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Blood Cell Biochemistry Volume 3 pp 99–114Cite as

Signaling Events in T-Lymphocyte-Dependent B-Lymphocyte Activation

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Part of the book series: Blood Cell Biochemistry ((BLBI,volume 3))

Abstract

The B-cell immune response is initiated in vivo by antigen binding to antigen-specific membrane immunoglobulin (mIg) molecules. Binding leads to antigen uptake, processing by proteases, and reexpression, now as immunogenic peptides in association with major histocompatibility complex, (MHC)-encoded class II (Ia) molecules (for a review, see Chesnut and Grey, 1986; Rock et al., 1984). Antigen binding to mIg also leads to signal transduction stimulating alterations in various cellular processes of the B cell (for a review, see Cambier and Ransom, 1987; DeFranco, 1987). Depending on its structure, binding of antigen to B-cell mlg may at one extreme provide a stimulus sufficient to induce expression of a large complex of genes that cause B-cell proliferation and differentiation into antibody-secreting plasma cells or, alternatively, it may stimulate expression of only a limited set of genes (Cambier and Ransom, 1987; DeFranco, 1987; Finkelman et al., 1986).

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Authors and Affiliations

  1. Department of Pediatrics, Divisions of Basic Sciences and Basic Immunology, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, 80206, USA

    John C. Cambier, Kathrin L. Lehmann & William F. Wade

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  1. John C. Cambier
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  2. Kathrin L. Lehmann
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  1. North East Thames Regional Transfusion Centre, Brentwood, Essex, England

    J. R. Harris

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Cambier, J.C., Lehmann, K.L., Wade, W.F. (1991). Signaling Events in T-Lymphocyte-Dependent B-Lymphocyte Activation. In: Harris, J.R. (eds) Blood Cell Biochemistry Volume 3. Blood Cell Biochemistry, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3796-0_4

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