Abstract
The growth of solid tumors requires a vascular supply, formed in the process of tumor-induced angiogenesis (TIA) (Folkman, 1990). TIA is an active sprouting of capillaries and new blood vessel formation due to some tumor cell-derived angiogenic factors capable of stimulating endothelial. cell proliferation and migration (Folkman and Klagsburn, 1987). TIA was shown to precede or accompany malignancy not only in various experimental. systems (Bouck, 1990) but also in natural. human tumors of the cervix, skin, breast and bladder (Folkman, 1990). The presence of newly formed blood vessels on the surface of the cervix can indicate an underlying but invisible tumor (Sillman, et al., 1981). Quantitation, either by routine histology or immunohistochemistry, of the number of blood vessels on tissue sections of breast carcinoma was shown to be useful for estimation of relapse-free survival. rate (Weidner et al., 1992) and probability of the metastatic disease (Horak et al., 1992).
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Majewski, S. et al. (1994). Retinoids and Ifnα Synergistically Decrease Tumor Cell-Induced Angiogenesis and Stimulate Lymphocyte Induced Angiogenesis. In: Stanley, M.A. (eds) Immunology of Human Papillomaviruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2449-6_48
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DOI: https://doi.org/10.1007/978-1-4615-2449-6_48
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