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Is Cytochrome P-450 Involved in Hypoxic Inhibition of K+ Currents in Rat Type I Carotid Body Cells?

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Frontiers in Arterial Chemoreception

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 410))

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Abstract

Patch-clamp studies of isolated type I carotid body cells have revealed that hypoxia inhibits K+ channels (reviewed in Peers & Buckler, 1995). In cells isolated from young (ca. 10 days old) rats, hypoxia predominantly inhibits high conductance Ca2+-activated K+ (KCa) channels (Peers, 1990; Wyatt & Peers, 1995), an effect which leads to cell depolarization sufficient to open voltage-gated Ca2+ channels (Wyatt & Peers, 1995) and hence trigger Ca2+ influx (Buckler & Vaughan-Jones, 1994), which is necessary for initiation of transmitter release. Hypoxic inhibition of KCa channels is not a membrane-delimited effect, but requires undefined cytosolic factors (Wyatt & Peers, 1995).

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References

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Authors and Affiliations

  1. Institute for Cardiovascular Research, Leeds University, Leeds, LS2 9JT, UK

    Christopher J. Hatton & Chris Peers

Authors
  1. Christopher J. Hatton
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  2. Chris Peers
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Editor information

Editors and Affiliations

  1. Catholic University of Chile, Santiago, Chile

    Patricio Zapata

  2. University of Utah School of Medicine, Salt Lake City, Utah, USA

    Carlos Eyzaguirre

  3. University of Oxford, Oxford, England

    Robert W. Torrance

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© 1996 Springer Science+Business Media New York

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Hatton, C.J., Peers, C. (1996). Is Cytochrome P-450 Involved in Hypoxic Inhibition of K+ Currents in Rat Type I Carotid Body Cells?. In: Zapata, P., Eyzaguirre, C., Torrance, R.W. (eds) Frontiers in Arterial Chemoreception. Advances in Experimental Medicine and Biology, vol 410. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5891-0_12

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  • DOI: https://doi.org/10.1007/978-1-4615-5891-0_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7702-3

  • Online ISBN: 978-1-4615-5891-0

  • eBook Packages: Springer Book Archive

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