Skip to main content
SpringerLink
Log in

Liberation of Vasoactive Materials from Mast Cells in Anaphylactic Shock

  • Chapter
The Fundamental Mechanisms of Shock

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 23))

Abstract

Anaphylactic shock is a sudden and often fatal syndrome that can occur when antigen combines with antibodies in a sensitized individual. The reaction involves at least two steps, i.e. fixation of bivalent immunoglobulin and activation of processes leading to release of vasoactive mediators from the cell. The effects of this acute allergic reaction include hypotension, hypovolemia, bronchoconstriction, increased capillary permeability, and stasis and hemorrhage in visceral vascular beds. The actions of various mediators, and thus the prominence of these manifestations of shock, vary from one animal species to another. For example, in dogs, the more pronounced effects of anaphylactic shock are hypotension, portal venous constriction, and hemorrhage of the gastrointestinal tract. In guinea pigs, bronchoconstriction is most prominent, and anaphylaxis in man may be manifest by a combination of urticaria, hypotension, and bronchoconstriction.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Åborg, C.H., J. Novotny, and V. Uvnäs. Ionic binding of histamine in mast cell granules. Acta physiol. scand. 69: 276–283, 1967.

    Article  PubMed  Google Scholar 

  2. Adams-Ray, J., A. Dahlstrom, and C. Sachs. Uptake of 3,4-dihydroxyphenylalanine and 5-hydroxytryptophan by catechola- mine-forming mast cells in the hamster. Acta physiol. scand. 67: 295–299, 1966.

    Article  PubMed  CAS  Google Scholar 

  3. Änggärd, E., B. Bergqvist, B. Högberg, K. Johansson, I.L. Thon, and B. Uvnäs. Biologically active principles occurring in histamine release from cat paw, guinea pig lung, and isolated rat mast cells. Acta physiol. scand. 59: 97–110, 1963.

    Article  PubMed  Google Scholar 

  4. Archer, G.T. Release of heparin from the mast cells of the rat. Nature (London) 191: 90, 1961.

    Article  CAS  Google Scholar 

  5. Archer, G.T., and M. Jackas. Disruption of mast cells by a component of eosinophil granules. Nature (London) 205: 599–600, 1965.

    Article  CAS  Google Scholar 

  6. Assem, E.S.K., and H.O. Schild. Inhibition by sympathomimetic amines of histamine release by antigen in passively sensitized human lung. Nature (London) 224: 1028–1029, 1969.

    Article  CAS  Google Scholar 

  7. Austen, K.F., and Bloch, K.J. Differentiation in vitro of antigen-induced histamine release from complement-dependent immune injury. In Boston: Ciba Foundation Symposium on Complement, edited by G.W. Wolstenholme and J. Knight. Little, Brown & Co., 1965.

    Google Scholar 

  8. Becker, E.L., and K.F. Austen. A comparison of the specificity of inhibition by phosphonate esters of the first component of complement and the antigen-induced release of histamine from guinea pig lufig. J. Exptl. Med. 120: 491–506, 1964.

    Article  CAS  Google Scholar 

  9. Becker, E.L., and Austen, K.F. Mechanisms of immunologic injury of rat peritoneal mast cells. I. The effect of phosphonate inhibitors on the homocytotropic antibody-mediated histamine release and the first component of rat complement. J. Exptl. Med. 124: 379–395, 1966.

    Article  CAS  Google Scholar 

  10. Benditt, E.P., R.L. Wong, M. Arase, and E. Roeper. 5-Hydroxytryptamine in mast cells. Proc. Soc. Exptl. Biol. Med. 90: 303–304, 1955.

    CAS  Google Scholar 

  11. Benditt, E.P., and M. Arase. An enzyme in mast cells with properties like chymotrypsin. J. Exptl. Med. 110: 451–460, 1959.

    Article  CAS  Google Scholar 

  12. Bloom, G.D., and N. Chakravarty. Time course of anaphylactic histamine release and morphological changes in rat peritoneal mast cells. Acta physiol. scand. 78: 410–419, 1970.

    Article  PubMed  CAS  Google Scholar 

  13. Chakravarty, N. The mechanism of histamine release in anaphylactic reaction in guinea pig and rat. Acta physiol. scand. 48: 146–166, 1960.

    Article  PubMed  CAS  Google Scholar 

  14. Cochrane, C.G., and H.J. Muller-Eberdard. The derivation of two distinct anaphylatoxin activities from the third and fifth components of human complement. J. Exptl. Med. 127: 371–385, 1968.

    Article  CAS  Google Scholar 

  15. Dale, H.H., and P.P. Laidlaw. Histamine shock. J. Physiol. 52: 355–390, 1918–19.

    Google Scholar 

  16. Diamant, B., and P.G. Kruger. Histamine release from isolated rat- peritoneal mast cells induced by adenosine 5-triphosphate. Acta physiol. scand. 71: 291–302, 1967.

    Article  PubMed  CAS  Google Scholar 

  17. Diamant, B., and P.G. Kruger. Structural changes of isolated rat peritoneal mast cells induced by adenosine triphosphate and adenosine diphosphate. J. Histochem. Cytochem. 16: 707–716, 1968.

    Article  PubMed  CAS  Google Scholar 

  18. Dias da Silva, W., and I.H. Lepow. Complement as a mediator of inflammation. II. Biological properties of anaphylatoxin prepared with purified components of human complement. J. Exptl. Med. 125: 921–946, 1967.

    Article  CAS  Google Scholar 

  19. Douglas, W.W. Stimulus secretion coupling: The concept and clues from chromaffin and other cells. Brit. J. Pharmacol. 34: 451–474, 1968.

    CAS  Google Scholar 

  20. Falk, B., T. Nystedt, E. Rosengren, and J. Stenflo. Dopamine and mast cells in ruminants. Acta pharmacol. toxicol. 21: 51–58, 1964.

    Article  Google Scholar 

  21. Fawcett, D.W. Physiologically significant specializations of the cell surface. Circulation 26: 1105–1126, 1962.

    PubMed  CAS  Google Scholar 

  22. Garcia-Arocha, H. Release of histamine and 5-hydroxytryptamine from cells of the peritoneal fluid of rats. Can. J. Biochem. Physiol. 39: 395–403, 1961.

    Article  PubMed  CAS  Google Scholar 

  23. Garcia-Arocha, H. Liberation of 5-hydroxytryptamine and histamine in the anaphylactic reaction of the rat. Can. J. Biochem. Physiol. 39: 403–416, 1961.

    Article  PubMed  CAS  Google Scholar 

  24. Giacobini, E., G. Sedvall, and B. Uvnls. Phosphatidase A activity of isolated rat mast cells and of red blood cells, white blood cells, and spinal ganglion cells. Exptl. Cell Res. 37: 368–375, 1965.

    Article  PubMed  CAS  Google Scholar 

  25. Gillespie, E., R.J. Levine, and S.E. Malawista. Histamine release from rat peritoneal mast cells: Inhibition by colchicine and potentiation by deuterium oxide. J. Pharmacol. Exptl. Therap. 164: 158–165, 1968.

    CAS  Google Scholar 

  26. Goth, A. Effect of drugs on mast cells. Advan. Pharmacol. 5: 47–78, 1967.

    Article  CAS  Google Scholar 

  27. Hogberg, B., and B. Uvnäs. Further observations on the disruption of rat mesentery mast cells caused by compound 48/80, antigen-antibody reaction, lecithinase A, and decylamine. Acta physiol. scand. 48: 133–145, 1960.

    Article  PubMed  CAS  Google Scholar 

  28. Ishizaka, K. Human reaginic antibodies. Ann. Rev. Med. 21: 187–200, 1970.

    Article  CAS  Google Scholar 

  29. Ishizaka, T., K. Ishizaka, R.P. Orange, and K.F. Austen. The capacity of human immunoglobulin E to mediate the release of histamine and slow-reacting substance of anaphylaxis from monkey lung. J. Immunol. 104: 335–343, 1970.

    CAS  Google Scholar 

  30. Ishizaka, T., K. Ishizaka, R.P. Orange, and K.F. Austen. Pharmacologic inhibition of the antigen-induced release of histamine and slow-reacting substance of anaphylaxis (SRS-A) from monkey lung tissues mediated by human IgE. J. Immunol. 106: 1267–1273, 1971.

    PubMed  CAS  Google Scholar 

  31. Janoff, A., S. Schaefer, J. Scherer, and M. Bean. Mediators of inflammation in leukocyte lysosomes. II. Mechanisms of action of lysosomal cationic protein upon vascular permeability in the rat. J. Exptl. Med. 122: 841–851, 1965.

    Article  CAS  Google Scholar 

  32. Johnson, A.R., and N.C. Moran. The selective release of histamine from rat mast cells by compound 48/80 and antigen. Am. J. Physiol. 216: 453–459, 1969.

    PubMed  CAS  Google Scholar 

  33. Johnson, A.R., and N.C. Moran. Inhibition of the release of histamine from rat mast cells: The effect of cold and adrenergic drugs on release of histamine by compound 48/80 and antigen. J. Pharmacol. Exptl. Therap. 175: 632–640, 1970.

    CAS  Google Scholar 

  34. Katayama, Y., J.V. Auditore, and N. Ende. Purification and characterization of a mouse mast cell esteroprotease. Exptl. Mol. Pathol. 14: 228–242, 1971.

    Article  CAS  Google Scholar 

  35. Lagunoff, D. Structural aspects of histamine binding: The mast cell granule. In: Mechanisms of Release of Biogenic Amines, edited by U.S. Von Euler, S. Rosell, and B. Uvnas. New York: Pergammon Press, 1966, pp. 79–94.

    Google Scholar 

  36. Lagunoff, D. The properties of mast cell proteases. Biochem. Pharmacol. (Suppl.) 17: 221–227, 1968.

    Article  Google Scholar 

  37. Levy, D.A., and J.A. Carlton. Influence of temperature on the inhibition by colchicine of allergic histamine release. Proc. Soc. Exptl. Biol. Med. 130: 1333–1336, 1969.

    CAS  Google Scholar 

  38. Lichtenstein, L.M., and S. Margolis. Histamine release in vitro: Inhibition by catecholamines and methylxanthines. Science 161: 902–904, 1968.

    Article  PubMed  CAS  Google Scholar 

  39. Lichtenstein, L.M., and A.G. Osier. Studies on the mechanisms of hypersensitivity phenomena. IX. Histamine release from human leukocytes by ragweed pollen antigen. J. Exptl. Med. 120: 507–530, 1964.

    Article  CAS  Google Scholar 

  40. Mongar, J. L., and H.O. Schild. Cellular mechanisms in anaphylaxis. Physiol. Rev. 42: 226–270, 1962.

    PubMed  CAS  Google Scholar 

  41. Moran, N.C., B. Uvnas, and B. Westerholmu Release of 5-hydroxytryptamine and histamine from rat mast cells. Acta physiol. scand. 56: 26–41, 1962.

    Article  CAS  Google Scholar 

  42. Mota, I. The mechanism of anaphylaxis. I. Production and biological properties of “mast cell sensitizing” antibody. Immunology 7: 681–699, 1964.

    PubMed  CAS  Google Scholar 

  43. Mota, I., and W. Dias da Silva. Antigen-induced damage to isolated sensitized mast cells. Nature (London) 186: 245–246, 1960.

    Article  CAS  Google Scholar 

  44. Mota, I., and T. Ishii. Inhibition of mast cell disruption and histamine release in rat anaphylaxis in vitro: Comparison with compound 48/80. Brit. J. Pharmacol. 15: 82–87, 1960.

    PubMed  CAS  Google Scholar 

  45. Orange, R.P., and K.F. Austen. Slow-reacting substances of anaphylaxis. Advan. Immunol. 10: 106–145, 1969.

    Google Scholar 

  46. Orange, R.P., D.J. Stechschulte, and K.F. Austen. Immunochemical and biologic properties of rat IgE. II. Capacity to mediate the immunologic release of histamine and slow- reacting substance of anaphylaxis (SRS-A). J. Immunol. 105: 1087–1095, 1970.

    PubMed  CAS  Google Scholar 

  47. Orange, R.P., G.W. Austen, and K.F. Austen. Immunological release of histamine and slow-reacting substance of anaphylaxis from human lung. I. Modulation by agents influencing cellular levels of cyclic 3′5′-adenosine monphosphate. J. Exptl. Med. 134: 136s–148s, 1971.

    CAS  Google Scholar 

  48. Paton, W.D.M. Compound 48/80: A potent histamine liberator Brit. J. Pharmacol. 6: 499–508, 1951.

    CAS  Google Scholar 

  49. Patterson, R., and Sparks, D.B. The passive transfer to normal dogs of skin reactivity, asthma and anaphylaxis from a dog with spontaneous ragweed pollen hypersensitivity. J. Immunol. 88: 262–268, 1962.

    PubMed  CAS  Google Scholar 

  50. Perera, B.A.V., and J.L. Mongar. The role in anaphylaxis of a chymotrypsin-like enzyme in rat mast cells. Immunology 6: 478–483, 1963.

    PubMed  CAS  Google Scholar 

  51. Ranadive, N.S., and C.G. Cochrane, Mechanisms of histamine release from mast cells by cationic protein (band 2) from neutrophil lysosomes. J. Immunol. 106: 506–516, 1971.

    PubMed  CAS  Google Scholar 

  52. Riley, J.F. The Mast Cells. Edinburgh and London: E. & S. Livingstone, 1959.

    Google Scholar 

  53. Rothschild, A.M. Histamine release by basic compounds. In: Handbook of Experimental Pharmacology, edited by O. Eichler and A. Farar, vol. 18; Histamine and Antihistamines3 edited by M. Rocha e Silva, New York: Springer-Verlag, 1966, Part 1, pp. 386–430.

    Google Scholar 

  54. Scroggie, A.E., and L.B. Jaques. The release of histamine and heparin by antigen from the isolated perfused liver of the sensitized dog. J. Immunol. 62: 103–116, 1949.

    PubMed  CAS  Google Scholar 

  55. Slorach, S.A., and B. Uvnas. Dissociation of histamine release and Na uptake in rat mast cells exposed to compound 48/80 in vitro. Acta physiol. scand. 76: 201–212, 1969.

    Article  PubMed  CAS  Google Scholar 

  56. Tasaka, K., K. Sugiyama, S. Komoto, and H. Yamasaki. Dissociation of degranulation and depolarization of the rat mesentery mast cell exposed to compound 48/80 and ATP. Proc. Japan Acad. 46: 826–830, 1970.

    CAS  Google Scholar 

  57. Thon, I.L., and B. Uvnas. Degranulation and histamine release: Two consecutive steps in the response of rat mast cells to compound 48/80. Acta physiol. scand. 71: 303–315, 1967.

    Article  PubMed  CAS  Google Scholar 

  58. Uvnäs, B. Release processes in mast cells and their activation by injury. Ann. N.Y. Acad. Sci. 116: 880–890, 1964.

    Google Scholar 

  59. Uvnäs, B., and J. Antonsson. Triggering action of phosphotidase A and chymotrypsins on degranulation of rat mesentery mast cells. Biochem. Pharmacol. 12: 867–873, 1963.

    Article  Google Scholar 

  60. Uvnäs, B., and I.L. Thon. Evidence for enzymatic histamine release from isolated rat mast cells. Exptl. Cell Res. 23: 45–57, 1961.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Emory University, Atlanta, Georgia, USA

    Alice R. Johnson Ph.D.

Authors
  1. Alice R. Johnson Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Veterans Administration Hospital Departments of Physiology-Biophysics and Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Lerner B. Hinshaw Ph.D.

  2. Learning Resources Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Barbara G. Cox (Editorial Consultant) (Editorial Consultant)

Rights and permissions

Reprints and permissions

Copyright information

© 1972 Plenum Press, New York

About this chapter

Cite this chapter

Johnson, A.R. (1972). Liberation of Vasoactive Materials from Mast Cells in Anaphylactic Shock. In: Hinshaw, L.B., Cox, B.G. (eds) The Fundamental Mechanisms of Shock. Advances in Experimental Medicine and Biology, vol 23. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9014-9_34

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9014-9_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9016-3

  • Online ISBN: 978-1-4615-9014-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation