Abstract
The anticoagulant property of heparin was first recognized by McLean (1916) during an investigation of the properties of chloroform extracts of various tissues. The name heparin was given to this material because of its hepatic origins. Plasma cofactor was shown to be necessary for its activity by Howell and Holt (1918) and purified heparin polysaccharide was first isolated by Howell (1925). The development of heparin for clinical research took place over forty years ago by research groups in Toronto and Stockholm (Jorpes 1939; Murray et al., 1937) and has now become universally used as an essential anticoagulant during surgery and enjoys widespread use in the control and prevention of thromboembolism postoperatively.
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© 1985 Plenum Press, New York
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Denton, J., Lane, D.A. (1985). The Anticoagulant Properties of Fractionated and Depolymerized Heparins. In: Cajozzo, A., Perricone, R., Di Marco, P., Palazzolo, P. (eds) Advances in Hemostasis and Thrombosis. Ettore Majorana International Science Series, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9424-6_24
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DOI: https://doi.org/10.1007/978-1-4615-9424-6_24
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