Abstract
The concept that specific immune responsiveness is genetically controlled was in itially developed studying the antibody response of rodent inbred strains to simple synthetic antigens. It became soon clear that among the genes involved (indicated as immune response (Ir) genes), those of the MHC complex played a major role. It was subsequently shown that, in the response to complex proteins, MHC genes in certain experimental models control high/low responder host phenotype and in other influence the repertoire of epitope specificity of antibody and T cell response (5–9, 10). MHC genes participate in the immune response at several level. A major function is “determinant selection”: MHC higly polymorphic proteins selectively bind peptides from processed antigens and present the selected peptides for recognition to the appropriate T cell receptor.
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Ruffilli, A., D’Amato, M., Menna, T., Maggi, E., Sacerdoti, G., Laho, C. (1996). Responsiveness to the Major Pollen Allergen of Parietaria Officinalis is Associated with Defined HLA-DRB1* Alleles in Italian and Spanish Allergic Patients. In: Sehon, A., HayGlass, K.T., Kraft, D. (eds) New Horizons in Allergy Immunotherapy. Advances in Experimental Medicine and Biology, vol 409. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5855-2_10
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DOI: https://doi.org/10.1007/978-1-4615-5855-2_10
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