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Autophagic Pathways and Parkinson Disease

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Handbook of Neurotoxicity

Abstract

Autophagy is responsible for the degradation and recycling of intracellular material including organelles, cytosolic proteins, and accumulated misfolded proteins. Increasing evidence implicates autophagy dysfunction in several neurodegenerative disorders including Parkinson’s disease (PD). In this chapter, we analyze recent studies that provide new links between genes associated to PD and the autophagy process. Mutations in PD-associated proteins like α-synuclein, parkin, PINK1, LRRK2, DJ-1, UCH-L1, ATP12A3, and GBA have been recently directly or indirectly linked to alterations in the autophagic system, thereby contributing to the understanding of the role of this system in the pathogenesis of Parkinson’s disease.

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Abbreviations

AD:

Alzheimer’s disease

ALS:

Amyotrophic lateral sclerosis

CMA:

Chaperone-mediated autophagy

GBase:

Glucocerebrosidase protein

GD:

Gaucher’s disease

HD:

Huntington’s disease

LB:

Lewy bodies

LIR:

LC3-interacting region

LMP:

Lysosomal membrane permeabilization

LSD:

Lysosomal storage disorders

MPTP:

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

MTOC:

Microtubule-organizing center

PD:

Parkinson’s disease

ROS:

Reactive oxygen species

SNpc:

Substantia nigra pars compacta

UBA domain:

Ubiquitin-associated domain

UPS:

Ubiquitin-proteasome system

WT:

Wild type

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Authors and Affiliations

  1. Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute–CIBERNED, Pg. Vall d’Hebron 119-129, Barcelona, 08035, Spain

    Miquel Vila & Marta Martínez-Vicente

  2. Department of Biochemistry and Molecular Biology, Autonomous University of Barcelona (UAB), Barcelona, Spain

    Miquel Vila & Marta Martínez-Vicente

  3. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain

    Miquel Vila

Authors
  1. Miquel Vila
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  2. Marta Martínez-Vicente
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Correspondence to Marta Martínez-Vicente .

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Editors and Affiliations

  1. Department of Biomedical Sciences, East Tennessee State University, Johnson City, Tennessee, USA

    Richard M. Kostrzewa

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Vila, M., Martínez-Vicente, M. (2014). Autophagic Pathways and Parkinson Disease. In: Kostrzewa, R. (eds) Handbook of Neurotoxicity. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5836-4_15

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