Abstract
The role of the cockroach as an etiologic agent of respiratory allergic disorders is well documented (1–3). Positive skin test reactivity to whole body cockroach extracts is second only to the house dust mite of the indoor allergens; however, the identification of clinically relevant antigens and an understanding of the immunobiology of cockroach-induced asthmatic reactions is just beginning (4). The prevalence of asthma induced by cockroach exposure has been coupled with the identification of major cockroach allergens ranging in molecular weight from 6,000 to 100,000 daltons (5–10). In earlier experiments, we documented the in vitro translation of RNA from German cockroaches for the presence of IgE-binding proteins (11). In this report, we describe the isolation of a cDNA clone from a cDNA library derived from the German cockroach (Blattella germanica) encoding a major allergen, Bla g 90 kD.
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Helm, R.M., Cockrell, G., Stanley, J.S., Brenner, R., Burks, A.W., Bannon, G.A. (1996). A Major Allergen Involved in IgE Mediated Cockroach Hypersensitivity is a 90 kD Protein with Multiple IgE Binding Domains. In: Sehon, A., HayGlass, K.T., Kraft, D. (eds) New Horizons in Allergy Immunotherapy. Advances in Experimental Medicine and Biology, vol 409. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5855-2_38
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DOI: https://doi.org/10.1007/978-1-4615-5855-2_38
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