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Alkalinizing Agents for the Treatment of Cardiac Arrest

  • Chapter
Hypoxia, Metabolic Acidosis, and the Circulation

Part of the book series: Clinical Physiology Series ((CLINPHY))

Abstract

Sodium bicarbonate has been administered during cardiopulmonary resuscitation (CPR) on the assumption that reversal of metabolic (lactic) acidosis would favor cardiac resuscitation. The history of its use is sumarized in Table 9–1. The pioneers of modern-day cardiopulmonary resuscitation, Kouwenhoven et al. (60), proposed that blood pH best be maintained within the normal range. This was intended to improve “cardiac action” and to increase “responsiveness to vasopressor agents” (52). They therefore recommended that sodium bicarbonate be routinely administered to adult patients in amounts of 44 mEq (3.75 g) at intervals of 5–10 min during cardiac resuscitation. The use of sodium bicarbonate was further supported by clinical reports documenting severe metabolic acidosis during CPR in patients whose cardiac function was restored when sodium bicarbonate was administered (28,45,97,98).

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Authors
  1. Max Harry Weil
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  2. Fulvio Kette
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  3. Raul J. Gazmuri
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  4. Eric C. Rackow
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Editors and Affiliations

  1. Department of Medicine, School of Medicine and Veterans Affairs Medical Center, University of California, San Francisco, California, USA

    Allen I. Arieff M.D.

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© 1992 American Physiological Society

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Weil, M.H., Kette, F., Gazmuri, R.J., Rackow, E.C. (1992). Alkalinizing Agents for the Treatment of Cardiac Arrest. In: Arieff, A.I. (eds) Hypoxia, Metabolic Acidosis, and the Circulation. Clinical Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7542-2_9

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  • DOI: https://doi.org/10.1007/978-1-4614-7542-2_9

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7542-2

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