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GSH-Dependent Redox Regulation and Antioxidant Enzymes in the Formation of Resistance to Doxorubicin in K562 Human Erythroleukemia Cells

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Book cover Biological Reactive Intermediates VI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 500))

Abstract

Specific changes of antioxidant enzymes during initiation and promotion stages are special value for the study of role and regulation of free radical processes in mechanisms of cancinogenesis for prevention and reversion of malignization. In addition, among factors controlling the balance of homeostasis and formation of cellular resistance to environment free radical processes play the important role due to the including into proliferation and apoptosis which is discussed currently as one of the key events in free radical concept of chemical carcinogenesis (1).

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References

  1. E.Kalinina, A.N.Saprin. Oxidative stress and its role in the mechanisms of apoptosis and development of pathological processes. Adv.biol.chem. 39:289 (1999).

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  2. E.Kalinina, M.Novichkova, N.P.Scherbak, A.Saprin. Progesterone inhibition of glutathione S-transferase P1–1 and its antiproliferative effect on human erythroleukemia K562 line cells. Prob.oncol. 46(1):68 (2000).

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Author information

Authors and Affiliations

  1. Lab.Biochemistry & Biophysics of Cancer, Institute of Chemical Physics, Russia

    Elena Kalinina, Maria Novichkova, Viktoria Solomka & Anatoly N. Saprin

  2. Institute of Carcinogenesis, Kosygin Str.4, Moscow, 117977, Russia

    Nikolayi P. Scherbak

Authors
  1. Elena Kalinina
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  2. Maria Novichkova
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  3. Viktoria Solomka
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  4. Anatoly N. Saprin
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  5. Nikolayi P. Scherbak
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Editor information

Editors and Affiliations

  1. Université René Descartes, Paris, France

    Patrick M. Dansette

  2. Rutgers University and The Environmental & Occupational Health Sciences Institute, Piscataway, New Jersey, USA

    Robert Snyder

  3. CNRS, Paris, France

    Marcel Delaforge

  4. University of Surrey, Guildford, Surrey, England

    G. Gordon Gibson

  5. Institute of Toxicology and Environmental Health, The Technical University of Munich, Munich, Germany

    Helmut Greim

  6. Medical University of South Carolina, Charleston, South Carolina, USA

    David J. Jollow

  7. University of Texas, Austin, Texas, USA

    Terrence J. Monks

  8. University of Arizona, Tucson, Arizona, USA

    I. Glenn Sipes

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© 2001 Springer Science+Business Media New York

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Kalinina, E., Novichkova, M., Solomka, V., Saprin, A.N., Scherbak, N.P. (2001). GSH-Dependent Redox Regulation and Antioxidant Enzymes in the Formation of Resistance to Doxorubicin in K562 Human Erythroleukemia Cells. In: Dansette, P.M., et al. Biological Reactive Intermediates VI. Advances in Experimental Medicine and Biology, vol 500. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0667-6_36

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  • DOI: https://doi.org/10.1007/978-1-4615-0667-6_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5185-6

  • Online ISBN: 978-1-4615-0667-6

  • eBook Packages: Springer Book Archive

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