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Melanoma Immunology and Immunotherapy

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Abstract

Immunotherapy has been a mainstay for decades, however in recent years a number of new approaches to harness the immune system have been developed and revolutionized the treatment of this disease. This chapter serves as an introduction to immunotherapy efforts in melanoma that includes a description of the immune system elements and tumor immune microenvironment and the justification for their targeting, presentation of proof of concept examples of effective immunotherapy, and a discussion of some of the present dilemmas in the field that need to be sorted out over the coming decade.

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Author information

Authors and Affiliations

  1. Center for Melanoma, MGH Cancer Center, Boston, MA, USA

    Ryan J. Sullivan

  2. Dana Farber Cancer Institute, Boston, MA, USA

    F. Stephen Hodi

  3. Department of Medicine, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Boston, MA, USA

    F. Stephen Hodi

Authors
  1. Ryan J. Sullivan
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  2. F. Stephen Hodi
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Corresponding author

Correspondence to Ryan J. Sullivan .

Editor information

Editors and Affiliations

  1. Harvard/MGH Cutaneous Biology Research C Massachusetts General Hospital, Boston, MA, USA

    David E. Fisher

  2. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Boris C. Bastian

Section Editor information

  1. Department of Dermatology, Harvard/MGH Cutaneous Biology Research Center, and Melanoma Program, MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    David E. Fisher

  2. QIMR Berghofer Medical Research Institute, Herston, QLD, Australia

    Nick Hayward

  3. QIMR Berghofer Medical Research Institute, Herston, QLD, Australia

    David C. Whiteman

  4. Henri and Belinda Termeer Center for Targeted Therapies, MGH Cancer Center, Cambridge, MA, USA

    Keith T. Flaherty

  5. Framingham, MA, USA

    F. Stephen Hodi

  6. Department of Medicine, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA, USA

    F. Stephen Hodi

  7. Auburndale, MA, USA

    Hensin Tsao

  8. Harvard-MIT Health Sciences and Technology, Cambridge, MA, USA

    Hensin Tsao

  9. Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA

    Glenn Merlino Ph.D.

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Sullivan, R.J., Hodi, F.S. (2019). Melanoma Immunology and Immunotherapy. In: Fisher, D., Bastian, B. (eds) Melanoma. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7322-0_36-2

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  • DOI: https://doi.org/10.1007/978-1-4614-7322-0_36-2

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Chapter history

  1. Latest

    Melanoma Immunology and Immunotherapy
    Published:
    05 June 2019

    DOI: https://doi.org/10.1007/978-1-4614-7322-0_36-2

  2. Original

    Introduction to Melanoma Immunology
    Published:
    25 February 2019

    DOI: https://doi.org/10.1007/978-1-4614-7322-0_36-1

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