Abstract
Whether intrafusal and extrafusal fibres arise from a common progenitor in developing rat skeletal muscle is unresolved. Pedrosa & Thornell (1990) proposed that the primary myotubes which differentiate into the bag2 intrafusal fibre form from fusion of myogenic cells committed to differentiate into intrafusal fibres only. They further suggested that the precursors of bag2 fibres are capable of attracting sensory innervation to the developing muscle spindles, and that all subsequent generation types of intrafusal fibre form by a similar process (Pedrosa & Thornell, 1990). In contrast, Kucera & Walro (1990) proposed that both intrafusal and extrafusal fibres originate from several pools of bipotential myotubes, and that the interaction between primary afferents and bipotential myotubes mediates transformation of these myotubes into the different types of intrafusal fibres.
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© 1995 Springer Science+Business Media New York
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Walro, J.M., Wang, J. (1995). Origin of Spindles in Developing Rat Hindlimb Muscles. In: Taylor, A., Gladden, M.H., Durbaba, R. (eds) Alpha and Gamma Motor Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1935-5_40
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DOI: https://doi.org/10.1007/978-1-4615-1935-5_40
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