Abstract
The possibility that residues of pesticides present in food eaten by man could lead to an increased risk that the consumer might develop cancer has been considered twice in the preceding twelve volumes of Residue Reviews. OSER (1962) discussed the experimental studies that are made or should be made in experimental animals in order to provide evidence as to whether or not the substance under investigation had a carcinogenic action on these animals. He emphasized the lack of agreement on the best experimental methods to be employed and pointed out the difficulties of interpreting the findings in animal experiments in such a way that would enable anyone to indicate the hazard the substance under test might present to man if present in his food. durham (1963) in a very comprehensive review of the health hazards that might arise from pesticide residues present in food discussed the difficulties of obtaining any information on the effects on man. He also considered in some detail the problems raised by residues of Aramite [2 - (p-tertiarybutylphenoxy) -isopropyl-2-chloroethyl sulphite], aminotriazole, dichlorodiphenyl-dichloroethane (DDT), and dieldrin.
Ideally the slightest real suspicion of carcinogenicity ought to be enough to prevent a substance from being allowed in the human environment whereas the most rigid proof ought to be insisted upon when the result is to be used as evidence upon which to base further work or to support a theory of carcinogenesis. In practice the reverse is true. (from clayson 1962)
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References
Barnes, J. M., and W. H. Butler: Carcinogenic activity of aflatoxin to rats. Nature 202, 1016 (1964).
Barnes, J. M., P. N. Magee, E. Boyland, A. Haddow, R. D. Passey, W. S. Bullough, C. N. D. Cruickshank, M. H. Salaman, and R. T. Williams: The non-toxicity of maleic hydrazide for mammalian tissues. Nature 180, 62 (1957).
Clayson, D. B.: Chemical carcinogenesis, p. 55. London: Churchill 1962. crain, R. c.: Spontaneous tumours in wistar rats. Amer. j. Pathol. 34, 311 (1958).
Davis, K. J., and O. G. Fitzhugh: Tumorogenicity of aldrin and dieldrin. Toxicol. Applied Pharmacol. 4, 187 (1962).
Deichmann, W. B., T. Scotti, J. Radomski, E. Bernal, M. Coplan, and F. Woods: Synergism among oral carcinogens. ii. Results of the simultaneous feeding of bladder carcinogens to dogs. Toxicol. Applied Pharmacol. 7, 657 (1965).
Dickens, F., and H. E. H. Jones: Further studies on the carcinogenic action of certain lactones and related substances in the rat and mouse. Brit. j. Cancer 19, 392 (1965).
Doll, R., and A. Bradford Hill: Human lung cancer and smoking. Brit. Med. J. I, 1399 and 1460 (1964).
Druckrey, H.: Konstitution und Wirkung cancerogener Substanzen. Arzneimit. Forsch. 1, 383 (1952).
Druckrey, H., and D. Schmahl: Quantitative Analyse der experimentellen Krebserzengung. Naturwiss. 49, 217 (1962).
Durham, W. F.: Pesticide residues in foods in relation to human health. Residue Reviews 4, 33 (1963).
Falk, H. L., Sandra J. Thompson, and P. Kohn: The carcinogenic potential of pesticides. Arch. Environmental Health 10, 847 (1965).
Fitzhugh, O. G., and A. A. Nelson: Chronic oral toxicity of DDT. J. Pharmacol. 89, 18 (1947).
Fitzhugh, O. G., and A. A. Nelson: Tumours in rats fed thiourea and thioacetamide. Science 108, 626 (1948).
Fitzhugh, O. G., A. A. Nelson, and M. L. Quaife: Chronic oral toxicity of aldrin and dieldrin in rats and dogs. Food Cosmetic Toxicol. 2, 551 (1964).
Glinos, A. D., N. L. R. Bucher, and J. C. Aub: I. The effect of liver regeneration on tumour formation in rats fed 4-dimethylaminoazobenzene. J. Expt. Med. 93, 313 (1951).
Jukes, T. H., and C. B. Shaffer: Antithyroid effects of aminotriazole. Science 132, 296 (1960).
Macdonald, J. C., E. C. Miller, J. A. Miller, and H. P. Rusch: Synergistic action of mixtures of certain hepatic carcinogens. Cancer Research 12, 50 (1952).
Magee, P. N.: Biochemical and pathological mechanism in experimental liver cancer. Scient. Basis of Med. Ann. Reviews, p. 172. London: Athlone Press 1962.
Magee, P. N., and J. M. Barnes: Carcinogenic activity of nitroso compounds. Ann. Review of Cancer (to be published).
Magee, P. N., and J. M. Barnes: The production of malignant primary hepatic tumours in the rat by feeding dimethylnitrosamine. Brit. J. Expt. Cancer 10, 114 (1956).
Miller, E. C., J. A. Miller, R. R. Brown, and J. C. Macdonald: On the protective action of certain polycyclic aromatic hydrocarbons against carcinogenesis by aminoazo dyes and 2-acetylaminofluorene. Cancer Research 18, 469 (1958).
Napalkov, N. P.: On blastomagenic effect of antithyroid drugs. Union International e Contre le Cancer Symposium, Paris (1965).
Oser, B. L.: The experimental induction of cancer by pesticide residues and food additives: its rationale and interpretation. Residue Reviews 1, 1 (1962).
Oser, B. L., and M. Oser: 2-(p-ter/-Butylphenoxy) isopropyl-2-chloroethyl sulphite (Aramite). II. Carcinogenicity. Toxicol. Applied Pharmacol. 4, 70 (1962).
Popper, H., S. S. Sternberg, B. L. Oser, and M. Oser: The carcinogenic affect of Aramite in rats. A study of hepatic nodules. Cancer 13, 1035 (I960).
Purves, H. D., and W. E. Griesbach: Studies on experimental goitre. VIII. Thyroid tumours in rats treated with thiourea. Brit. J. Expt. Pathol. 28, 46 (1947).
Radomski, J. L., W. B. Deichmann, W. E. Macdonald, and E. M. Glass: Synergism among oral carcinogens. I. Results of the simultaneous feeding of four tumorigens to rats. Toxicol. Applied Pharmacol. 7, 652 (1965).
Schoental, R.: Liver lesions in young rats suckled by mothers treated with pyrrolidine alkaloids. J. Pathol. Bact. 77, 485 (1959).
Sternberg, S. S., H. Popper, B. L. Oser, and M. Oser: Gall bladder and bile duct adenocarcinoma in dogs after long term feeding of Aramite. Cancer 13, 780 (1960).
Wilson, R. H., F. Deeds, and A. J. Cox: The carcinogenic activity of 2-acetamino-fluorene. II. Effects of concentration and of duration of exposure. Cancer Research 7, 444 (1947).
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Barnes, J.M. (1966). Carcinogenic hazards from pesticide residues. In: Gunther, F.A. (eds) Residue Reviews. Reviews of Environmental Contamination and Toxicology, vol 13. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-8407-0_3
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