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New Horizons in Allergy Immunotherapy pp 309–316Cite as

In vivo Direction of CD4 T Cells to TH1 and TH2-Like Patterns of Cytokine Synthesis

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 409))

Summary

Factors that influence the initial development, and continued maintenance, of Thl or Th2-like responses in vivo play a pivotal role in determining immune effector mechanisms and clinical outcome. Here, we review recent developments in this area with particular emphasis on (i) the ability of chemically modified exogenous antigens to preferentially activate Thl-dominated responses in vivo and (ii) the role played by NK cells in initial commitment of naive exogenous antigen-specific T cells to Thl or Th2-like cytokine synthesis. We find that NK cell depletion of naive mice prior to immunization with OVA (which induces balanced Th0 like responses), or a high Mr polymer (that preferentially elicits OVA-specific Thl-dominated responses), fails to influence the development of cytokine or specific antibody responses. The results argue that NK cells do not play an essential role in shaping induction of immune responses to exogenous antigens, the most common class of inhalant allergen.

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Author information

Author notes

  1. Randall S. Gieni

    Present address: Department of Pediatrics, Stanford University, Stanford, California, USA

Authors and Affiliations

  1. Department of Immunology, University of Manitoba, Winnipeg, Canada, R3E 0W3

    Kent T. HayGlass, Mingdong Wang & Randall S. Gieni

  2. Department of Pathology, University of Manitoba, Winnipeg, Canada, R3E 0W3

    Cynthia Ellison & John Gartner

Authors
  1. Kent T. HayGlass
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  2. Mingdong Wang
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  3. Randall S. Gieni
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  4. Cynthia Ellison
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  5. John Gartner
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Editor information

Editors and Affiliations

  1. University of Manitoba, Winnipeg, Manitoba, Canada

    Alec Sehon  & Kent T. HayGlass  & 

  2. Institute of General and Experimental Pathology, Vienna, Austria

    Dietrich Kraft

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© 1996 Springer Science+Business Media New York

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HayGlass, K.T., Wang, M., Gieni, R.S., Ellison, C., Gartner, J. (1996). In vivo Direction of CD4 T Cells to TH1 and TH2-Like Patterns of Cytokine Synthesis. In: Sehon, A., HayGlass, K.T., Kraft, D. (eds) New Horizons in Allergy Immunotherapy. Advances in Experimental Medicine and Biology, vol 409. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5855-2_44

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  • DOI: https://doi.org/10.1007/978-1-4615-5855-2_44

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7684-2

  • Online ISBN: 978-1-4615-5855-2

  • eBook Packages: Springer Book Archive

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