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Immune Responses to Stress

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Encyclopedia of Behavioral Medicine

Synonyms

Stress response

Definition

Stress can be thought of as a constellation of events comprised of a stimulus, “stressor,” that precipitates a reaction in the brain, “stress perception,” that activates fight-or-flight mechanisms, “stress response” (Dhabhar and McEwen 1997). This entry will concentrate on what happens in the immune system in response to stress.

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Introduction

In 1884, the editor of the British Medical Journal noted that at funerals, “the depression of spirits under which the chief mourners labour at these melancholy occasions peculiarly predisposes them to some of the worst effects of the chill.” Despite many such anecdotes suggesting a link between psychological factors and immune function, it is only relatively recently that these associations have received widespread acceptance in the scientific and medical communities. In fact, as recently as 1984, an editorial piece in Natureproclaimed the persistence of a “stout band of near skeptics” who, while...

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References and Further Reading

  • Ader, R. (2000). On the development of psychoneuroimmunology. European Journal of Pharmacology, 405, 167–176.

    Article  CAS  Google Scholar 

  • Antoni, M. H. (2003). Stress management and psychoneuroimmunology in HIV infection. CNS Spectrums, 8, 40–51.

    Article  Google Scholar 

  • Armaiz-Pena, G. N., Lutgendorf, S. K., Cole, S. W., & Sood, A. K. (2009). Neuroendocrine modulation of cancer progression. Brain, Behavior, and Immunity, 23, 10–15.

    Article  CAS  Google Scholar 

  • Burns, V. E., & Gallagher, S. (2010). Antibody response to vaccination as a marker of in vivo immune function in psychophysiological research. Neuroscience and Biobehavioral Reviews, 35, 122–126.

    Article  CAS  Google Scholar 

  • Chen, E., & Miller, G. E. (2007). Stress and inflammation in exacerbations of asthma. Brain, Behavior, and Immunity, 21, 993–999.

    Article  CAS  Google Scholar 

  • Cohen, S. (2005). Keynote presentation at the eight international congress of behavioral medicine: The Pittsburgh common cold studies: Psychosocial predictors of susceptibility to respiratory infectious illness. International Journal of Behavioral Medicine, 12, 123–131.

    Article  Google Scholar 

  • Cohen, S., Miller, G. E., & Rabin, B. S. (2001). Psychological stress and antibody response to immunization: A critical review of the human literature. Psychosomatic Medicine, 63, 7–18.

    Article  CAS  Google Scholar 

  • Cole, S. W. (2008). Psychosocial influences on HIV-1 disease progression: Neural, endocrine, and virologic mechanisms. Psychosomatic Medicine, 70, 562–568.

    Article  Google Scholar 

  • Dhabhar, F. S. (2002). Stress-induced augmentation of immune function – The role of stress hormones, leukocyte trafficking, and cytokines. Brain, Behavior, and Immunity, 16, 785–798.

    Article  CAS  Google Scholar 

  • Dhabhar, F. S., & McEwen, B. S. (1997). Acute stress enhances while chronic stress suppresses cell-mediated immunity in vivo: A potential role for leukocyte trafficking. Brain, Behavior, and Immunity, 11, 286–306.

    Article  CAS  Google Scholar 

  • Edwards, K. M., Burns, V. E., Carroll, D., Drayson, M., & Ring, C. (2007). The acute stress-induced immunoenhancement hypothesis. Exercise and Sport Sciences Reviews, 35, 150–155.

    Article  Google Scholar 

  • Fleshner, M., & Laudenslager, M. L. (2004). Psychoneuroimmunology: Then and now. Behavioral and Cognitive Neuroscience Reviews, 3, 114–130.

    Article  Google Scholar 

  • Glaser, R., & Kiecolt-Glaser, J. K. (2005). Stress-induced immune dysfunction: Implications for health. Nature Reviews Immunology, 5, 243–251.

    Article  CAS  Google Scholar 

  • Kelley, K. W., Bluthe, R. M., Dantzer, R., Zhou, J. H., Shen, W. H., Johnson, R. W., et al. (2003). Cytokine-induced sickness behavior. Brain, Behavior, and Immunity, 17(Suppl 1), S112–S118.

    Article  CAS  Google Scholar 

  • Kemeny, M. E. (2009). Psychobiological responses to social threat: Evolution of a psychological model in psychoneuroimmunology. Brain, Behavior, and Immunity, 23, 1–9.

    Article  Google Scholar 

  • Lazarus, R. S., & Folkman, S. (1984). Stress, appraisal, and coping. New York: Springer.

    Google Scholar 

  • Maddox, J. (1984). Psychoimmunology before its time. Nature, 309, 400.

    Article  CAS  Google Scholar 

  • Segerstrom, S. C. (2010). Resources, stress, and immunity: An ecological perspective on human psychoneuroimmunology. Annals of Behavioral Medicine, 40, 114–125.

    Article  Google Scholar 

  • Segerstrom, S. C., & Miller, G. E. (2004). Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry. Psychological Bulletin, 130, 601–630.

    Article  Google Scholar 

  • Walburn, J., Vedhara, K., Hankins, M., Rixon, L., & Weinman, J. (2009). Psychological stress and wound healing in humans: A systematic review and meta-analysis. Journal of Psychosomatic Research, 67, 253–271.

    Article  Google Scholar 

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Correspondence to Jos A. Bosch .

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Rector, J., Burns, V.E., Bosch, J.A., Anane, L. (2019). Immune Responses to Stress. In: Gellman, M. (eds) Encyclopedia of Behavioral Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6439-6_464-2

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  • DOI: https://doi.org/10.1007/978-1-4614-6439-6_464-2

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