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Evidence for the Activation of 3-Methylcholanthrene as a Carcinogen in vivo and as a Mutagen in vitro by P1-450 from Inbred Strains of Mice

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Cytochromes P-450 and b5

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 58))

Summary

Genetic differences in aromatic hydrocarbon “responsiveness” exist among various mouse strains. New formation of cytochrome P1–450 and the induction of aryl hydrocarbon (benzo [a]pyrene) hydroxylase (as well as numerous other monooxygenase activities) appear to be associated ultimately with genes that cosegregate at a small number of genetic loci. By comparing “responsive” and “nonresponsive” siblings, we can evaluate the susceptibility of each individual to various mutagenic chemicals in vitro or carcinogenic agents in vivo.

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Author information

Authors and Affiliations

  1. Section on Developmental Pharmacology, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20014, USA

    Daniel W. Nebert & James S. Felton

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  1. Daniel W. Nebert
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  2. James S. Felton
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Editors and Affiliations

  1. Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

    David Y. Cooper  & Otto Rosenthal  & 

  2. Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Robert Snyder  & Charlotte Witmer  & 

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© 1975 Plenum Press, New York

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Nebert, D.W., Felton, J.S. (1975). Evidence for the Activation of 3-Methylcholanthrene as a Carcinogen in vivo and as a Mutagen in vitro by P1-450 from Inbred Strains of Mice. In: Cooper, D.Y., Rosenthal, O., Snyder, R., Witmer, C. (eds) Cytochromes P-450 and b5 . Advances in Experimental Medicine and Biology, vol 58. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9026-2_9

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  • DOI: https://doi.org/10.1007/978-1-4615-9026-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9028-6

  • Online ISBN: 978-1-4615-9026-2

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