moriya, H., Fujii, S. (eds) Kinins V. Advances in Experimental Medicine and Biology, vol 247 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9543-4_25

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  • DOI: https://doi.org/10.1007/978-1-4615-9543-4_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9545-8

  • Online ISBN: 978-1-4615-9543-4

  • eBook Packages: Springer Book Archive

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