Abstract
Infectious disease including those caused by viruses, rickettsia, fungi, parasites and bacteria are known to be associated with hemostatic disorders1 including disseminated intravascular coagulation (DIC). This paper will concentrate on the pathogenesis of the coagulation abnormalities in particular changes in surface mediated events of plasma proteolysis. Most of the work that will be discussed will concern our studies on gram-negative septicemia since this is the most dramatic of the infectious disorders, and on typhoid fever in which controlled observations have been made. A new approach to therapy using a genetically engineered protease inhibitor will be illustrated in an animal model.
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© 1989 Plenum Press, New York
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Colman, R.W. (1989). Kallikrein-Kinin System in Infectious Diseases. In: Abe, K., Moriya, H., Fujii, S. (eds) Kinins V. Advances in Experimental Medicine and Biology, vol 247 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9543-4_21
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DOI: https://doi.org/10.1007/978-1-4615-9543-4_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9545-8
Online ISBN: 978-1-4615-9543-4
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