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Metabolic Inhibitors Affect the Conductance of Low Voltage-Activated Calcium Channels in Brain Capillary Endothelial Cells

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Frontiers in Arterial Chemoreception

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 410))

Abstract

The brain capillary endothelium plays an essential role in the preservation of the blood-brain barrier and in the control of blood microcirculation. Since hypoxia (Po2: 20 Torr) increases K+ conductance in brain capillary endothelial cells (BCECs) (Delpiano, 1994), the question arises whether chemical agents that impair cell metabolism may produce similar changes in Ca2+ conductance. To better understand the signal transduction mechanism that operates on BCECs during hypoxia and which may be of physiological relevance for the control of brain blood flow microcirculation, these cells were investigated in voltage-clamp experiments using the perforated nystatin patch-clamp technique (Horn & Marty, 1988).

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Author information

Authors and Affiliations

  1. Max-Planck-Institut für Molekulare Physiology, Dortmund, Germany

    M. A. Delpiano

Authors
  1. M. A. Delpiano
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Editor information

Editors and Affiliations

  1. Catholic University of Chile, Santiago, Chile

    Patricio Zapata

  2. University of Utah School of Medicine, Salt Lake City, Utah, USA

    Carlos Eyzaguirre

  3. University of Oxford, Oxford, England

    Robert W. Torrance

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© 1996 Springer Science+Business Media New York

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Delpiano, M.A. (1996). Metabolic Inhibitors Affect the Conductance of Low Voltage-Activated Calcium Channels in Brain Capillary Endothelial Cells. In: Zapata, P., Eyzaguirre, C., Torrance, R.W. (eds) Frontiers in Arterial Chemoreception. Advances in Experimental Medicine and Biology, vol 410. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5891-0_16

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  • DOI: https://doi.org/10.1007/978-1-4615-5891-0_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7702-3

  • Online ISBN: 978-1-4615-5891-0

  • eBook Packages: Springer Book Archive

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