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Effect of Perfluorochemical Emulsion on Hemorheology and Shear Induced Blood Trauma

Possible Mechanisms and Future Applications

  • Chapter
Oxygen Transport to Tissue XVIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 411))

Abstract

Blood trauma has been recognized as one of the key problems associated with assisted circulation. Indeed, the main requirement for improved heart-assist devices is the reduction of blood cell damage. The extremely high shear forces and prolonged contact between blood and foreign surfaces can cause mechanical destruction of erythrocytes (hemolysis), activation of platelets, changes in mechanical properties of erythrocytes1 and thus reduction of oxygen delivery. Even low level of hemolysis, in turn, drastically increases RBC aggregation at low shear conditions2. Additionally, plasma free hemoglobin can have a toxic effect on the cardiovascular system, probably because of hemoglobin vasoactivity, mediated by its property to bind nitric oxide (NO), an endothelium-derived relaxing factor3. Alternatively, NO might be destroyed by O2 radicals formed in the presence of hemoglobin3.

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Author information

Authors and Affiliations

  1. Artificial Heart and Lung Center, Center for Biotechnology and Bioengineering, University of Pittsburgh, 300 Technology Drive, Pittsburgh, Pennsylvania, 15219, USA

    M. V. Kameneva, H. S. Borovetz, J. F. Antaki, P. Litwak, W. J. Federspiel, R. L. Kormos & B. P. Griffith

Authors
  1. M. V. Kameneva
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  2. H. S. Borovetz
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  3. J. F. Antaki
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  4. P. Litwak
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  5. W. J. Federspiel
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  6. R. L. Kormos
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  7. B. P. Griffith
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Editor information

Editors and Affiliations

  1. University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Edwin M. Nemoto

  2. Case Western Reserve University, Cleveland, Ohio, USA

    Joseph C. LaManna

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© 1997 Springer Science+Business Media New York

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Kameneva, M.V. et al. (1997). Effect of Perfluorochemical Emulsion on Hemorheology and Shear Induced Blood Trauma. In: Nemoto, E.M., et al. Oxygen Transport to Tissue XVIII. Advances in Experimental Medicine and Biology, vol 411. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5865-1_49

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  • DOI: https://doi.org/10.1007/978-1-4615-5865-1_49

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7689-7

  • Online ISBN: 978-1-4615-5865-1

  • eBook Packages: Springer Book Archive

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