Abstract
Cardiovacular complications are very common in patients with diabetes mellitus and play an important role in the natural history of diabetes. Therefore, many investigations were directed toward the study of the genesis of such complications. Platelets and blood clotting have been investigated in the light of their possible importance in the development of occlusive vascular disease. However, in spite of extensive investigations in this field, the well defined knowledge of hemostatic changes, and of their relationship with diabetes and its vascular complications is still relatively little. This probably depends on the fact that diabetes is still an heterogeneous syndrome resulting from a number of causes; moreover, its severe metabolic changes can by themselves affect platelet and clotting functions, and clinically undetectable complications may represent both a cause and an effect of hemostatic changes.
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References
Abbate, R., Navalesi, R., Benzi, L., Fortini, A., Gensini, G.F., and Neri Serneri, G.G., 1981, Platelet functions in patients at thrombotic risk, Italian National Research Council-Atherosclerosis Project Meeting, Rome.
Almer, L.O., and Nilsson, I.M., 1975, On Fibrinolysis in diabetes mellitus, Acta Med. Scand., 198: 101.
Badawi, H., El-Sawy, M., and Mikhai, M., 1970, Platelets, coagulation and fibrinolysis in diabetic and non-diabetic patients with quiescent coronary heart disease, Angiology, 21: 511.
Bensoussan, D., Levy-Toledano, S., and Passa, P., 1975, Platelet hyperaggregation and increased plasma level of von Willebrand factor in diabetics with retinopathy, Diabetologia, 11: 307.
Bern, M.M., 1978, Platelet functions in diabetes mellitus, Diabetes, 27: 342.
Borkenstein, M.H., and Muntean, W.E., 1982, Elevated factor VIII activity and factor VIII-related antigen in diabetic children without vascular disease, Diabetes, 31: 1006.
Burrows, A.W., Chavin, S.I., and Hockaday, T.D., 1978, Plasma beta-thromboglobulin in concentrations in diabetes mellitus, Lancet, i: 235.
Butkus, A., Skrinska, V.A., and Schumaker, O.P., 1980, Thromboxane production and platelet aggregation in diabetic subjects with clinical complications, Thromb. Res., 19: 211.
Colwell, A., Kalushka, P.V., Sarji, K.E., Levine, J., Sagel, J., and Nair, R.M.G., 1976, Altered platelet function in diabetes mellitus, Diabetes, 25: 826.
Corbella, E., Miragliotta, G., Masperi, R., Villa, S., Bini, A., de Gaetano, G., and Chiumello, G., 1979, Platelet aggregation and antithrombin III levels in diabetic children, Haemostasis, 8: 30.
Davì, G., Rini, G.B., Averna, M., Novo, S., Di Fede, G., Pinto, A., Notarbartolo, A., and Strano, A., 1982, Thromboxane B2 formation and platelet sensitivity to prostacyclin in insulin-dependent and insulin-independent diabetes, Thromb. Res., 26: 359.
Fleischman, A.I., Marvin, L., Bierenbaum, A.S., Somol, S.L., and Watson, P.B., 1976, in vivo platelet function in diabetes mellitus, Thromb. Res., 9: 467.
Fuller, J.H., Keen, H., Jarrett, R.J., Orner, T., Meade, T.W., Chakrabarti, R., North, V.R., and Stirling, Y., 1979, Hemostatic variables associated with diabetes and its complications, Br. Med. J., ii: 964.
Gensini, G.F., Abbate, R., Favilla, S., and Neri Serneri, G.G., 1979, Changes of platelet function and blood clotting in diabetes mellitus, Thromb. Haemost., 42: 983.
Giustolisi, R., Musso, R., Russo, M., Catania, N., Lombardo, T., and Cacciola, E., 1982, Possible evidence for an increased factor VIII antigen synthesis in vascular endothelium of diabetic subjects, Thromb. Haemost., 47: 293.
Halushka, P.V., Rogers, R.C., Loadholt, C.B., and Colwell, J.A., 1981, Increased platelet thromboxane synthesis in diabetes mellitus, J. Lab. Clin. Med., 97: 87.
Hellem, A.J., Skalhegg, B.A., and Odegard, A.E., 1964, The platelet adhesiveness in plasma from diabetic and lipemic patients, Sangre, 9: 175.
Kwaan, H.C., Colwell, J.A., Cruz, S., Suwanwella, N., and Dobbie, J.G., 1972, Increased platelet aggregation in diabetes mellitus, J. Lab. Clin. Med., 80: 236.
Leone, G., Bizzi, B., Accorrà, F., and Boni, P., 1974, Functional aspects of platelets in diabets mellitus, in: “Platelet Aggregation and Drugs,” L. Caprino and E.C. Rossi, eds., Academic Press, New York, p. 49.
Malhotra, K.C., Arya, R.K., Chugh, S.N., and Singla, B.B., 1982, Status of platelets in complicated and uncomplicated diabetes mellitus, Angiology, 33: 410.
Neri Serneri, G.G., Abbate, R., Gensini, G.F., and Mugnaini, C., 1976, Increased platelet aggregation due to a plasmatic aggregating activity (factor Xa?), Eur. Symp. Adv. Coagulation, Fibrinolysis, Platelet aggregation and Atherosclerosis, Palermo.
Neri Serneri, G.G., Abbate, R., Gensini, G.F., Masotti, G., Mannucci, P.M., and Strano, A., 1979, aterosclerosi e stati trombo-filici, Relazione all’80° Congr. Naz. Soc. It. Med. Interna, ed., Pozzi, Roma.
Neri Serneri, G.G., Abbate, R., Mugnaini, C., and Gensini, G.F., 1980, Increased platelet aggregation due to a plasma-aggregating activity. Identification of the responsible factors, Haemostasis, 9: 141.
Preston, F.E., Ward, J.D., Marcola, B.H., Porter, N.R., Timperley, W.R., and O’Malley, B.C., 1978, Elevated beta-thromboglobulin levels and circulating platelet aggregates in diabetic microangiopathy, Lancet, i: 238.
Preston, F.E., 1982, Disorders of haemostasis in diabetes mellitus, La Ricerca Clin. Lab., 12: 425.
Sagel, J., Colwell, J.A., Crook, L., and Laimins, M., 1975, Increased platelet aggregation in early diabetes mellitus, Ann. Intern, Med., 82: 733.
Silberbauer, K., Schernthaner, G., Sinzinger, H., Piza-Katzer, H., and Winter, M., 1979, Decreased vascular prostacyclin in juvenile-onset diabetes, New Engl. J. Med., 300: 366.
Takeda, H., Maeda, H., Fukushima, H., Nakamura, N., and Uzawa, H., 1981, Increased platelet phospholipase activity in diabetic subjects, Thromb. Res., 24: 131.
Tindall, H., Paton, R.C., Zuzel, M., and McNicol, G.P., 1981, Platelet life span in diabetics with and without retinopathy, Thromb. Res., 21: 641.
Tsianos, E.B., and Stathakis, N.E., 1980, Soluble fibrin complexes and fibrinogen heterogeneity in diabetes mellitus, Thromb. Haemost., 44: 130.
Van Zile, J., Kilpatrick, M., Laimius, M., Sagel, J., Colwell, J.A., and Virella, G., 1981, Platelet aggregation and release of ATP after incubation with soluble immune complexes purified from the serum of diabetic patients, Diabetes, 30: 575.
Zahavi, J., Jones, N.A.G., Betteridge, D.J., Leyton, J., Galton, D.J., Clark, S.E., and Kakkar, V.V., 1979, Platelet factor 4, beta-thromboglobulin, malondialdehyde formation and blood lipids in patients with diabetes mellitus, Thromb. Haemost., 42: 334.
Ziboh, V., Maruta, H., Lord, J., Cagli, W.D., and Lucky, W., 1979, Increased biosynthesis of thromboxane A2 by diabetic patients, Eur. J. Clin. Invest., 9: 223.
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© 1985 Plenum Press, New York
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Gensini, G.F. (1985). Hemostatic Alterations in Diabetes Mellitus. In: Cajozzo, A., Perricone, R., Di Marco, P., Palazzolo, P. (eds) Advances in Hemostasis and Thrombosis. Ettore Majorana International Science Series, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9424-6_19
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DOI: https://doi.org/10.1007/978-1-4615-9424-6_19
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