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Microbial Infections pp 253–263Cite as

Stimulation of Host-Defense Mechanism with Synthetic Adjuvants and Recombinant Cytokines Against Viral Infection in Mice

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 319))

Abstract

The efficacy of synthetic immunoadjuvants and recombinant cytokines for the potentiation of host-resistance against virus infection was investigated using mouse models infected with Sendai virus and herpes simplex type 1 virus (HSV). The synthetic MDP derivative, MDP-Lys(L18), and recombinant cytokines, IL-1β, IFN-γ, G-CSF and GM-CSF were shown to be effective for the stimulation of nonspecific protection against Sendai virus infection in mice. Both MDP-Lys(L18) and GM-CSF were effective for the protection against HSV infection in cyclophosphamide (CY)-treated mice. B30-MDP was suggested to be useful as an immunoadjuvant for the potentiation of antigenicity of recombinant or component vaccines.

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Author information

Authors and Affiliations

  1. Institute of Immunological Science, Hokkaido University, Sapporo, Japan

    Ichiro Azuma, Chiaki Ishihara, Joji Iida, Yung Choon Yoo, Kumiko Yoshimatsu & Jiro Arikawa

  2. School of Veterinary Medicine, Rakuno-Gakuen University, Ebetsu, Japan

    Chiaki Ishihara

Authors
  1. Ichiro Azuma
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  2. Chiaki Ishihara
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  3. Joji Iida
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  4. Yung Choon Yoo
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  5. Kumiko Yoshimatsu
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  6. Jiro Arikawa
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Editor information

Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Herman Friedman  & Thomas W. Klein  & 

  2. Teikyo University School of Medicine, Tokyo, Japan

    Hideyo Yamaguchi

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© 1992 Springer Science+Business Media New York

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Azuma, I., Ishihara, C., Iida, J., Yoo, Y.C., Yoshimatsu, K., Arikawa, J. (1992). Stimulation of Host-Defense Mechanism with Synthetic Adjuvants and Recombinant Cytokines Against Viral Infection in Mice. In: Friedman, H., Klein, T.W., Yamaguchi, H. (eds) Microbial Infections. Advances in Experimental Medicine and Biology, vol 319. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3434-1_26

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  • DOI: https://doi.org/10.1007/978-1-4615-3434-1_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6519-8

  • Online ISBN: 978-1-4615-3434-1

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