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Evaluation of the Taurine Concentrations in Dog Plasma and Aqueous Humour: A Pilot Study

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Taurine 8

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 775))

Abstract

In the 70s, the amino acid taurine was found essential for photoreceptor survival. Recently, we found that taurine depletion can also trigger retinal ganglion cell degeneration both in vitro and in vivo. Therefore, evaluation of taurine levels could be a crucial biomarker for different pathologies of retinal ganglion cells such as glaucoma. Because different breeds of dog can develop glaucoma, we performed taurine measurements on plasma and aqueous humour samples from pet dogs. Here, we exposed results from a pilot study on normal selected breed of pet dogs, without any ocular pathology. Samples were collected by veterinarians who belong to the Réseau Européen d’Ophtalmologie Vétérinaire et de Vision Animale. Following measurements by high-performance liquid chromatography (HPLC), the averaged taurine concentration was 162.3 μM in the plasma and 51.8 μM in the aqueous humour. No correlation was observed between these two taurine concentrations, which exhibited a ratio close to 3. Further studies will determine if these taurine concentrations are changed in glaucomatous dogs.

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Abbreviations

RGC:

Retinal ganglion cells

HPLC:

High-performance liquid chromatography

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Acknowledgments

Authors acknowledge Dr. Azoulay, T.; Dr. Boderiou, Y.; Boillot, T.; Cantaloube, B.; Durieux, P.; Goulle, F.; Isard, P-F.; Maller, D.; Michaud, Y.; Philippe, R.; and Rosolen, SG. from the REOVVA group (www.reovva.com) for their contribution to this work. This work was supported by INSERM, Université Pierre et Marie Curie (Paris VI), Fondation Ophtalmologique A. de Rothschild (Paris), Fédération de la Recherche Médicale and Fondation Bailly, the city of Paris and the Regional Council of Ile-de-France.

Author information

Authors and Affiliations

  1. Réseau Européen d’Ophtalmologie Vétérinaire et de Vision Animale (REOVVA), Asnières, France

    Serge-George Rosolen

  2. Clinique Vétérinaire Voltaire, Asnières, France

    Serge-George Rosolen

  3. INSERM, U968, Institut de la Vision, Paris, France

    Serge-George Rosolen, José-Alain Sahel, Serge Picaud & Nicolas Froger

  4. UPMC Université Paris 06, UMR_S 968, Institut de la Vision, Paris, France

    Serge-George Rosolen, José-Alain Sahel, Serge Picaud & Nicolas Froger

  5. CNRS, UMR 7210, Institut de la Vision, Paris, France

    Serge-George Rosolen, José-Alain Sahel, Serge Picaud & Nicolas Froger

  6. Stress cellulaire: Physiopathologie, stratégies nutritionnelles et thérapeutiques innovantes, EA 4466, Faculté de Pharmacie, Université Descartes Paris V, Paris, France

    Nathalie Neveux

  7. Service Inter-hospitalier de biochimie, CHU Cochin-St-Vincent de Paul, AP-HP, Paris, France

    Nathalie Neveux

  8. Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, Paris, France

    José-Alain Sahel, Serge Picaud & Nicolas Froger

  9. Institute of Ophthalmology, University College of London, London, UK

    José-Alain Sahel

  10. Fondation Ophtalmologique Adolphe de Rothschild, Paris, France

    José-Alain Sahel & Serge Picaud

  11. French Academy of Sciences, Paris, France

    José-Alain Sahel

Authors
  1. Serge-George Rosolen
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  2. Nathalie Neveux
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  3. José-Alain Sahel
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  4. Serge Picaud
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  5. Nicolas Froger
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Corresponding author

Correspondence to Serge-George Rosolen .

Editor information

Editors and Affiliations

  1. City University of New York, Center for Developmental Neuroscience, College of Staten Island, 2800 Victory Blvd, Staten Island, 10314, New York, USA

    Abdeslem El Idrissi

  2. City University of New York, Department of Biology, College of Staten Island, Victory Blvd 2800, Staten Island, 10314, New York, USA

    William J. L'Amoreaux

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Rosolen, SG., Neveux, N., Sahel, JA., Picaud, S., Froger, N. (2013). Evaluation of the Taurine Concentrations in Dog Plasma and Aqueous Humour: A Pilot Study. In: El Idrissi, A., L'Amoreaux, W. (eds) Taurine 8. Advances in Experimental Medicine and Biology, vol 775. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6130-2_12

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