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Critical Review of Myocardial Infarction Prevention with Antiaggregants

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Advances in Hemostasis and Thrombosis

Part of the book series: Ettore Majorana International Science Series ((LIFESCI,volume 20))

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Abstract

Myocardial infarction (MI) is the result of a low process of narrowing of the coronary vessels and an acute thrombotic event. The most rational approach to MI prevention should, therefore, be the prevention of coronary atheroma. However, although experimental data exist which indicate that antiaggregants are effective in preventing the formation of atherosclerotic lesions, and although a clinical study with a 5-year follow-up is presently being performed on the use of antiaggregants in inhibiting the angiographic progression of coronary scl erosis (1), at the present time the prevention of coronary atheroma does not seem to be clinically realistic. For this reason, research has been directed towards prevention of thromboocclusive events in the coronary vessels.

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References

  1. M. Verstraete, Registry of prospective clinical trials, fifth report, Thromb. Haemost., 48: 1–5 (1982).

    Google Scholar 

  2. N.L. Baezinger, M.J. Dillender, and P.W. Majerus, Cultured human skin fibroblasts and arterial cells produce a labile platelet-inhibitory prostaglandin, Biochem. Biophys. Res. Commun., 78: 294–301 (1977).

    Article  Google Scholar 

  3. G.J. Roth, N. Stanford, and P.W. Majerus, Acetylation of prostaglandin synthase by aspirin, Proc. Natl. Acad. Sci. USA, 72: 3073–3076 (1975).

    Article  ADS  Google Scholar 

  4. R.M. Robertson, D. Robertson, and L.J. Roberts, Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitory trials, N. Engl. J. Med., 304: 998 (1981).

    Article  Google Scholar 

  5. S. Chierchia, R. De Caterina, F. Crea, C. Patrono, and A. Maseri, Failure of thromboxane A blockade to prevent attacks of vasospastic angina, Circulation, 66: 702–705 (1982).

    Article  Google Scholar 

  6. M. Ali and J.W.D. McDonald, Effects of sulfinpyrazone on platelet prostaglandin synthesis and platelet release reaction, J. Lab. Clin. Med., 89: 868–875 (1977).

    Google Scholar 

  7. E.D. Maguire, G.F. Pay, R.B. Wallis, and A.M. White, Prolonged inhibition of ex vivo sodium arachidonate-induced platelet aggregation and malondialdehyde (MDA) production by sulfinpyrazone (Anturane) in man, Thromb. Res., 21: 321–327 (1981).

    Article  Google Scholar 

  8. J.L. Gordon and J.D. Pearson, Effects of sulfinpyrazone and aspirin on prostaglandin I2 synthesis by endothelial cells, Br. J. Haematol., 64: 481–483 (1978).

    Google Scholar 

  9. M. Livio, S. Villa, and G. De Gaetano, Long-lasting inhibition of platelet prostaglandin but normal vascular prostacyclin generation following sulfinpyrazone administration to rats, J. Pharm. Pharmcol., 32: 718 (1980).

    Article  Google Scholar 

  10. P. Steele, M. Weily, J. Rainwater, and R. Vogel, Platelet survival time and thromboembolism in patients with mitral valve prolapse, Circulation, 60: 43–54 (1979).

    Article  Google Scholar 

  11. M. Cortellaro, C. Boschetti, G. Fassio, M. Basagni, and E.E. Polli, A controlled study of the effect of sulfinpyrazone on platelet survival and on platelet-bound 14C-serotonin release in patients with previous myocardial infarction, Acta Haematol., 61: 68–74 (1979).

    Article  Google Scholar 

  12. S. Moncada and R. Korbut, Dipyridamole and other phospho-diesterase inhibitors act as antithrombotic agents by potentiating endogenous prostacyclin, Lancet, i: 1286–1289 (1978).

    Article  Google Scholar 

  13. A. Maseri, Pathogenesis of the clinical events in ischemic-heart disease, in: “Secondary Prevention of Ischemic Cardiac Events: Present Status and New Perspectives,” E.E. Polli and M. Cortellaro, eds., Hans Huber, Bern (1983).

    Google Scholar 

  14. L.A. Cobb, R.S. Baum, H. Alvarez III, and W.A. Schaffer, Resuscitation from out-of-hospital ventricular fibrillation: 4 years follow-up, Circulation, 52(Suppl. III): 111–223 (1975).

    Google Scholar 

  15. M.A. De Wood, J. Spores, and R. Notske, Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction, N. Engl. J. Med., 303: 897–902 (1980).

    Article  Google Scholar 

  16. R.L. Ridolfi and G.M. Hutchinson, The relationship between coronary artery lesions and myocardial infarcts: ulceration of atherosclerotic plaques precipitating coronary thrombosis, Am. Heart J., 93: 468–486 (1977).

    Article  Google Scholar 

  17. Anturane Reinfarction Trial Research Group, Sulfinpyrazone in the prevention of sudden death after myocardial infarction, N. Engl. J. Med., 302: 250–256 (1980).

    Article  Google Scholar 

  18. Anturan Reinfarction Italian Study, Sulfinpyrazone in post-myocardial infarction, Lancet, i: 237–242 (1982).

    Google Scholar 

  19. The FDA’s critique of the Anturane Reinfarction Trial, N. Engl. J. Med., 303: 1488–1492 (1980).

    Google Scholar 

  20. P.C. Elwood, A.L. Cochrane, and M.L. Burr, A randomized controlled trial of acetylsalicyclic acid in the secondary prevention of mortality from myocardial infarction, Br. Med. J., 1: 436 (1974).

    Article  Google Scholar 

  21. P.C. Elwood and P.M. Sweetman, Aspirin and secondary mortality after myocardial infarction, Lancet, ii: 1313 (1979).

    Article  Google Scholar 

  22. Coronary Drug Project Research Group, Aspirin in coronary heart disease, J. Clin. Dis., 29: 625 (1976).

    Google Scholar 

  23. K. Breddin, German-Austrian multicentre prospective study on the prevention of secondary myocardial infarction by aspirin in comparison to phenprocoumon and placebo, Thromb. Haemost., 38: 168 (1977).

    Google Scholar 

  24. Aspirin Myocardial Infarction Study Research Group, A randomized controlled trial of aspirin in persons recovered from myocardial infarction, J.A.M.A., 243: 661 (1980).

    Article  Google Scholar 

  25. Persantine-Aspirin Re-Infarction Study Research Group, Persantine and aspirin in coronary heart disease, Circulation, 62: 449 (1980).

    Article  Google Scholar 

  26. The E.P.S.I.M. Research Group, A controlled comparison of aspirin and oral anticoagulants in prevention of death, after myocardial infarction, N. Engl. J. Med., 307: 701–708 (1982).

    Article  Google Scholar 

  27. M. Moser, W. Plains, and R. Goslin, ß-blockers and myocardial infarction, Arch. Intern. Med., 142: 1618 (1982).

    Article  Google Scholar 

  28. W.B. Campbell, A.R. Johnson, K.S. Callahan, and R.M. Graham, Anti-platelet activity of beta-adrenergic antagonists: inhibition of thromboxane synthesis and platelet aggregation in patients receiving long-term propanolol treatment, Lancet, ii: 1382 (1981).

    Article  Google Scholar 

  29. K.W. Hansen, R. Klysner, A. Geisler, J.B. Knudsen, S. Glarer, and J. Gormsen, Platelet aggregation and beta-blockers, Lancet, i: 224 (1982).

    Article  Google Scholar 

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© 1985 Plenum Press, New York

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Polli, E.E., Cortellaro, M. (1985). Critical Review of Myocardial Infarction Prevention with Antiaggregants. In: Cajozzo, A., Perricone, R., Di Marco, P., Palazzolo, P. (eds) Advances in Hemostasis and Thrombosis. Ettore Majorana International Science Series, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9424-6_18

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  • DOI: https://doi.org/10.1007/978-1-4615-9424-6_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9426-0

  • Online ISBN: 978-1-4615-9424-6

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