Abstract
It has been known for almost a decade that catecholamines depress hepatic drug metabolism (Kato and Gillette, 1965). The action of these hormones is mediated by cyclic adenosine -3’, 5’- monophosphate (cAMP) and the cAMP level in the liver becomes elevated after hormone administration (Exton et al., 1971). However, there is relatively little information available concerning the direct involvement of cAMP in hepatic drug metabolism. Weiner et al., (1972a) have recently shown that cAMP, or rather its dibutyryl derivative, N6, O2’-dibutyryl cAMP (DBcAMP), increases sleeping time after hexobarbital administration. Subsequently it was demonstrated that DBcAMP treatment decreases the activities of hepatic aniline hydroxylase and aminopyrine demethylase and the concentration of cytochrome P-450 (Ross et al., 1973) and partially inhibits the induction of cytochrome P-450 stimulated by phenobarbital (Dressler et al., 1973).
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Hutterer, F., Dressler, K., Greim, H., Czygan, P., Schaffner, F., Popper, H. (1975). Effect of Cyclic Amp on the Phenobarbital Induced Increase in Cytochrome P-450 and Hypertrophy of the Endoplasmic Reticulum of the Rat Liver. In: Cooper, D.Y., Rosenthal, O., Snyder, R., Witmer, C. (eds) Cytochromes P-450 and b5 . Advances in Experimental Medicine and Biology, vol 58. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9026-2_8
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DOI: https://doi.org/10.1007/978-1-4615-9026-2_8
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